DegronMD

Uniprot ID: P22105

Source protein: Tenascin-X

Source gene: TNXB

Class: DEG_COP1_1

Location: 3042:3053

E3 ligase: COP1

DEGRON score: 0.6948

ASA_SCORE: 84.2583

COIL: 0.6873

CONS_SCORE: 0.2917

DSS_SCORE: 0.6777

HELIX: 0.1141

FCONS_SCORE: 0.6836

RIG_SCORE: 0.7121

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3036A	TCGA-AX-A2HC	UCEC	TCGA	DEAETTQAVPTM	DEG_COP1_1	0.1667
p.P3051H	DO550	BLCA	ICGC	DEAETTQAVPTM	DEG_COP1_1	0.7694
p.L3063Q	DO50828	LICA	ICGC	DEAETTQAVPTM	DEG_COP1_1	0.0556
p.S3033P	DO22802	LICA	ICGC	DEAETTQAVPTM	DEG_COP1_1	0.0833
p.R3062H	DO36305	PRAD	ICGC	DEAETTQAVPTM	DEG_COP1_1	0.0833
p.E3041K	DO38123	SKCM	ICGC	DEAETTQAVPTM	DEG_COP1_1	0.3056
p.T3052I	DO43186	UCEC	ICGC	DEAETTQAVPTM	DEG_COP1_1	0.7078
p.T3038A	DO41572	UCEC	ICGC	DEAETTQAVPTM	DEG_COP1_1	0.2222
p.R3062C	DO41488	UCEC	ICGC	DEAETTQAVPTM	DEG_COP1_1	0.0833
p.R3045H	SIDM01104	Melanoma	GDSC	DEAETTQAVPTM	DEG_COP1_1	0.8244
p.V3038M	SIDM00813	Non-Cancerous	GDSC	DEAETTQAVPTM	DEG_COP1_1	0.2222
p.V3038M	SIDM01101	Neuroblastoma	GDSC	DEAETTQAVPTM	DEG_COP1_1	0.2222
p.T3047N	ACH-000999	Colon/Colorectal Cancer	CCLE	DEAETTQAVPTM	DEG_COP1_1	0.5944
p.T3047N	SNU-1040	large_intestine	COSMIC	DEAETTQAVPTM	DEG_COP1_1	0.5944
p.A3034V	ACH-001081	Colon/Colorectal Cancer	CCLE	DEAETTQAVPTM	DEG_COP1_1	0.1111
p.A3034V	HCC2998	large_intestine	COSMIC	DEAETTQAVPTM	DEG_COP1_1	0.1111
p.S3033F	ACH-002253	Lymphoma	CCLE	DEAETTQAVPTM	DEG_COP1_1	0.0833
p.S3033F	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	DEAETTQAVPTM	DEG_COP1_1	0.0833
p.K3041N	H513	pleura	COSMIC	DEAETTQAVPTM	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22105	Tenascin-X	DEG_COP1_1	3042:3053	DEAETTQAVPTM	COP1	0.6948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons