DegronMD - P98171(ARHGAP4)

FUNCTION: Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.

GO - Biological processes (BP): cytoskeleton organization [GO:0007010]; negative regulation of axon extension [GO:0030517]; negative regulation of cell migration [GO:0030336]; negative regulation of fibroblast migration [GO:0010764]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduct... View more >>

GO - Molecular function (MF): GTPase activator activity [GO:0005096]; identical protein binding [GO:0042802]

GO - Cellular component (CC): cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
VPTTT	DEG_SPOP_SBC_1	SPOP	Rho GTPase-activating protein 4	200:204	More..
PASTT	DEG_SPOP_SBC_1	SPOP	Rho GTPase-activating protein 4	894:898	More..

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Mutation	Sample	Cancer	Degron hit	Class	Location	Dataset
p.P201S	ACH-000906	Ovarian Cancer	VPTTT	DEG_SPOP_SBC_1	200:204	CCLE
p.R214H	ACH-000957	Colon/Colorectal Cancer	VPTTT	DEG_SPOP_SBC_1	200:204	CCLE
p.R214H	ACH-000962	Ovarian Cancer	VPTTT	DEG_SPOP_SBC_1	200:204	CCLE
p.R214H	ACH-001145	Ovarian Cancer	VPTTT	DEG_SPOP_SBC_1	200:204	CCLE
p.S199R	BPH-1	prostate	VPTTT	DEG_SPOP_SBC_1	200:204	COSMIC
p.P201S	ES-2	ovary	VPTTT	DEG_SPOP_SBC_1	200:204	COSMIC
p.R214H	LS-180	large_intestine	VPTTT	DEG_SPOP_SBC_1	200:204	COSMIC
p.S901F	NCI-H810	lung	PASTT	DEG_SPOP_SBC_1	894:898	COSMIC
p.R214H	OC-314	ovary	VPTTT	DEG_SPOP_SBC_1	200:204	COSMIC
p.R214H	SIDM00220	Ovarian Carcinoma	VPTTT	DEG_SPOP_SBC_1	200:204	GDSC

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R896M	DO47374	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation altering degron motif	0.8632
p.V897D	SIDM00016	Neuroblastoma	GDSC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation altering degron motif	0.7785
p.S199I	TCGA-D1-A103	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation blocking phosphorylation signal	0.75
p.S199R	BPH-1	prostate	COSMIC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation blocking phosphorylation signal	0.75
p.K898T	RCC-JW	kidney	COSMIC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation altering degron motif	0.7306
p.S901F	NCI-H810	lung	COSMIC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation blocking phosphorylation signal	0.6944
p.G887R	DO41199	UCEC	ICGC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation blocking phosphorylation signal	0.5833
p.P201S	SIDM00861	Ovarian Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.5641
p.P201S	ACH-000906	Ovarian Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.5641
p.P201S	ES-2	ovary	COSMIC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.5641
p.A205S	TCGA-EL-A4K7	THCA	TCGA	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.3056
p.R893H	DO228483	BRCA	ICGC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.3056
p.R893H	DO50157	LGG	ICGC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.3056
p.R893H	8-MG-BA	central nervous system	COSMIC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.3056
p.R893H	KP-N-YN	autonomic ganglia	COSMIC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.3056
p.R893H	JHOS-2	ovary	COSMIC	PASTT	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.3056
p.S900P	TCGA-AJ-A8CW	UCEC	TCGA	PASTT	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.2778
p.R207L	DO37946	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.25
p.L197I	DO38075	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.25
p.S196F	DO47389	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2222

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No drug screening data available for this protein.

No resistance data available for this Degron.

Kaplan plot for ARHGAP4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP4

UniProt ID: P98171

Entrez ID: 393

Protein name: Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115)

External links: UniprotKB HGNC RefSeq COSMIC

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No drug screening data available for this protein.

No resistance data available for this Degron.

Kaplan plot for ARHGAP4 in