DegronMD

Uniprot ID: P22105

Source protein: Tenascin-X

Source gene: TNXB

Class: DEG_COP1_1

Location: 2609:2621

E3 ligase: COP1

DEGRON score: 0.5492

ASA_SCORE: 91.7615

COIL: 0.7618

CONS_SCORE: 0.3479

DSS_SCORE: 0.6776

HELIX: 0.0816

FCONS_SCORE: 1.0178

RIG_SCORE: 0.7211

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T2614S	TCGA-05-4390	LUAD	TCGA	EDEAETTQAVPTM	DEG_COP1_1	0.6005
p.T2614S	DO23562	LUAD	ICGC	EDEAETTQAVPTM	DEG_COP1_1	0.6005
p.P2629A	TCGA-AA-3502	COAD	TCGA	EDEAETTQAVPTM	DEG_COP1_1	0.1111
p.P2629A	DO7775	COAD	ICGC	EDEAETTQAVPTM	DEG_COP1_1	0.1111
p.A2604V	TCGA-AJ-A2QO	UCEC	TCGA	EDEAETTQAVPTM	DEG_COP1_1	0.1944
p.A2604V	DO229234	THCA	ICGC	EDEAETTQAVPTM	DEG_COP1_1	0.1944
p.A2604V	DO229245	THCA	ICGC	EDEAETTQAVPTM	DEG_COP1_1	0.1944
p.A2604V	DO42177	UCEC	ICGC	EDEAETTQAVPTM	DEG_COP1_1	0.1944
p.T2620I	TCGA-EB-A3XF	SKCM	TCGA	EDEAETTQAVPTM	DEG_COP1_1	0.7078
p.T2620I	DO37437	SKCM	ICGC	EDEAETTQAVPTM	DEG_COP1_1	0.7078
p.P2623L	TCGA-FR-A726	SKCM	TCGA	EDEAETTQAVPTM	DEG_COP1_1	0.2778
p.P2623L	DO48665	SKCM	ICGC	EDEAETTQAVPTM	DEG_COP1_1	0.2778
p.R2630C	TCGA-GN-A269	SKCM	TCGA	EDEAETTQAVPTM	DEG_COP1_1	0.0833
p.R2630C	DO37483	SKCM	ICGC	EDEAETTQAVPTM	DEG_COP1_1	0.0833
p.D2610Y	TCGA-L5-A88S	ESCA	TCGA	EDEAETTQAVPTM	DEG_COP1_1	0.7325
p.R2630H	TCGA-WE-AAA3	SKCM	TCGA	EDEAETTQAVPTM	DEG_COP1_1	0.0833
p.R2630H	DO51295	SKCM	ICGC	EDEAETTQAVPTM	DEG_COP1_1	0.0833
p.L2599V	DO23210	LINC	ICGC	EDEAETTQAVPTM	DEG_COP1_1	0.0556
p.V2603F	SIDM00660	Colorectal Carcinoma	GDSC	EDEAETTQAVPTM	DEG_COP1_1	0.1667
p.G2607S	SIDM01729	Endometrial Carcinoma	GDSC	EDEAETTQAVPTM	DEG_COP1_1	0.2778
p.R2626H	SIDM01618	B-Lymphoblastic Leukemia	GDSC	EDEAETTQAVPTM	DEG_COP1_1	0.1944
p.V2605L	ACH-000640	Skin Cancer	CCLE	EDEAETTQAVPTM	DEG_COP1_1	0.2222
p.V2605L	SK-MEL-31	skin	COSMIC	EDEAETTQAVPTM	DEG_COP1_1	0.2222
p.P2625S	ACH-000823	Esophageal Cancer	CCLE	EDEAETTQAVPTM	DEG_COP1_1	0.2222
p.P2625S	KYSE-140	oesophagus	COSMIC	EDEAETTQAVPTM	DEG_COP1_1	0.2222
p.A2612V	ACH-000988	Endometrial/Uterine Cancer	CCLE	EDEAETTQAVPTM	DEG_COP1_1	0.5825
p.A2612V	MFE-319	endometrium	COSMIC	EDEAETTQAVPTM	DEG_COP1_1	0.5825

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EDEAETTQAVPTM

Degron related mutations and impact score

Drug responses associated with TNXB mutations

All proteins holding degron of EDEAETTQAVPTM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22105	Tenascin-X	DEG_COP1_1	2609:2621	EDEAETTQAVPTM	COP1	0.5492	More...