DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 3865:3869

E3 ligase: SPOP

DEGRON score: 0.9882

ASA_SCORE: 90.1

COIL: 0.9144

CONS_SCORE: 0.2899

DSS_SCORE: 0.5916

HELIX: 0.014

FCONS_SCORE: 1.1262

RIG_SCORE: 0.7166

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3857T	TCGA-55-A490	LUAD	TCGA	VPTTT	DEG_SPOP_SBC_1	0.1111
p.T3867A	TCGA-AZ-4315	COAD	TCGA	VPTTT	DEG_SPOP_SBC_1	0.7139
p.T3874K	TCGA-BH-A42V	BRCA	TCGA	VPTTT	DEG_SPOP_SBC_1	0.1944
p.T3868S	TCGA-DU-A7T6	LGG	TCGA	VPTTT	DEG_SPOP_SBC_1	0.6005
p.V3865M	TCGA-HT-7480	LGG	TCGA	VPTTT	DEG_SPOP_SBC_1	0.7208
p.A3860V	TCGA-NH-A5IV	COAD	TCGA	VPTTT	DEG_SPOP_SBC_1	0.1944
p.S3857Y	DO49964	CESC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1111
p.A3863V	DO49095	COAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7222
p.T3870A	DO8842	COAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.3056
p.T3871I	DO230347	COCA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2778
p.T3872A	DO223071	ESCA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.25
p.T3871S	DO51814	LGG	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2778
p.V3868M	DO22639	LGG	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7208
p.P3860T	DO24596	LUAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1944
p.P3869L	DO218859	SKCA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7582
p.T3870N	SIDM00845	Burkitt's Lymphoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.3056
p.T3870N	SIDM00846	Cervical Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.3056
p.T3870N	SIDM00760	Small Cell Lung Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.3056
p.T3870N	SIDM01525	Acute Myeloid Leukemia	GDSC	VPTTT	DEG_SPOP_SBC_1	0.3056
p.T3874I	SIDM00150	Colorectal Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.1944
p.T3874I	ACH-000969	Colon/Colorectal Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	0.1944
p.T3874I	KM12	large_intestine	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75829	Leukocyte cell-derived chemotaxin 1	DEG_SPOP_SBC_1	221:225	VPTTT	SPOP	0.9724	More...
P22105	Tenascin-X	DEG_SPOP_SBC_1	2834:2838	VPTTT	SPOP	0.8867	More...
P98171	Rho GTPase-activating protein 4	DEG_SPOP_SBC_1	200:204	VPTTT	SPOP	0.9213	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5806:5810	VPTTT	SPOP	0.9863	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11618:11622	VPTTT	SPOP	0.7076	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	150:154	VPTTT	SPOP	0.9885	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	161:165	VPTTT	SPOP	0.986	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	190:194	VPTTT	SPOP	0.9092	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2051:2055	VPTTT	SPOP	0.9951	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3308:3312	VPTTT	SPOP	0.993	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3865:3869	VPTTT	SPOP	0.9882	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4593:4597	VPTTT	SPOP	0.9609	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SPOP_SBC_1	625:629	VPTTT	SPOP	0.8307	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	543:547	VPTTT	SPOP	0.7751	More...
O94880	PHD finger protein 14	DEG_SPOP_SBC_1	166:170	VPTTT	SPOP	0.991	More...
Q8WW62	Transmembrane emp24 domain-containing protein 6	DEG_SPOP_SBC_1	229:233	VPTTT	SPOP	0.7106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons