DegronMD - P22105(TNXB)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T2614S	TCGA-05-4390	LUAD	TCGA	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation altering degron motif	0.6005
p.T2614S	DO23562	LUAD	ICGC	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation altering degron motif	0.6005
p.S2508N	TCGA-66-2767	LUSC	TCGA	VDETPSPT	DEG_SCF_FBW7_1	2503:2510	Mutation altering degron motif	0.5958
p.S2508N	DO26713	LUSC	ICGC	VDETPSPT	DEG_SCF_FBW7_1	2503:2510	Mutation altering degron motif	0.5958
p.P2629A	TCGA-AA-3502	COAD	TCGA	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.1111
p.P2629A	DO7775	COAD	ICGC	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.1111
p.A2604V	TCGA-AJ-A2QO	UCEC	TCGA	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.1944
p.A2604V	DO229234	THCA	ICGC	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.1944
p.A2604V	DO229245	THCA	ICGC	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.1944
p.A2604V	DO42177	UCEC	ICGC	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.1944
p.L2845I	TCGA-AX-A06F	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	2834:2838	Mutation rewiring degron network	0.1389
p.T3036A	TCGA-AX-A2HC	UCEC	TCGA	DEAETTQAVPTM	DEG_COP1_1	3042:3053	Mutation rewiring degron network	0.1667
p.R2844H	TCGA-BR-6452	STAD	TCGA	VPTTT	DEG_SPOP_SBC_1	2834:2838	Mutation substituting flanking lysine	0.2778
p.E2825K	TCGA-DK-A3WW	BLCA	TCGA	VPTTT	DEG_SPOP_SBC_1	2834:2838	Mutation rewiring degron network	0.0833
p.T2620I	TCGA-EB-A3XF	SKCM	TCGA	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation altering degron motif	0.7078
p.T2620I	DO37437	SKCM	ICGC	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation altering degron motif	0.7078
p.P2623L	TCGA-FR-A726	SKCM	TCGA	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.2778
p.P2623L	DO48665	SKCM	ICGC	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.2778
p.R2630C	TCGA-GN-A269	SKCM	TCGA	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.0833
p.R2630C	DO37483	SKCM	ICGC	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.0833
p.E2501K	TCGA-HD-8224	HNSC	TCGA	VDETPSPT	DEG_SCF_FBW7_1	2503:2510	Mutation rewiring degron network	0.2778
p.E2501K	DO15935	HNSC	ICGC	VDETPSPT	DEG_SCF_FBW7_1	2503:2510	Mutation rewiring degron network	0.2778
p.E2501K	ACH-002309	Sarcoma	CCLE	VDETPSPT	DEG_SCF_FBW7_1	2503:2510	Mutation rewiring degron network	0.2778
p.E2501K	SW684	soft tissue	COSMIC	VDETPSPT	DEG_SCF_FBW7_1	2503:2510	Mutation rewiring degron network	0.2778
p.D2610Y	TCGA-L5-A88S	ESCA	TCGA	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation altering degron motif	0.7325
p.E2511K	TCGA-OD-A75X	SKCM	TCGA	VDETPSPT	DEG_SCF_FBW7_1	2503:2510	Mutation rewiring degron network	0.3056
p.E2511K	DO48601	SKCM	ICGC	VDETPSPT	DEG_SCF_FBW7_1	2503:2510	Mutation rewiring degron network	0.3056
p.R2630H	TCGA-WE-AAA3	SKCM	TCGA	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.0833
p.R2630H	DO51295	SKCM	ICGC	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.0833
p.R4023W	DO48444	BLCA	ICGC	PVSTS	DEG_SPOP_SBC_1	4012:4016	Mutation rewiring degron network	0.1389
p.R4023W	NOMO-1	haematopoietic and lymphoid tissue	COSMIC	PVSTS	DEG_SPOP_SBC_1	4012:4016	Mutation rewiring degron network	0.1389
p.E2827K	DO481	BLCA	ICGC	VPTTT	DEG_SPOP_SBC_1	2834:2838	Mutation rewiring degron network	0.1389
p.P3051H	DO550	BLCA	ICGC	DEAETTQAVPTM	DEG_COP1_1	3042:3053	Mutation altering degron motif	0.7694
p.D1354N	DO9346	COAD	ICGC	VDETPSPT	DEG_SCF_FBW7_1	1353:1360	Mutation altering degron motif	0.5821
p.D1354N	ACH-000561	Esophageal Cancer	CCLE	VDETPSPT	DEG_SCF_FBW7_1	1353:1360	Mutation altering degron motif	0.5821
p.D1354N	T-T	oesophagus	COSMIC	VDETPSPT	DEG_SCF_FBW7_1	1353:1360	Mutation altering degron motif	0.5821
p.T1364M	DO233944	GACA	ICGC	VDETPSPT	DEG_SCF_FBW7_1	1353:1360	Mutation rewiring degron network	0.2222
p.P1367S	DO49050	HNSC	ICGC	VDETPSPT	DEG_SCF_FBW7_1	1353:1360	Mutation rewiring degron network	0.1389
p.G2495S	DO229505	LAML	ICGC	VDETPSPT	DEG_SCF_FBW7_1	2503:2510	Mutation rewiring degron network	0.1111
p.G2495S	DO230556	LUSC	ICGC	VDETPSPT	DEG_SCF_FBW7_1	2503:2510	Mutation rewiring degron network	0.1111
p.G2495S	DO231102	LUSC	ICGC	VDETPSPT	DEG_SCF_FBW7_1	2503:2510	Mutation rewiring degron network	0.1111
p.G1363D	DO227504	LAML	ICGC	VDETPSPT	DEG_SCF_FBW7_1	1353:1360	Mutation rewiring degron network	0.25
p.L3063Q	DO50828	LICA	ICGC	DEAETTQAVPTM	DEG_COP1_1	3042:3053	Mutation rewiring degron network	0.0556
p.S3033P	DO22802	LICA	ICGC	DEAETTQAVPTM	DEG_COP1_1	3042:3053	Mutation rewiring degron network	0.0833
p.L2599V	DO23210	LINC	ICGC	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.0556
p.M4004T	DO52365	LUSC	ICGC	PVSTS	DEG_SPOP_SBC_1	4012:4016	Mutation rewiring degron network	0.1111
p.P1370H	DO26886	LUSC	ICGC	VDETPSPT	DEG_SCF_FBW7_1	1353:1360	Mutation rewiring degron network	0.0556
p.P2519L	DO220855	MELA	ICGC	VDETPSPT	DEG_SCF_FBW7_1	2503:2510	Mutation rewiring degron network	0.0833
p.P4025S	DO220902	MELA	ICGC	PVSTS	DEG_SPOP_SBC_1	4012:4016	Mutation rewiring degron network	0.0833
p.P4025S	DO37406	SKCM	ICGC	PVSTS	DEG_SPOP_SBC_1	4012:4016	Mutation rewiring degron network	0.0833
p.P1357S	DO222662	MELA	ICGC	VDETPSPT	DEG_SCF_FBW7_1	1353:1360	Mutation altering degron motif	0.6752
p.R3062H	DO36305	PRAD	ICGC	DEAETTQAVPTM	DEG_COP1_1	3042:3053	Mutation rewiring degron network	0.0833
p.P4025L	DO47469	SKCM	ICGC	PVSTS	DEG_SPOP_SBC_1	4012:4016	Mutation rewiring degron network	0.0833
p.P4025L	DO47368	SKCM	ICGC	PVSTS	DEG_SPOP_SBC_1	4012:4016	Mutation rewiring degron network	0.0833
p.P2824S	DO47542	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	2834:2838	Mutation rewiring degron network	0.0556
p.E1361K	DO51282	SKCM	ICGC	VDETPSPT	DEG_SCF_FBW7_1	1353:1360	Mutation rewiring degron network	0.3056
p.E1355K	DO51282	SKCM	ICGC	VDETPSPT	DEG_SCF_FBW7_1	1353:1360	Mutation altering degron motif	0.591
p.E3041K	DO38123	SKCM	ICGC	DEAETTQAVPTM	DEG_COP1_1	3042:3053	Mutation rewiring degron network	0.3056
p.R2846H	DO38404	STAD	ICGC	VPTTT	DEG_SPOP_SBC_1	2834:2838	Mutation rewiring degron network	0.1111
p.E2515G	DO229224	THCA	ICGC	VDETPSPT	DEG_SCF_FBW7_1	2503:2510	Mutation rewiring degron network	0.1944
p.T3052I	DO43186	UCEC	ICGC	DEAETTQAVPTM	DEG_COP1_1	3042:3053	Mutation altering degron motif	0.7078
p.L2847I	DO41752	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	2834:2838	Mutation rewiring degron network	0.0833
p.T3038A	DO41572	UCEC	ICGC	DEAETTQAVPTM	DEG_COP1_1	3042:3053	Mutation rewiring degron network	0.2222
p.S4014P	DO42480	UCEC	ICGC	PVSTS	DEG_SPOP_SBC_1	4012:4016	Mutation altering degron motif	0.6752
p.R3062C	DO41488	UCEC	ICGC	DEAETTQAVPTM	DEG_COP1_1	3042:3053	Mutation rewiring degron network	0.0833
p.R3045H	SIDM01104	Melanoma	GDSC	DEAETTQAVPTM	DEG_COP1_1	3042:3053	Mutation altering degron motif	0.8244
p.S1361L	SIDM00321	Ovarian Carcinoma	GDSC	VDETPSPT	DEG_SCF_FBW7_1	1353:1360	Mutation rewiring degron network	0.3056
p.R2831C	SIDM00620	Glioblastoma	GDSC	VPTTT	DEG_SPOP_SBC_1	2834:2838	Mutation rewiring degron network	0.25
p.E2842K	SIDM00377	Other Sarcomas	GDSC	VPTTT	DEG_SPOP_SBC_1	2834:2838	Mutation rewiring degron network	0.2222
p.R2844P	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	2834:2838	Mutation substituting flanking lysine	0.2778
p.V1355M	SIDM00652	Small Cell Lung Carcinoma	GDSC	VDETPSPT	DEG_SCF_FBW7_1	1353:1360	Mutation altering degron motif	0.7208
p.V2603F	SIDM00660	Colorectal Carcinoma	GDSC	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.1667
p.G2826S	SIDM00190	Melanoma	GDSC	VPTTT	DEG_SPOP_SBC_1	2834:2838	Mutation rewiring degron network	0.1111
p.V3038M	SIDM00813	Non-Cancerous	GDSC	DEAETTQAVPTM	DEG_COP1_1	3042:3053	Mutation rewiring degron network	0.2222
p.V3038M	SIDM01101	Neuroblastoma	GDSC	DEAETTQAVPTM	DEG_COP1_1	3042:3053	Mutation rewiring degron network	0.2222
p.V2518M	SIDM01073	Other Blood Cancers	GDSC	VDETPSPT	DEG_SCF_FBW7_1	2503:2510	Mutation rewiring degron network	0.1111
p.G2607S	SIDM01729	Endometrial Carcinoma	GDSC	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.2778
p.R2626H	SIDM01618	B-Lymphoblastic Leukemia	GDSC	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.1944
p.S3654A	ACH-000086	Lung Cancer	CCLE	SRPRLSQLS	DEG_APCC_DBOX_1	3654:3662	Mutation altering degron motif	0.7588
p.S3654A	ACH-000110	Gastric Cancer	CCLE	SRPRLSQLS	DEG_APCC_DBOX_1	3654:3662	Mutation altering degron motif	0.7588
p.S3654A	ACH-000205	Pancreatic Cancer	CCLE	SRPRLSQLS	DEG_APCC_DBOX_1	3654:3662	Mutation altering degron motif	0.7588
p.S3654A	ACH-000397	Endometrial/Uterine Cancer	CCLE	SRPRLSQLS	DEG_APCC_DBOX_1	3654:3662	Mutation altering degron motif	0.7588
p.S3654A	ACH-000478	Liver Cancer	CCLE	SRPRLSQLS	DEG_APCC_DBOX_1	3654:3662	Mutation altering degron motif	0.7588
p.S3654A	ACH-000526	Non-Cancerous	CCLE	SRPRLSQLS	DEG_APCC_DBOX_1	3654:3662	Mutation altering degron motif	0.7588
p.S3654A	ACH-000701	Ovarian Cancer	CCLE	SRPRLSQLS	DEG_APCC_DBOX_1	3654:3662	Mutation altering degron motif	0.7588
p.T2837K	ACH-000433	Kidney Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	2834:2838	Mutation altering degron motif	0.7306
p.T2837K	CAKI-1	kidney	COSMIC	VPTTT	DEG_SPOP_SBC_1	2834:2838	Mutation altering degron motif	0.7306
p.V2605L	ACH-000640	Skin Cancer	CCLE	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.2222
p.V2605L	SK-MEL-31	skin	COSMIC	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.2222
p.A2516V	ACH-000817	Myeloma	CCLE	VDETPSPT	DEG_SCF_FBW7_1	2503:2510	Mutation rewiring degron network	0.1667
p.A2516V	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	VDETPSPT	DEG_SCF_FBW7_1	2503:2510	Mutation rewiring degron network	0.1667
p.P2625S	ACH-000823	Esophageal Cancer	CCLE	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.2222
p.P2625S	KYSE-140	oesophagus	COSMIC	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation rewiring degron network	0.2222
p.A2612V	ACH-000988	Endometrial/Uterine Cancer	CCLE	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation altering degron motif	0.5825
p.A2612V	MFE-319	endometrium	COSMIC	EDEAETTQAVPTM	DEG_COP1_1	2609:2621	Mutation altering degron motif	0.5825
p.T3047N	ACH-000999	Colon/Colorectal Cancer	CCLE	DEAETTQAVPTM	DEG_COP1_1	3042:3053	Mutation altering degron motif	0.5944
p.T3047N	SNU-1040	large intestine	COSMIC	DEAETTQAVPTM	DEG_COP1_1	3042:3053	Mutation altering degron motif	0.5944
p.A3034V	ACH-001081	Colon/Colorectal Cancer	CCLE	DEAETTQAVPTM	DEG_COP1_1	3042:3053	Mutation rewiring degron network	0.1111
p.A3034V	HCC2998	large intestine	COSMIC	DEAETTQAVPTM	DEG_COP1_1	3042:3053	Mutation rewiring degron network	0.1111
p.P2509H	ACH-001369	Ovarian Cancer	CCLE	VDETPSPT	DEG_SCF_FBW7_1	2503:2510	Mutation altering degron motif	0.6583
p.S3033F	ACH-002253	Lymphoma	CCLE	DEAETTQAVPTM	DEG_COP1_1	3042:3053	Mutation rewiring degron network	0.0833
p.S3033F	JSC-1	haematopoietic and lymphoid tissue	COSMIC	DEAETTQAVPTM	DEG_COP1_1	3042:3053	Mutation rewiring degron network	0.0833
p.R1350H	TOV-21G	ovary	COSMIC	VDETPSPT	DEG_SCF_FBW7_1	1353:1360	Mutation rewiring degron network	0.25
p.K3041N	H513	pleura	COSMIC	DEAETTQAVPTM	DEG_COP1_1	3042:3053	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNXB

UniProt ID: P22105

Entrez ID: 7148

Protein name: Tenascin-X (TN-X) (Hexabrachion-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TNXB in