DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 5806:5810

E3 ligase: SPOP

DEGRON score: 0.9863

ASA_SCORE: 87.28

COIL: 0.8902

CONS_SCORE: 0

DSS_SCORE: 0.5599

HELIX: 0.0128

FCONS_SCORE: 0

RIG_SCORE: 0.7588

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E5813D	TCGA-BA-6869	HNSC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.25
p.E5813D	DO14250	HNSC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.25
p.T5810N	TCGA-ER-A42L	SKCM	TCGA	VPTTT	DEG_SPOP_SBC_1	0.8166
p.T5810N	DO223910	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	0.8166
p.S5815F	TCGA-YG-AA3O	SKCM	TCGA	VPTTT	DEG_SPOP_SBC_1	0.1944
p.S5815F	DO51299	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1944
p.E5818A	DO50357	ESAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1111
p.P5807L	DO233764	GACA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.6471
p.L5803F	DO222494	MELA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.25
p.E5805G	DO229456	SKCA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.3056
p.T5797R	ACH-001623	Brain Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	0.0833
p.E5798G	ACH-002287	Colon/Colorectal Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	0.1111
p.E5798G	NCI-H630	large_intestine	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75829	Leukocyte cell-derived chemotaxin 1	DEG_SPOP_SBC_1	221:225	VPTTT	SPOP	0.9724	More...
P22105	Tenascin-X	DEG_SPOP_SBC_1	2834:2838	VPTTT	SPOP	0.8867	More...
P98171	Rho GTPase-activating protein 4	DEG_SPOP_SBC_1	200:204	VPTTT	SPOP	0.9213	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5806:5810	VPTTT	SPOP	0.9863	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11618:11622	VPTTT	SPOP	0.7076	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	150:154	VPTTT	SPOP	0.9885	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	161:165	VPTTT	SPOP	0.986	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	190:194	VPTTT	SPOP	0.9092	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2051:2055	VPTTT	SPOP	0.9951	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3308:3312	VPTTT	SPOP	0.993	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3865:3869	VPTTT	SPOP	0.9882	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4593:4597	VPTTT	SPOP	0.9609	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SPOP_SBC_1	625:629	VPTTT	SPOP	0.8307	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	543:547	VPTTT	SPOP	0.7751	More...
O94880	PHD finger protein 14	DEG_SPOP_SBC_1	166:170	VPTTT	SPOP	0.991	More...
Q8WW62	Transmembrane emp24 domain-containing protein 6	DEG_SPOP_SBC_1	229:233	VPTTT	SPOP	0.7106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons