DegronMD

Uniprot ID: P22105

Source protein: Tenascin-X

Source gene: TNXB

Class: DEG_SCF_FBW7_1

Location: 1353:1360

E3 ligase: FBXW7

DEGRON score: 0.8829

ASA_SCORE: 76.4875

COIL: 0.8538

CONS_SCORE: 0.3227

DSS_SCORE: 0.8391

HELIX: 0.0494

FCONS_SCORE: 0.9582

RIG_SCORE: 0.6359

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1355M	SIDM00652	Small Cell Lung Carcinoma	GDSC	VDETPSPT	DEG_SCF_FBW7_1	0.7208
p.P1357S	DO222662	MELA	ICGC	VDETPSPT	DEG_SCF_FBW7_1	0.6752
p.E1355K	DO51282	SKCM	ICGC	VDETPSPT	DEG_SCF_FBW7_1	0.591
p.D1354N	DO9346	COAD	ICGC	VDETPSPT	DEG_SCF_FBW7_1	0.5821
p.D1354N	ACH-000561	Esophageal Cancer	CCLE	VDETPSPT	DEG_SCF_FBW7_1	0.5821
p.D1354N	T-T	oesophagus	COSMIC	VDETPSPT	DEG_SCF_FBW7_1	0.5821
p.E1361K	DO51282	SKCM	ICGC	VDETPSPT	DEG_SCF_FBW7_1	0.3056
p.S1361L	SIDM00321	Ovarian Carcinoma	GDSC	VDETPSPT	DEG_SCF_FBW7_1	0.3056
p.G1363D	DO227504	LAML	ICGC	VDETPSPT	DEG_SCF_FBW7_1	0.25
p.R1350H	TOV-21G	ovary	COSMIC	VDETPSPT	DEG_SCF_FBW7_1	0.25
p.T1364M	DO233944	GACA	ICGC	VDETPSPT	DEG_SCF_FBW7_1	0.2222
p.P1367S	DO49050	HNSC	ICGC	VDETPSPT	DEG_SCF_FBW7_1	0.1389
p.P1370H	DO26886	LUSC	ICGC	VDETPSPT	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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DegronMD: protein-targeted degradation, mutation and drug response to degrons