DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 11618:11622

E3 ligase: SPOP

DEGRON score: 0.7076

ASA_SCORE: 94.76

COIL: 0.9418

CONS_SCORE: 0

DSS_SCORE: 0.6283

HELIX: 0.0062

FCONS_SCORE: 0

RIG_SCORE: 0.6868

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R11615M	TCGA-A5-A0G2	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.25
p.R11615M	DO41235	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.25
p.V11631A	TCGA-BG-A222	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.0833
p.V11631A	DO42977	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.0833
p.I11623T	TCGA-E6-A1M0	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.3056
p.I11623T	DO43682	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.3056
p.G11629E	TCGA-EB-A24D	SKCM	TCGA	VPTTT	DEG_SPOP_SBC_1	0.1389
p.G11629E	DO37440	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1389
p.R11615T	TCGA-EE-A3AB	SKCM	TCGA	VPTTT	DEG_SPOP_SBC_1	0.25
p.R11615T	DO222670	MELA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.25
p.R11615T	DO38057	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	0.25
p.P11628Q	DO229029	LICA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1667
p.T11620N	DO229026	LICA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7055
p.V11612L	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.1667
p.V11612L	ACH-000789	Lung Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	0.1667
p.V11612L	NCI-H810	lung	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75829	Leukocyte cell-derived chemotaxin 1	DEG_SPOP_SBC_1	221:225	VPTTT	SPOP	0.9724	More...
P22105	Tenascin-X	DEG_SPOP_SBC_1	2834:2838	VPTTT	SPOP	0.8867	More...
P98171	Rho GTPase-activating protein 4	DEG_SPOP_SBC_1	200:204	VPTTT	SPOP	0.9213	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5806:5810	VPTTT	SPOP	0.9863	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11618:11622	VPTTT	SPOP	0.7076	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	150:154	VPTTT	SPOP	0.9885	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	161:165	VPTTT	SPOP	0.986	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	190:194	VPTTT	SPOP	0.9092	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2051:2055	VPTTT	SPOP	0.9951	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3308:3312	VPTTT	SPOP	0.993	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3865:3869	VPTTT	SPOP	0.9882	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4593:4597	VPTTT	SPOP	0.9609	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SPOP_SBC_1	625:629	VPTTT	SPOP	0.8307	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	543:547	VPTTT	SPOP	0.7751	More...
O94880	PHD finger protein 14	DEG_SPOP_SBC_1	166:170	VPTTT	SPOP	0.991	More...
Q8WW62	Transmembrane emp24 domain-containing protein 6	DEG_SPOP_SBC_1	229:233	VPTTT	SPOP	0.7106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons