DegronMD

Uniprot ID: Q9Y2J2

Source protein: Band 4.1-like protein 3

Source gene: EPB41L3

Class: LIG_APCC_ABBA_1

Location: 1072:1077

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.986

ASA_SCORE: 70.7

COIL: 0.1738

CONS_SCORE: 0.6405

DSS_SCORE: 0.6081

HELIX: 0.007

FCONS_SCORE: 1.2952

RIG_SCORE: 0.7688

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1068T	TCGA-69-7980	LUAD	TCGA	VVVHKE	LIG_APCC_ABBA_1	0.6667
p.M1067I	TCGA-85-8580	LUSC	TCGA	VVVHKE	LIG_APCC_ABBA_1	0.1944
p.Q1063P	TCGA-B5-A5OC	UCEC	TCGA	VVVHKE	LIG_APCC_ABBA_1	0.0833
p.E1079D	TCGA-BA-A4II	HNSC	TCGA	VVVHKE	LIG_APCC_ABBA_1	0.2778
p.E1079D	TCGA-BR-8368	STAD	TCGA	VVVHKE	LIG_APCC_ABBA_1	0.2778
p.S1068L	TCGA-GC-A3I6	BLCA	TCGA	VVVHKE	LIG_APCC_ABBA_1	0.6667
p.H1064N	TCGA-NC-A5HR	LUSC	TCGA	VVVHKE	LIG_APCC_ABBA_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons