DegronMD

Uniprot ID: P22105

Source protein: Tenascin-X

Source gene: TNXB

Class: DEG_SCF_FBW7_1

Location: 2503:2510

E3 ligase: FBXW7

DEGRON score: 0.9022

ASA_SCORE: 80.7625

COIL: 0.9033

CONS_SCORE: 0.2045

DSS_SCORE: 0.886

HELIX: 0.0445

FCONS_SCORE: 1.0066

RIG_SCORE: 0.6099

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2508N	TCGA-66-2767	LUSC	TCGA	VDETPSPT	DEG_SCF_FBW7_1	0.5958
p.S2508N	DO26713	LUSC	ICGC	VDETPSPT	DEG_SCF_FBW7_1	0.5958
p.E2501K	TCGA-HD-8224	HNSC	TCGA	VDETPSPT	DEG_SCF_FBW7_1	0.2778
p.E2501K	DO15935	HNSC	ICGC	VDETPSPT	DEG_SCF_FBW7_1	0.2778
p.E2501K	ACH-002309	Sarcoma	CCLE	VDETPSPT	DEG_SCF_FBW7_1	0.2778
p.E2501K	SW684	soft_tissue	COSMIC	VDETPSPT	DEG_SCF_FBW7_1	0.2778
p.E2511K	TCGA-OD-A75X	SKCM	TCGA	VDETPSPT	DEG_SCF_FBW7_1	0.3056
p.E2511K	DO48601	SKCM	ICGC	VDETPSPT	DEG_SCF_FBW7_1	0.3056
p.G2495S	DO229505	LAML	ICGC	VDETPSPT	DEG_SCF_FBW7_1	0.1111
p.G2495S	DO230556	LUSC	ICGC	VDETPSPT	DEG_SCF_FBW7_1	0.1111
p.G2495S	DO231102	LUSC	ICGC	VDETPSPT	DEG_SCF_FBW7_1	0.1111
p.P2519L	DO220855	MELA	ICGC	VDETPSPT	DEG_SCF_FBW7_1	0.0833
p.E2515G	DO229224	THCA	ICGC	VDETPSPT	DEG_SCF_FBW7_1	0.1944
p.V2518M	SIDM01073	Other Blood Cancers	GDSC	VDETPSPT	DEG_SCF_FBW7_1	0.1111
p.A2516V	ACH-000817	Myeloma	CCLE	VDETPSPT	DEG_SCF_FBW7_1	0.1667
p.A2516V	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	VDETPSPT	DEG_SCF_FBW7_1	0.1667
p.P2509H	ACH-001369	Ovarian Cancer	CCLE	VDETPSPT	DEG_SCF_FBW7_1	0.6583

DegronMD: protein-targeted degradation, mutation and drug response to degrons