DegronMD

Uniprot ID: O43491

Source protein: Band 4.1-like protein 2

Source gene: EPB41L2

Class: DEG_COP1_1

Location: 789:797

E3 ligase: COP1

DEGRON score: 0.8043

ASA_SCORE: 99.7778

COIL: 0.6838

CONS_SCORE: 0.4021

DSS_SCORE: 0.5575

HELIX: 0.145

FCONS_SCORE: 0.946

RIG_SCORE: 0.73

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S798I	TCGA-VS-A9V1	CESC	TCGA	EREEAVPEA	DEG_COP1_1	0.75
p.E796K	SIDM01766	Chondrosarcoma	GDSC	EREEAVPEA	DEG_COP1_1	0.7022
p.K786Q	TCGA-B5-A3FA	UCEC	TCGA	EREEAVPEA	DEG_COP1_1	0.3611
p.P800L	23132-87	stomach	COSMIC	EREEAVPEA	DEG_COP1_1	0.25
p.T785N	NCI-H2087	lung	COSMIC	EREEAVPEA	DEG_COP1_1	0.2222
p.S784T	MLMA	haematopoietic_and_lymphoid_tissue	COSMIC	EREEAVPEA	DEG_COP1_1	0.1944
p.P783L	TCGA-EE-A2GI	SKCM	TCGA	EREEAVPEA	DEG_COP1_1	0.1667
p.G804V	TCGA-MN-A4N4	LUAD	TCGA	EREEAVPEA	DEG_COP1_1	0.1389
p.E782K	ACH-002253	Lymphoma	CCLE	EREEAVPEA	DEG_COP1_1	0.1389
p.E782K	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	EREEAVPEA	DEG_COP1_1	0.1389
p.R804H	NCI-H1048	lung	COSMIC	EREEAVPEA	DEG_COP1_1	0.1389
p.P781L	TCGA-DA-A1IA	SKCM	TCGA	EREEAVPEA	DEG_COP1_1	0.1111
p.G781E	ACH-000426	Myeloma	CCLE	EREEAVPEA	DEG_COP1_1	0.1111
p.E806Q	ACH-001411	Bladder Cancer	CCLE	EREEAVPEA	DEG_COP1_1	0.0833
p.E779V	TCGA-58-A46J	LUSC	TCGA	EREEAVPEA	DEG_COP1_1	0.0556
p.E807D	WM1552C	skin	COSMIC	EREEAVPEA	DEG_COP1_1	0.0556

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43491	Band 4.1-like protein 2	DEG_COP1_1	789:797	EREEAVPEA	COP1	0.8043	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons