DegronMD

Uniprot ID: P22105

Source protein: Tenascin-X

Source gene: TNXB

Class: DEG_APCC_DBOX_1

Location: 3654:3662

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9916

ASA_SCORE: 73.7778

COIL: 0.6157

CONS_SCORE: 0.4719

DSS_SCORE: 0.5651

HELIX: 0.1658

FCONS_SCORE: 1.2655

RIG_SCORE: 0.7036

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3654A	ACH-000086	Lung Cancer	CCLE	SRPRLSQLS	DEG_APCC_DBOX_1	0.7588
p.S3654A	ACH-000110	Gastric Cancer	CCLE	SRPRLSQLS	DEG_APCC_DBOX_1	0.7588
p.S3654A	ACH-000205	Pancreatic Cancer	CCLE	SRPRLSQLS	DEG_APCC_DBOX_1	0.7588
p.S3654A	ACH-000397	Endometrial/Uterine Cancer	CCLE	SRPRLSQLS	DEG_APCC_DBOX_1	0.7588
p.S3654A	ACH-000478	Liver Cancer	CCLE	SRPRLSQLS	DEG_APCC_DBOX_1	0.7588
p.S3654A	ACH-000526	Non-Cancerous	CCLE	SRPRLSQLS	DEG_APCC_DBOX_1	0.7588
p.S3654A	ACH-000701	Ovarian Cancer	CCLE	SRPRLSQLS	DEG_APCC_DBOX_1	0.7588

DegronMD: protein-targeted degradation, mutation and drug response to degrons