DegronMD - Q96D42(HAVCR1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T206K	TCGA-13-1481	OV	TCGA	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.7306
p.T206K	DO31789	OV	ICGC	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.7306
p.T163M	TCGA-16-0848	GBM	TCGA	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7423
p.T163M	DO12196	GBM	ICGC	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.7423
p.T148N	TCGA-17-Z059	LUAD	TCGA	VRTST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.7055
p.I134V	TCGA-2Y-A9HA	LIHC	TCGA	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation altering degron motif	0.5965
p.I134V	DO219539	LIHC	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation altering degron motif	0.5965
p.T199A	TCGA-44-8117	LUAD	TCGA	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7139
p.T199A	DO24028	LUAD	ICGC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7139
p.P191Q	TCGA-63-A5MT	LUSC	TCGA	VPTTT	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.5924
p.P191Q	DO219163	LUSC	ICGC	VPTTT	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.5924
p.T152M	TCGA-99-8033	LUAD	TCGA	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7423
p.T152M	TCGA-CV-5439	HNSC	TCGA	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7423
p.T152M	DO14200	HNSC	ICGC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7423
p.T152M	DO23726	LUAD	ICGC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7423
p.T152M	DO224594	LUSC	ICGC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7423
p.T152M	DO227527	PBCA	ICGC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7423
p.V141I	TCGA-A5-A0G2	UCEC	TCGA	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.1944
p.V141I	TCGA-A5-A0G2	UCEC	TCGA	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.25
p.V141I	TCGA-A5-A0G2	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0833
p.V141I	TCGA-AZ-6598	COAD	TCGA	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.1944
p.V141I	TCGA-AZ-6598	COAD	TCGA	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.25
p.V141I	TCGA-AZ-6598	COAD	TCGA	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0833
p.V141I	TCGA-D1-A0ZO	UCEC	TCGA	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.1944
p.V141I	TCGA-D1-A0ZO	UCEC	TCGA	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.25
p.V141I	TCGA-D1-A0ZO	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0833
p.V141I	DO10276	COAD	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.1944
p.V141I	DO10276	COAD	ICGC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.25
p.V141I	DO10276	COAD	ICGC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0833
p.V141I	DO233205	GACA	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.1944
p.V141I	DO233205	GACA	ICGC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.25
p.V141I	DO233205	GACA	ICGC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0833
p.V141I	DO41927	UCEC	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.1944
p.V141I	DO41927	UCEC	ICGC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.25
p.V141I	DO41927	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0833
p.V141I	DO41235	UCEC	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.1944
p.V141I	DO41235	UCEC	ICGC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.25
p.V141I	DO41235	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0833
p.T130M	TCGA-AA-3877	COAD	TCGA	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation altering degron motif	0.6312
p.T130M	TCGA-EY-A549	UCEC	TCGA	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation altering degron motif	0.6312
p.T130M	DO7855	COAD	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation altering degron motif	0.6312
p.T130M	DO48174	UCEC	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation altering degron motif	0.6312
p.R145Q	TCGA-AG-A002	READ	TCGA	VRTST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.6218
p.R145Q	TCGA-EE-A2GD	SKCM	TCGA	VRTST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.6218
p.R145Q	DO229459	SKCA	ICGC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.6218
p.R145Q	DO37603	SKCM	ICGC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.6218
p.T140I	TCGA-B0-4698	KIRC	TCGA	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.2222
p.T140I	TCGA-B0-4698	KIRC	TCGA	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.2222
p.T140I	TCGA-B0-4698	KIRC	TCGA	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0556
p.T140I	DO20368	KIRC	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.2222
p.T140I	DO20368	KIRC	ICGC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.2222
p.T140I	DO20368	KIRC	ICGC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0556
p.S147R	TCGA-BR-8363	STAD	TCGA	VRTST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.7427
p.S147R	DO47837	STAD	ICGC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.7427
p.S189I	TCGA-BS-A0UF	UCEC	TCGA	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.3056
p.S189I	TCGA-BS-A0UF	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.3056
p.S189I	TCGA-BS-A0UF	UCEC	TCGA	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1111
p.S189I	DO41488	UCEC	ICGC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.3056
p.S189I	DO41488	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.3056
p.S189I	DO41488	UCEC	ICGC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1111
p.T146R	TCGA-CV-6938	HNSC	TCGA	VRTST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.7876
p.T146R	DO14462	HNSC	ICGC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.7876
p.T154M	TCGA-D5-6930	COAD	TCGA	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7423
p.T154M	DO10550	COAD	ICGC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7423
p.T154M	SIDM02016	Colorectal Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7423
p.V204L	TCGA-D6-A4ZB	HNSC	TCGA	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.5654
p.V204L	DO44446	HNSC	ICGC	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.5654
p.T193P	TCGA-DU-6392	LGG	TCGA	VPTTT	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.7031
p.T193P	DO22237	LGG	ICGC	VPTTT	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.7031
p.V208I	TCGA-EB-A431	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1389
p.V208I	TCGA-EB-A431	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.3056
p.V208I	DO37671	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.1389
p.V208I	DO37671	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.3056
p.P197L	TCGA-EE-A3JD	SKCM	TCGA	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7582
p.P197L	DO50299	SKCM	ICGC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7582
p.P203S	TCGA-EJ-5527	PRAD	TCGA	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.6752
p.P203S	TCGA-YG-AA3N	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.6752
p.P203S	DO36322	PRAD	ICGC	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.6752
p.P203S	DO51298	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.6752
p.T188M	TCGA-EO-A22U	UCEC	TCGA	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7423
p.T188M	TCGA-OR-A5LM	ACC	TCGA	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7423
p.T188M	DO50406	ESAD	ICGC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7423
p.T188M	DO43755	UCEC	ICGC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7423
p.M182I	TCGA-EO-A22U	UCEC	TCGA	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.2778
p.M182I	TCGA-EO-A22U	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1111
p.M182I	TCGA-UT-A88C	MESO	TCGA	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.2778
p.M182I	TCGA-UT-A88C	MESO	TCGA	VPTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1111
p.M182I	DO43755	UCEC	ICGC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.2778
p.M182I	DO43755	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1111
p.T177A	TCGA-F1-A448	STAD	TCGA	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1389
p.T177A	DO48044	STAD	ICGC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1389
p.E123K	TCGA-FR-A726	SKCM	TCGA	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.1667
p.E123K	DO222632	MELA	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.1667
p.E123K	DO48665	SKCM	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.1667
p.R145L	TCGA-L9-A8F4	LUAD	TCGA	VRTST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.7316
p.R145L	DO49876	LUAD	ICGC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.7316
p.P197Q	TCGA-MP-A4TA	LUAD	TCGA	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7035
p.P197Q	DO45314	LUAD	ICGC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7035
p.V120I	TCGA-QQ-A5V9	SARC	TCGA	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.0833
p.V120I	DO220245	SARC	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.0833
p.M158T	DO224820	COCA	ICGC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.0556
p.M158T	DO224820	COCA	ICGC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2222
p.M158T	DO224820	COCA	ICGC	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.25
p.M158T	DO52361	LUSC	ICGC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.0556
p.M158T	DO52361	LUSC	ICGC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2222
p.M158T	DO52361	LUSC	ICGC	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.25
p.S201N	DO222501	COCA	ICGC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7069
p.T207A	DO229010	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.7139
p.T207A	DO229005	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.7139
p.T207A	DO234285	ESAD	ICGC	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.7139
p.T207A	DO230934	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.7139
p.T207A	DO231196	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.7139
p.T207A	DO231201	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation altering degron motif	0.7139
p.L179P	DO229010	COCA	ICGC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1944
p.L179P	DO229013	COCA	ICGC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1944
p.L179P	DO229016	COCA	ICGC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1944
p.L179P	DO229003	COCA	ICGC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1944
p.L179P	DO229005	COCA	ICGC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1944
p.S195R	DO223007	ESCA	ICGC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1389
p.S195R	DO223007	ESCA	ICGC	VPTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.3056
p.S195R	DO223007	ESCA	ICGC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.2778
p.S195R	DO223007	ESCA	ICGC	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.1111
p.T174M	DO222549	ESCA	ICGC	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0833
p.T174M	DO222549	ESCA	ICGC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.T174M	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0833
p.T174M	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.T174M	SIDM00210	Ovarian Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0833
p.T174M	SIDM00210	Ovarian Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.T174M	SIDM01112	Osteosarcoma	GDSC	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0833
p.T174M	SIDM01112	Osteosarcoma	GDSC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.T174M	SIDM00068	Colorectal Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0833
p.T174M	SIDM00068	Colorectal Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.T174M	SIDM00257	Neuroblastoma	GDSC	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0833
p.T174M	SIDM00257	Neuroblastoma	GDSC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.T186M	DO222618	ESCA	ICGC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7423
p.T186M	SIDM00633	Breast Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7423
p.T186M	SIDM00690	Head and Neck Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7423
p.T186M	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7423
p.T186M	SIDM00849	Kidney Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7423
p.T186M	SIDM00875	Breast Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7423
p.T186M	SIDM00930	Osteosarcoma	GDSC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7423
p.T186M	SIDM00954	Breast Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7423
p.T186M	SIDM00808	Burkitt's Lymphoma	GDSC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7423
p.T186M	SIDM01173	Rhabdomyosarcoma	GDSC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7423
p.T186M	SIDM01409	Bladder Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7423
p.T186M	SIDM01254	Burkitt's Lymphoma	GDSC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7423
p.V120A	DO233270	GACA	ICGC	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.0833
p.T181K	DO228976	LICA	ICGC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.25
p.T181K	DO228976	LICA	ICGC	VPTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.0833
p.T180K	DO229038	LICA	ICGC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.2222
p.T180K	DO229038	LICA	ICGC	VPTTT	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.0556
p.T146K	DO229041	LICA	ICGC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.7306
p.T154K	DO229006	LICA	ICGC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7306
p.S147C	DO50972	LICA	ICGC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.7541
p.P214T	DO220902	MELA	ICGC	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.1389
p.M215L	DO222710	MELA	ICGC	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.1111
p.T148S	DO51491	PACA	ICGC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation altering degron motif	0.6005
p.M158I	DO229272	THCA	ICGC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.0556
p.M158I	DO229272	THCA	ICGC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2222
p.M158I	DO229272	THCA	ICGC	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.25
p.M158I	DO229245	THCA	ICGC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.0556
p.M158I	DO229245	THCA	ICGC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2222
p.M158I	DO229245	THCA	ICGC	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.25
p.T200R	DO229250	THCA	ICGC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01137	Pancreatic Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00994	T-Lymphoblastic Leukemia	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00331	B-Lymphoblastic Leukemia	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00524	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00630	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00625	Other Sarcomas	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01233	Colorectal Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01183	Other Solid Cancers	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01062	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00789	Colorectal Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00643	Non-Cancerous	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00200	Ewing's Sarcoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00308	Chronic Myelogenous Leukemia	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00885	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00269	Ewing's Sarcoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01078	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01168	Colorectal Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00057	Neuroblastoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00748	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00474	Ovarian Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00719	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01044	Other Solid Cancers	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00568	Gastric Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00092	Ovarian Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00965	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00879	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01110	Hepatocellular Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00391	Plasma Cell Myeloma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00767	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00035	Thyroid Gland Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00342	T-Lymphoblastic Leukemia	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00259	Neuroblastoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01185	Other Solid Cancers	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00893	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00989	Bladder Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01061	Oral Cavity Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00469	Pancreatic Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00218	Thyroid Gland Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00685	Glioblastoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01193	Glioma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00986	Head and Neck Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00213	Thyroid Gland Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00721	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00528	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01083	Oral Cavity Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00519	Mesothelioma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00774	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00760	Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00184	Melanoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00628	Breast Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01629	Melanoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01682	Gastric Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01412	Oral Cavity Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01394	Kidney Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01752	Pancreatic Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM01587	Bladder Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T200R	SIDM00497	Colorectal Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation altering degron motif	0.7876
p.T194M	SIDM01040	Ovarian Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.7423
p.T194M	SIDM00878	Breast Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.7423
p.T194M	SIDM00785	Acute Myeloid Leukemia	GDSC	VPTTT	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.7423
p.P126L	SIDM00504	Glioma	GDSC	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.25
p.P126L	ACH-001126	Brain Cancer	CCLE	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.25
p.P126L	MOG-G-UVW	central nervous system	COSMIC	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.25
p.T210A	SIDM00120	Prostate Carcinoma	GDSC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.0833
p.T210A	SIDM00120	Prostate Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.25
p.T210A	ACH-000979	Prostate Cancer	CCLE	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.0833
p.T210A	ACH-000979	Prostate Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.25
p.T210A	DU-145	prostate	COSMIC	PTTTS	DEG_SPOP_SBC_1	197:201	Mutation rewiring degron network	0.0833
p.T210A	DU-145	prostate	COSMIC	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.25
p.P213S	SIDM00630	Breast Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	203:207	Mutation rewiring degron network	0.1667
p.T160N	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1667
p.T160N	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.3056
p.T160N	NCI-H2135	lung	COSMIC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1667
p.T160N	NCI-H2135	lung	COSMIC	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.3056
p.T155N	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1389
p.T155N	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.3056
p.T155N	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1667
p.T155N	ACH-001363	Lung Cancer	CCLE	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1389
p.T155N	ACH-001363	Lung Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.3056
p.T155N	ACH-001363	Lung Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1667
p.T155N	NCI-H2135	lung	COSMIC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1389
p.T155N	NCI-H2135	lung	COSMIC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.3056
p.T155N	NCI-H2135	lung	COSMIC	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1667
p.T176M	SIDM00429	B-Lymphoblastic Leukemia	GDSC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.T176M	ACH-000938	Leukemia	CCLE	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.T176M	NALM-6	haematopoietic and lymphoid tissue	COSMIC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.V190I	SIDM01088	Endometrial Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.7076
p.V190I	ACH-000965	Endometrial/Uterine Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.7076
p.V190I	ACH-000979	Prostate Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.7076
p.V190I	RL95-2	endometrium	COSMIC	VPTTT	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.7076
p.T142M	SIDM00837	Colorectal Carcinoma	GDSC	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.1667
p.T142M	SIDM00837	Colorectal Carcinoma	GDSC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.2778
p.T142M	SIDM00837	Colorectal Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1111
p.T142M	ACH-000958	Colon/Colorectal Cancer	CCLE	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.1667
p.T142M	ACH-000958	Colon/Colorectal Cancer	CCLE	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.2778
p.T142M	ACH-000958	Colon/Colorectal Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1111
p.T142M	SW48	large intestine	COSMIC	VTTTPIVT	DEG_SCF_FBW7_1	129:136	Mutation rewiring degron network	0.1667
p.T142M	SW48	large intestine	COSMIC	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.2778
p.T142M	SW48	large intestine	COSMIC	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1111
p.T169A	SIDM01660	Kidney Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.2222
p.T155P	ACH-001433	Sarcoma	CCLE	VRTST	DEG_SPOP_SBC_1	144:148	Mutation rewiring degron network	0.1389
p.T155P	ACH-001433	Sarcoma	CCLE	VPTTT	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.3056
p.T155P	ACH-001433	Sarcoma	CCLE	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.1667
p.T174K	JSC-1	haematopoietic and lymphoid tissue	COSMIC	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0833
p.T174K	JSC-1	haematopoietic and lymphoid tissue	COSMIC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556
p.T174K	UACC-893	breast	COSMIC	VPTTT	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0833
p.T174K	UACC-893	breast	COSMIC	VSTTT	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HAVCR1

UniProt ID: Q96D42

Entrez ID: 26762

Protein name: Hepatitis A virus cellular receptor 1 (HAVcr-1) (Kidney injury molecule 1) (KIM-1) (T-cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T-cell immunoglobulin mucin receptor 1) (TIM) (TIM-1) (T-cell membrane protein 1) (CD antigen CD365)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HAVCR1 in