DegronMD - Q9Y2J2(EPB41L3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L539R	TCGA-06-5416	GBM	TCGA	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.25
p.L539R	DO10880	GBM	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.25
p.P100S	TCGA-21-5783	LUSC	TCGA	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation altering degron motif	0.5641
p.P100S	DO27437	LUSC	ICGC	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation altering degron motif	0.5641
p.S1068T	TCGA-69-7980	LUAD	TCGA	VVVHKE	LIG_APCC_ABBA_1	1072:1077	Mutation blocking phosphorylation signal	0.6667
p.S1068T	TCGA-69-7980	LUAD	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	1071:1077	Mutation blocking phosphorylation signal	0.6944
p.M1067I	TCGA-85-8580	LUSC	TCGA	VVVHKE	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.1944
p.M1067I	TCGA-85-8580	LUSC	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	1071:1077	Mutation rewiring degron network	0.2222
p.K1061T	TCGA-A4-7997	KIRP	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	1071:1077	Mutation blocking ubiquitination signal	0.5
p.T526I	TCGA-A5-A0G1	UCEC	TCGA	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1667
p.T526I	DO42472	UCEC	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1667
p.R529H	TCGA-AX-A2HC	UCEC	TCGA	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.25
p.R529H	DO41572	UCEC	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.25
p.K1071N	TCGA-AZ-6598	COAD	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	1071:1077	Mutation altering degron motif	0.6918
p.K1071N	TCGA-BR-8363	STAD	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	1071:1077	Mutation altering degron motif	0.6918
p.K1071N	TCGA-R5-A7ZE	STAD	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	1071:1077	Mutation altering degron motif	0.6918
p.K1071N	TCGA-VQ-A8PJ	STAD	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	1071:1077	Mutation altering degron motif	0.6918
p.K1071N	TCGA-VQ-A91V	STAD	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	1071:1077	Mutation altering degron motif	0.6918
p.Q1063P	TCGA-B5-A5OC	UCEC	TCGA	VVVHKE	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.0833
p.Q1063P	TCGA-B5-A5OC	UCEC	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	1071:1077	Mutation rewiring degron network	0.1111
p.E1079D	TCGA-BA-A4II	HNSC	TCGA	VVVHKE	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.2778
p.E1079D	TCGA-BA-A4II	HNSC	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	1071:1077	Mutation rewiring degron network	0.2778
p.E1079D	TCGA-BR-8368	STAD	TCGA	VVVHKE	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.2778
p.E1079D	TCGA-BR-8368	STAD	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	1071:1077	Mutation rewiring degron network	0.2778
p.S524T	TCGA-CK-4951	COAD	TCGA	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1111
p.S524T	DO10582	COAD	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1111
p.K90N	TCGA-CN-4730	HNSC	TCGA	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation substituting flanking lysine	0.25
p.K90N	DO14234	HNSC	ICGC	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation substituting flanking lysine	0.25
p.K533E	TCGA-D7-A4YY	STAD	TCGA	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation altering degron motif	0.7022
p.K533E	DO47733	STAD	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation altering degron motif	0.7022
p.I103V	TCGA-F5-6814	READ	TCGA	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation altering degron motif	0.5965
p.I103V	DO36556	READ	ICGC	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation altering degron motif	0.5965
p.K102M	TCGA-G4-6299	COAD	TCGA	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation altering degron motif	0.6951
p.K102M	DO7874	COAD	ICGC	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation altering degron motif	0.6951
p.S1068L	TCGA-GC-A3I6	BLCA	TCGA	VVVHKE	LIG_APCC_ABBA_1	1072:1077	Mutation blocking phosphorylation signal	0.6667
p.S1068L	TCGA-GC-A3I6	BLCA	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	1071:1077	Mutation blocking phosphorylation signal	0.6944
p.C537F	TCGA-HU-A4G3	STAD	TCGA	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.3056
p.C537F	DO47807	STAD	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.3056
p.K1061R	TCGA-IN-A6RJ	STAD	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	1071:1077	Mutation blocking ubiquitination signal	0.5
p.R529C	TCGA-IN-A6RP	STAD	TCGA	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.25
p.R529C	DO51741	STAD	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.25
p.P540T	TCGA-J4-8198	PRAD	TCGA	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.2222
p.P540T	DO36303	PRAD	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.2222
p.H1064N	TCGA-NC-A5HR	LUSC	TCGA	VVVHKE	LIG_APCC_ABBA_1	1072:1077	Mutation rewiring degron network	0.1111
p.H1064N	TCGA-NC-A5HR	LUSC	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	1071:1077	Mutation rewiring degron network	0.1389
p.T534A	DO222439	BTCA	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation altering degron motif	0.7139
p.A536T	DO8103	COAD	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation altering degron motif	0.7139
p.A536T	DO230312	COCA	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation altering degron motif	0.7139
p.G541D	DO234401	ESAD	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1944
p.L87I	DO233181	GACA	ICGC	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation rewiring degron network	0.0556
p.T526M	DO16276	KIRC	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1667
p.G532R	DO50206	LGG	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation altering degron motif	0.7568
p.D522E	DO229038	LICA	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.0556
p.E527D	DO50958	LICA	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1944
p.T526K	DO52256	LIHC	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1667
p.S93R	DO231645	LINC	ICGC	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation blocking phosphorylation signal	0.6667
p.E538Q	DO23666	LUAD	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.2778
p.D540E	DO231149	LUSC	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.2222
p.A545E	DO219193	LUSC	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.0833
p.S539L	DO232863	NACA	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.25
p.D531E	DO48973	PBCA	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.3056
p.R525C	DO219253	PRAD	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1389
p.R525C	DO38715	STAD	ICGC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1389
p.R525C	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1389
p.P544L	SIDM02049	Pancreatic Carcinoma	GDSC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1111
p.P544L	SIDM00545	Melanoma	GDSC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1111
p.S97P	SIDM02070	Esophageal Carcinoma	GDSC	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation altering degron motif	0.6752
p.L96I	SIDM01043	Other Sarcomas	GDSC	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation rewiring degron network	0.3056
p.L96I	ACH-000913	Endometrial/Uterine Cancer	CCLE	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation rewiring degron network	0.3056
p.L96I	ESS-1	endometrium	COSMIC	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation rewiring degron network	0.3056
p.N535S	SIDM00596	Endometrial Carcinoma	GDSC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation altering degron motif	0.7069
p.N535S	ACH-001517	Endometrial/Uterine Cancer	CCLE	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation altering degron motif	0.7069
p.N535S	HEC-1	endometrium	COSMIC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation altering degron motif	0.7069
p.S94R	SIDM00872	Breast Carcinoma	GDSC	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation blocking phosphorylation signal	0.6944
p.S94R	ACH-000859	Breast Cancer	CCLE	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation blocking phosphorylation signal	0.6944
p.S94R	HCC1954	breast	COSMIC	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation blocking phosphorylation signal	0.6944
p.S93N	SIDM00217	Colorectal Carcinoma	GDSC	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation blocking phosphorylation signal	0.6667
p.S93N	ACH-000999	Colon/Colorectal Cancer	CCLE	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation blocking phosphorylation signal	0.6667
p.S93N	SNU-1040	large intestine	COSMIC	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation blocking phosphorylation signal	0.6667
p.P525H	SIDM01617	Endometrial Carcinoma	GDSC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1389
p.P525H	ACH-000994	Endometrial/Uterine Cancer	CCLE	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1389
p.C532Y	SIDM01749	Osteosarcoma	GDSC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation altering degron motif	0.5976
p.C532Y	ACH-000340	Non-Cancerous	CCLE	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation altering degron motif	0.5976
p.R525H	KMH-2	thyroid	COSMIC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1389
p.Y541F	L-1236	haematopoietic and lymphoid tissue	COSMIC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1944
p.A535V	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation altering degron motif	0.6936
p.A529T	SK-N-AS	autonomic ganglia	COSMIC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.25
p.S546R	SK-MES-1	lung	COSMIC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.0556
p.V532M	SU-DHL-6	haematopoietic and lymphoid tissue	COSMIC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation altering degron motif	0.7208
p.A543T	COLO-783	skin	COSMIC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation rewiring degron network	0.1389
p.A535T	SNG-M	endometrium	COSMIC	CKEND	DEG_APCC_KENBOX_2	532:536	Mutation altering degron motif	0.7139
p.D102N	RC-K8	haematopoietic and lymphoid tissue	COSMIC	SRSPLKIVK	DEG_APCC_DBOX_1	97:105	Mutation altering degron motif	0.6932

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPB41L3

UniProt ID: Q9Y2J2

Entrez ID: 23136

Protein name: Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPB41L3 in