DegronMD

Uniprot ID: Q9Y2J2

Source protein: Band 4.1-like protein 3

Source gene: EPB41L3

Class: DEG_APCC_DBOX_1

Location: 97:105

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9891

ASA_SCORE: 105.5222

COIL: 0.9007

CONS_SCORE: 0.1644

DSS_SCORE: 0.4866

HELIX: 0.036

FCONS_SCORE: 0.5424

RIG_SCORE: 0.7118

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P100S	TCGA-21-5783	LUSC	TCGA	SRSPLKIVK	DEG_APCC_DBOX_1	0.5641
p.P100S	DO27437	LUSC	ICGC	SRSPLKIVK	DEG_APCC_DBOX_1	0.5641
p.K90N	TCGA-CN-4730	HNSC	TCGA	SRSPLKIVK	DEG_APCC_DBOX_1	0.25
p.K90N	DO14234	HNSC	ICGC	SRSPLKIVK	DEG_APCC_DBOX_1	0.25
p.I103V	TCGA-F5-6814	READ	TCGA	SRSPLKIVK	DEG_APCC_DBOX_1	0.5965
p.I103V	DO36556	READ	ICGC	SRSPLKIVK	DEG_APCC_DBOX_1	0.5965
p.K102M	TCGA-G4-6299	COAD	TCGA	SRSPLKIVK	DEG_APCC_DBOX_1	0.6951
p.K102M	DO7874	COAD	ICGC	SRSPLKIVK	DEG_APCC_DBOX_1	0.6951
p.L87I	DO233181	GACA	ICGC	SRSPLKIVK	DEG_APCC_DBOX_1	0.0556
p.S93R	DO231645	LINC	ICGC	SRSPLKIVK	DEG_APCC_DBOX_1	0.6667
p.S97P	SIDM02070	Esophageal Carcinoma	GDSC	SRSPLKIVK	DEG_APCC_DBOX_1	0.6752
p.L96I	SIDM01043	Other Sarcomas	GDSC	SRSPLKIVK	DEG_APCC_DBOX_1	0.3056
p.L96I	ACH-000913	Endometrial/Uterine Cancer	CCLE	SRSPLKIVK	DEG_APCC_DBOX_1	0.3056
p.L96I	ESS-1	endometrium	COSMIC	SRSPLKIVK	DEG_APCC_DBOX_1	0.3056
p.S94R	SIDM00872	Breast Carcinoma	GDSC	SRSPLKIVK	DEG_APCC_DBOX_1	0.6944
p.S94R	ACH-000859	Breast Cancer	CCLE	SRSPLKIVK	DEG_APCC_DBOX_1	0.6944
p.S94R	HCC1954	breast	COSMIC	SRSPLKIVK	DEG_APCC_DBOX_1	0.6944
p.S93N	SIDM00217	Colorectal Carcinoma	GDSC	SRSPLKIVK	DEG_APCC_DBOX_1	0.6667
p.S93N	ACH-000999	Colon/Colorectal Cancer	CCLE	SRSPLKIVK	DEG_APCC_DBOX_1	0.6667
p.S93N	SNU-1040	large_intestine	COSMIC	SRSPLKIVK	DEG_APCC_DBOX_1	0.6667
p.D102N	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	SRSPLKIVK	DEG_APCC_DBOX_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2J2	Band 4.1-like protein 3	DEG_APCC_DBOX_1	97:105	SRSPLKIVK	APC,CDC20,FZR1	0.9891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons