DegronMD

Uniprot ID: O43491

Source protein: Band 4.1-like protein 2

Source gene: EPB41L2

Class: DEG_SCF_TRCP1_1

Location: 918:924

E3 ligase: BTRC

DEGRON score: 0.9925

ASA_SCORE: 78.7714

COIL: 0.7344

CONS_SCORE: 0.5416

DSS_SCORE: 0.5295

HELIX: 0.0661

FCONS_SCORE: 1.0712

RIG_SCORE: 0.7269

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G916V	TCGA-05-4424	LUAD	TCGA	DSGTLLT	DEG_SCF_TRCP1_1	0.2778
p.G916C	TCGA-05-4424	LUAD	TCGA	DSGTLLT	DEG_SCF_TRCP1_1	0.2778
p.S932F	TCGA-FW-A3R5	SKCM	TCGA	DSGTLLT	DEG_SCF_TRCP1_1	0.1111
p.S932F	TCGA-GN-A4U3	SKCM	TCGA	DSGTLLT	DEG_SCF_TRCP1_1	0.1111
p.S908C	TCGA-GM-A2D9	BRCA	TCGA	DSGTLLT	DEG_SCF_TRCP1_1	0.5
p.T921M	SIDM00845	Burkitt's Lymphoma	GDSC	DSGTLLT	DEG_SCF_TRCP1_1	0.6312
p.T921M	SIDM00032	Bladder Carcinoma	GDSC	DSGTLLT	DEG_SCF_TRCP1_1	0.6312
p.T921M	SIDM01519	Head and Neck Carcinoma	GDSC	DSGTLLT	DEG_SCF_TRCP1_1	0.6312
p.T921A	SIDM00845	Burkitt's Lymphoma	GDSC	DSGTLLT	DEG_SCF_TRCP1_1	0.6028
p.E931D	ACH-002205	Skin Cancer	CCLE	DSGTLLT	DEG_SCF_TRCP1_1	0.1389
p.E931D	WM1552C	skin	COSMIC	DSGTLLT	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43491	Band 4.1-like protein 2	DEG_SCF_TRCP1_1	918:924	DSGTLLT	BTRC	0.9925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons