DegronMD - P98171(ARHGAP4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G211R	TCGA-55-7281	LUAD	TCGA	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1389
p.R214C	TCGA-77-A5GH	LUSC	TCGA	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.0556
p.R214C	TCGA-KN-8428	KICH	TCGA	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.0556
p.S900P	TCGA-AJ-A8CW	UCEC	TCGA	PASTT	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.2778
p.V905M	TCGA-B5-A3FC	UCEC	TCGA	PASTT	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.1389
p.S199I	TCGA-D1-A103	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation blocking phosphorylation signal	0.75
p.M886I	TCGA-EE-A2M7	SKCM	TCGA	PASTT	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.1111
p.M886I	DO37847	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.1111
p.A205S	TCGA-EL-A4K7	THCA	TCGA	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.3056
p.P888S	TCGA-FW-A3R5	SKCM	TCGA	PASTT	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.1667
p.E192K	TCGA-WE-A8K4	SKCM	TCGA	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1111
p.R884Q	DO225168	BRCA	ICGC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.0556
p.R884Q	DO223732	CESC	ICGC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.0556
p.R893H	DO228483	BRCA	ICGC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.3056
p.R893H	DO50157	LGG	ICGC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.3056
p.R893H	8-MG-BA	central nervous system	COSMIC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.3056
p.R893H	KP-N-YN	autonomic ganglia	COSMIC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.3056
p.R893H	JHOS-2	ovary	COSMIC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.3056
p.R193C	DO220484	KICH	ICGC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1389
p.R193C	DO45452	LUSC	ICGC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1389
p.G190R	DO25985	LUAD	ICGC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.0556
p.G905W	DO37413	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.1389
p.S196F	DO47389	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2222
p.R896M	DO47374	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation altering degron motif	0.8632
p.R207L	DO37946	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.25
p.L197I	DO38075	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.25
p.G887R	DO41199	UCEC	ICGC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation blocking phosphorylation signal	0.5833
p.R214H	SIDM00680	Colorectal Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.0556
p.R214H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.0556
p.R214H	SIDM00220	Ovarian Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.0556
p.R214H	ACH-000957	Colon/Colorectal Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.0556
p.R214H	ACH-000962	Ovarian Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.0556
p.R214H	ACH-001145	Ovarian Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.0556
p.R214H	OC-314	ovary	COSMIC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.0556
p.R214H	LS-180	large intestine	COSMIC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.0556
p.P201S	SIDM00861	Ovarian Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.5641
p.P201S	ACH-000906	Ovarian Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.5641
p.P201S	ES-2	ovary	COSMIC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.5641
p.V897D	SIDM00016	Neuroblastoma	GDSC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation altering degron motif	0.7785
p.R193H	LS-180	large intestine	COSMIC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1389
p.R193H	OC-314	ovary	COSMIC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1389
p.S901F	NCI-H810	lung	COSMIC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation blocking phosphorylation signal	0.6944
p.K898T	RCC-JW	kidney	COSMIC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation altering degron motif	0.7306
p.S199R	BPH-1	prostate	COSMIC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation blocking phosphorylation signal	0.75

Kaplan plot for ARHGAP4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP4

UniProt ID: P98171

Entrez ID: 393

Protein name: Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGAP4 in