DegronMD

Uniprot ID: Q96D42

Source protein: Hepatitis A virus cellular receptor 1

Source gene: HAVCR1

Class: DEG_SPOP_SBC_1

Location: 150:154

E3 ligase: SPOP

DEGRON score: 0.9885

ASA_SCORE: 98.7

COIL: 0.964

CONS_SCORE: 0.2227

DSS_SCORE: 0.4768

HELIX: 0.0104

FCONS_SCORE: 0.994

RIG_SCORE: 0.7928

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T152M	TCGA-99-8033	LUAD	TCGA	VPTTT	DEG_SPOP_SBC_1	0.7423
p.T152M	TCGA-CV-5439	HNSC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.7423
p.T152M	DO14200	HNSC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7423
p.T152M	DO23726	LUAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7423
p.T152M	DO224594	LUSC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7423
p.T152M	DO227527	PBCA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7423
p.V141I	TCGA-A5-A0G2	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.0833
p.V141I	TCGA-AZ-6598	COAD	TCGA	VPTTT	DEG_SPOP_SBC_1	0.0833
p.V141I	TCGA-D1-A0ZO	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.0833
p.V141I	DO10276	COAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.0833
p.V141I	DO233205	GACA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.0833
p.V141I	DO41927	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.0833
p.V141I	DO41235	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.0833
p.T140I	TCGA-B0-4698	KIRC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.0556
p.T140I	DO20368	KIRC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.0556
p.T154M	TCGA-D5-6930	COAD	TCGA	VPTTT	DEG_SPOP_SBC_1	0.7423
p.T154M	DO10550	COAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7423
p.T154M	SIDM02016	Colorectal Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.7423
p.M158T	DO224820	COCA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2222
p.M158T	DO52361	LUSC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2222
p.T154K	DO229006	LICA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7306
p.M158I	DO229272	THCA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2222
p.M158I	DO229245	THCA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2222
p.T160N	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.1667
p.T160N	NCI-H2135	lung	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.1667
p.T155N	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.3056
p.T155N	ACH-001363	Lung Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	0.3056
p.T155N	NCI-H2135	lung	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.3056
p.T142M	SIDM00837	Colorectal Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.1111
p.T142M	ACH-000958	Colon/Colorectal Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	0.1111
p.T142M	SW48	large_intestine	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.1111
p.T155P	ACH-001433	Sarcoma	CCLE	VPTTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75829	Leukocyte cell-derived chemotaxin 1	DEG_SPOP_SBC_1	221:225	VPTTT	SPOP	0.9724	More...
P22105	Tenascin-X	DEG_SPOP_SBC_1	2834:2838	VPTTT	SPOP	0.8867	More...
P98171	Rho GTPase-activating protein 4	DEG_SPOP_SBC_1	200:204	VPTTT	SPOP	0.9213	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5806:5810	VPTTT	SPOP	0.9863	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11618:11622	VPTTT	SPOP	0.7076	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	150:154	VPTTT	SPOP	0.9885	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	161:165	VPTTT	SPOP	0.986	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	190:194	VPTTT	SPOP	0.9092	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2051:2055	VPTTT	SPOP	0.9951	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3308:3312	VPTTT	SPOP	0.993	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3865:3869	VPTTT	SPOP	0.9882	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4593:4597	VPTTT	SPOP	0.9609	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SPOP_SBC_1	625:629	VPTTT	SPOP	0.8307	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	543:547	VPTTT	SPOP	0.7751	More...
O94880	PHD finger protein 14	DEG_SPOP_SBC_1	166:170	VPTTT	SPOP	0.991	More...
Q8WW62	Transmembrane emp24 domain-containing protein 6	DEG_SPOP_SBC_1	229:233	VPTTT	SPOP	0.7106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPTTT

Degron related mutations and impact score

Drug responses associated with HAVCR1 mutations

All proteins holding degron of VPTTT