DegronMD

Uniprot ID: O94880

Source protein: PHD finger protein 14

Source gene: PHF14

Class: DEG_SPOP_SBC_1

Location: 166:170

E3 ligase: SPOP

DEGRON score: 0.991

ASA_SCORE: 87.56

COIL: 0.954

CONS_SCORE: 0.303

DSS_SCORE: 0.6763

HELIX: 0.0204

FCONS_SCORE: 1.0124

RIG_SCORE: 0.6537

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P180L	TCGA-29-1691	OV	TCGA	VPTTT	DEG_SPOP_SBC_1	0.0556
p.P180L	DO32133	OV	ICGC	VPTTT	DEG_SPOP_SBC_1	0.0556
p.A172T	TCGA-AP-A051	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.2778
p.A172T	TCGA-D1-A103	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.2778
p.A172T	DO42312	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2778
p.A172T	DO42673	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2778
p.E179K	TCGA-EO-A3AV	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	0.0833
p.E179K	DO222762	COCA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.0833
p.E179K	DO52412	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.0833
p.S165F	TCGA-VR-A8EX	ESCA	TCGA	VPTTT	DEG_SPOP_SBC_1	0.3056
p.D174V	DO7798	COAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2222
p.T169M	DO222794	COCA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7423
p.T169M	DO222842	COCA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7423
p.D174Y	DO234303	ESAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2222
p.S178G	DO223053	ESCA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1111
p.V169F	DO44448	HNSC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7068
p.C178F	DO228976	LICA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1111
p.S172I	DO229029	LICA	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2778
p.R163C	DO25622	LUAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.6944
p.R163C	DO37406	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	0.6944
p.R163C	DO223286	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.6944
p.C173F	DO23744	LUAD	ICGC	VPTTT	DEG_SPOP_SBC_1	0.25
p.S172R	DO36556	READ	ICGC	VPTTT	DEG_SPOP_SBC_1	0.2778
p.G168W	DO51236	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7825
p.C178Y	DO52424	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.1111
p.R163H	DO42608	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.6944
p.T167A	DO41235	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	0.7139
p.A159V	SIDM00516	Melanoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.1389
p.A159V	ACH-002166	Skin Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	0.1389
p.A159V	MZ7-mel	skin	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.1389
p.S163F	SIDM00852	Glioma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.6944
p.S163F	H4	central_nervous_system	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.6944
p.V166L	SIDM00220	Ovarian Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	0.6765
p.V166L	ACH-000962	Ovarian Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	0.6765
p.V166L	ACH-001145	Ovarian Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	0.6765
p.V166L	OC-314	ovary	COSMIC	VPTTT	DEG_SPOP_SBC_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75829	Leukocyte cell-derived chemotaxin 1	DEG_SPOP_SBC_1	221:225	VPTTT	SPOP	0.9724	More...
P22105	Tenascin-X	DEG_SPOP_SBC_1	2834:2838	VPTTT	SPOP	0.8867	More...
P98171	Rho GTPase-activating protein 4	DEG_SPOP_SBC_1	200:204	VPTTT	SPOP	0.9213	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5806:5810	VPTTT	SPOP	0.9863	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11618:11622	VPTTT	SPOP	0.7076	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	150:154	VPTTT	SPOP	0.9885	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	161:165	VPTTT	SPOP	0.986	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	190:194	VPTTT	SPOP	0.9092	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2051:2055	VPTTT	SPOP	0.9951	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3308:3312	VPTTT	SPOP	0.993	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3865:3869	VPTTT	SPOP	0.9882	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4593:4597	VPTTT	SPOP	0.9609	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SPOP_SBC_1	625:629	VPTTT	SPOP	0.8307	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	543:547	VPTTT	SPOP	0.7751	More...
O94880	PHD finger protein 14	DEG_SPOP_SBC_1	166:170	VPTTT	SPOP	0.991	More...
Q8WW62	Transmembrane emp24 domain-containing protein 6	DEG_SPOP_SBC_1	229:233	VPTTT	SPOP	0.7106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPTTT

Degron related mutations and impact score

Drug responses associated with PHF14 mutations

All proteins holding degron of VPTTT