DegronMD

Uniprot ID: Q9Y2J2

Source protein: Band 4.1-like protein 3

Source gene: EPB41L3

Class: LIG_APCC_ABBAyCdc20_2

Location: 1071:1077

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.986

ASA_SCORE: 72.8857

COIL: 0.1656

CONS_SCORE: 0.6438

DSS_SCORE: 0.6036

HELIX: 0.0087

FCONS_SCORE: 1.3145

RIG_SCORE: 0.7667

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1068T	TCGA-69-7980	LUAD	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	0.6944
p.M1067I	TCGA-85-8580	LUSC	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	0.2222
p.K1061T	TCGA-A4-7997	KIRP	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	0.5
p.K1071N	TCGA-AZ-6598	COAD	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	0.6918
p.K1071N	TCGA-BR-8363	STAD	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	0.6918
p.K1071N	TCGA-R5-A7ZE	STAD	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	0.6918
p.K1071N	TCGA-VQ-A8PJ	STAD	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	0.6918
p.K1071N	TCGA-VQ-A91V	STAD	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	0.6918
p.Q1063P	TCGA-B5-A5OC	UCEC	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E1079D	TCGA-BA-A4II	HNSC	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E1079D	TCGA-BR-8368	STAD	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.S1068L	TCGA-GC-A3I6	BLCA	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	0.6944
p.K1061R	TCGA-IN-A6RJ	STAD	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	0.5
p.H1064N	TCGA-NC-A5HR	LUSC	TCGA	KVVVHKE	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2J2	Band 4.1-like protein 3	LIG_APCC_ABBAyCdc20_2	1071:1077	KVVVHKE	APC,CDC20,FZR1	0.986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons