DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SRPRLSQLS
Uniprot ID:
Q16473
Source protein:
Putative tenascin-XA
Source gene:
TNXA
Class:
DEG_APCC_DBOX_1
Location:
142:150
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8944
ASA_SCORE:
66.9778
COIL:
0.5976
CONS_SCORE:
0
DSS_SCORE:
0.5651
HELIX:
0.053
FCONS_SCORE:
0
RIG_SCORE:
0.7036
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with TNXA mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SRPRLSQLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P22105
Tenascin-X
DEG_APCC_DBOX_1
3654:3662
SRPRLSQLS
APC,CDC20,FZR1
0.9916
More...
Q16473
Putative tenascin-XA
DEG_APCC_DBOX_1
142:150
SRPRLSQLS
APC,CDC20,FZR1
0.8944
More...