DegronMD

Uniprot ID: Q9Y2J2

Source protein: Band 4.1-like protein 3

Source gene: EPB41L3

Class: DEG_APCC_KENBOX_2

Location: 532:536

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9125

ASA_SCORE: 109.4

COIL: 0.8182

CONS_SCORE: 0.5433

DSS_SCORE: 0.477

HELIX: 0.1442

FCONS_SCORE: 0.9651

RIG_SCORE: 0.7228

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L539R	TCGA-06-5416	GBM	TCGA	CKEND	DEG_APCC_KENBOX_2	0.25
p.L539R	DO10880	GBM	ICGC	CKEND	DEG_APCC_KENBOX_2	0.25
p.T526I	TCGA-A5-A0G1	UCEC	TCGA	CKEND	DEG_APCC_KENBOX_2	0.1667
p.T526I	DO42472	UCEC	ICGC	CKEND	DEG_APCC_KENBOX_2	0.1667
p.R529H	TCGA-AX-A2HC	UCEC	TCGA	CKEND	DEG_APCC_KENBOX_2	0.25
p.R529H	DO41572	UCEC	ICGC	CKEND	DEG_APCC_KENBOX_2	0.25
p.S524T	TCGA-CK-4951	COAD	TCGA	CKEND	DEG_APCC_KENBOX_2	0.1111
p.S524T	DO10582	COAD	ICGC	CKEND	DEG_APCC_KENBOX_2	0.1111
p.K533E	TCGA-D7-A4YY	STAD	TCGA	CKEND	DEG_APCC_KENBOX_2	0.7022
p.K533E	DO47733	STAD	ICGC	CKEND	DEG_APCC_KENBOX_2	0.7022
p.C537F	TCGA-HU-A4G3	STAD	TCGA	CKEND	DEG_APCC_KENBOX_2	0.3056
p.C537F	DO47807	STAD	ICGC	CKEND	DEG_APCC_KENBOX_2	0.3056
p.R529C	TCGA-IN-A6RP	STAD	TCGA	CKEND	DEG_APCC_KENBOX_2	0.25
p.R529C	DO51741	STAD	ICGC	CKEND	DEG_APCC_KENBOX_2	0.25
p.P540T	TCGA-J4-8198	PRAD	TCGA	CKEND	DEG_APCC_KENBOX_2	0.2222
p.P540T	DO36303	PRAD	ICGC	CKEND	DEG_APCC_KENBOX_2	0.2222
p.T534A	DO222439	BTCA	ICGC	CKEND	DEG_APCC_KENBOX_2	0.7139
p.A536T	DO8103	COAD	ICGC	CKEND	DEG_APCC_KENBOX_2	0.7139
p.A536T	DO230312	COCA	ICGC	CKEND	DEG_APCC_KENBOX_2	0.7139
p.G541D	DO234401	ESAD	ICGC	CKEND	DEG_APCC_KENBOX_2	0.1944
p.T526M	DO16276	KIRC	ICGC	CKEND	DEG_APCC_KENBOX_2	0.1667
p.G532R	DO50206	LGG	ICGC	CKEND	DEG_APCC_KENBOX_2	0.7568
p.D522E	DO229038	LICA	ICGC	CKEND	DEG_APCC_KENBOX_2	0.0556
p.E527D	DO50958	LICA	ICGC	CKEND	DEG_APCC_KENBOX_2	0.1944
p.T526K	DO52256	LIHC	ICGC	CKEND	DEG_APCC_KENBOX_2	0.1667
p.E538Q	DO23666	LUAD	ICGC	CKEND	DEG_APCC_KENBOX_2	0.2778
p.D540E	DO231149	LUSC	ICGC	CKEND	DEG_APCC_KENBOX_2	0.2222
p.A545E	DO219193	LUSC	ICGC	CKEND	DEG_APCC_KENBOX_2	0.0833
p.S539L	DO232863	NACA	ICGC	CKEND	DEG_APCC_KENBOX_2	0.25
p.D531E	DO48973	PBCA	ICGC	CKEND	DEG_APCC_KENBOX_2	0.3056
p.R525C	DO219253	PRAD	ICGC	CKEND	DEG_APCC_KENBOX_2	0.1389
p.R525C	DO38715	STAD	ICGC	CKEND	DEG_APCC_KENBOX_2	0.1389
p.R525C	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	CKEND	DEG_APCC_KENBOX_2	0.1389
p.P544L	SIDM02049	Pancreatic Carcinoma	GDSC	CKEND	DEG_APCC_KENBOX_2	0.1111
p.P544L	SIDM00545	Melanoma	GDSC	CKEND	DEG_APCC_KENBOX_2	0.1111
p.N535S	SIDM00596	Endometrial Carcinoma	GDSC	CKEND	DEG_APCC_KENBOX_2	0.7069
p.N535S	ACH-001517	Endometrial/Uterine Cancer	CCLE	CKEND	DEG_APCC_KENBOX_2	0.7069
p.N535S	HEC-1	endometrium	COSMIC	CKEND	DEG_APCC_KENBOX_2	0.7069
p.P525H	SIDM01617	Endometrial Carcinoma	GDSC	CKEND	DEG_APCC_KENBOX_2	0.1389
p.P525H	ACH-000994	Endometrial/Uterine Cancer	CCLE	CKEND	DEG_APCC_KENBOX_2	0.1389
p.C532Y	SIDM01749	Osteosarcoma	GDSC	CKEND	DEG_APCC_KENBOX_2	0.5976
p.C532Y	ACH-000340	Non-Cancerous	CCLE	CKEND	DEG_APCC_KENBOX_2	0.5976
p.R525H	KMH-2	thyroid	COSMIC	CKEND	DEG_APCC_KENBOX_2	0.1389
p.Y541F	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	CKEND	DEG_APCC_KENBOX_2	0.1944
p.A535V	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	CKEND	DEG_APCC_KENBOX_2	0.6936
p.A529T	SK-N-AS	autonomic_ganglia	COSMIC	CKEND	DEG_APCC_KENBOX_2	0.25
p.S546R	SK-MES-1	lung	COSMIC	CKEND	DEG_APCC_KENBOX_2	0.0556
p.V532M	SU-DHL-6	haematopoietic_and_lymphoid_tissue	COSMIC	CKEND	DEG_APCC_KENBOX_2	0.7208
p.A543T	COLO-783	skin	COSMIC	CKEND	DEG_APCC_KENBOX_2	0.1389
p.A535T	SNG-M	endometrium	COSMIC	CKEND	DEG_APCC_KENBOX_2	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: CKEND

Degron related mutations and impact score

Drug responses associated with EPB41L3 mutations

All proteins holding degron of CKEND

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2J2	Band 4.1-like protein 3	DEG_APCC_KENBOX_2	532:536	CKEND	APC,CDC20,FZR1	0.9125	More...