DegronMD

Uniprot ID: O43491

Source protein: Band 4.1-like protein 2

Source gene: EPB41L2

Class: LIG_APCC_ABBA_1

Location: 991:996

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.988

ASA_SCORE: 75.7167

COIL: 0.1392

CONS_SCORE: 0.5629

DSS_SCORE: 0.5797

HELIX: 0.0085

FCONS_SCORE: 1.2586

RIG_SCORE: 0.7852

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E996Q	TCGA-EA-A3HU	CESC	TCGA	VVVHKE	LIG_APCC_ABBA_1	0.6744
p.E996Q	DO6320	CESC	ICGC	VVVHKE	LIG_APCC_ABBA_1	0.6744
p.H994R	TCGA-G3-A5SK	LIHC	TCGA	VVVHKE	LIG_APCC_ABBA_1	0.8244
p.H994R	DO45005	LIHC	ICGC	VVVHKE	LIG_APCC_ABBA_1	0.8244
p.E1002Q	TCGA-N9-A4Q7	UCS	TCGA	VVVHKE	LIG_APCC_ABBA_1	0.1667
p.E996A	DO222500	ESCA	ICGC	VVVHKE	LIG_APCC_ABBA_1	0.7701
p.S987L	DO228946	LICA	ICGC	VVVHKE	LIG_APCC_ABBA_1	0.6667
p.H983N	DO229038	LICA	ICGC	VVVHKE	LIG_APCC_ABBA_1	0.1111
p.E998Q	DO230993	LUSC	ICGC	VVVHKE	LIG_APCC_ABBA_1	0.2778
p.E998Q	DO230990	LUSC	ICGC	VVVHKE	LIG_APCC_ABBA_1	0.2778
p.E981G	DO230451	UTCA	ICGC	VVVHKE	LIG_APCC_ABBA_1	0.0556
p.E1001D	SIDM00976	Melanoma	GDSC	VVVHKE	LIG_APCC_ABBA_1	0.1944
p.E1001D	WM1552C	skin	COSMIC	VVVHKE	LIG_APCC_ABBA_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons