DegronMD

Uniprot ID: P98171

Source protein: Rho GTPase-activating protein 4

Source gene: ARHGAP4

Class: DEG_SPOP_SBC_1

Location: 894:898

E3 ligase: SPOP

DEGRON score: 0.9571

ASA_SCORE: 84.78

COIL: 0.8918

CONS_SCORE: 0.2958

DSS_SCORE: 0.7638

HELIX: 0.0944

FCONS_SCORE: 1.0072

RIG_SCORE: 0.5486

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S900P	TCGA-AJ-A8CW	UCEC	TCGA	PASTT	DEG_SPOP_SBC_1	0.2778
p.V905M	TCGA-B5-A3FC	UCEC	TCGA	PASTT	DEG_SPOP_SBC_1	0.1389
p.M886I	TCGA-EE-A2M7	SKCM	TCGA	PASTT	DEG_SPOP_SBC_1	0.1111
p.M886I	DO37847	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	0.1111
p.P888S	TCGA-FW-A3R5	SKCM	TCGA	PASTT	DEG_SPOP_SBC_1	0.1667
p.R884Q	DO225168	BRCA	ICGC	PASTT	DEG_SPOP_SBC_1	0.0556
p.R884Q	DO223732	CESC	ICGC	PASTT	DEG_SPOP_SBC_1	0.0556
p.R893H	DO228483	BRCA	ICGC	PASTT	DEG_SPOP_SBC_1	0.3056
p.R893H	DO50157	LGG	ICGC	PASTT	DEG_SPOP_SBC_1	0.3056
p.R893H	8-MG-BA	central_nervous_system	COSMIC	PASTT	DEG_SPOP_SBC_1	0.3056
p.R893H	KP-N-YN	autonomic_ganglia	COSMIC	PASTT	DEG_SPOP_SBC_1	0.3056
p.R893H	JHOS-2	ovary	COSMIC	PASTT	DEG_SPOP_SBC_1	0.3056
p.G905W	DO37413	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	0.1389
p.R896M	DO47374	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	0.8632
p.G887R	DO41199	UCEC	ICGC	PASTT	DEG_SPOP_SBC_1	0.5833
p.V897D	SIDM00016	Neuroblastoma	GDSC	PASTT	DEG_SPOP_SBC_1	0.7785
p.S901F	NCI-H810	lung	COSMIC	PASTT	DEG_SPOP_SBC_1	0.6944
p.K898T	RCC-JW	kidney	COSMIC	PASTT	DEG_SPOP_SBC_1	0.7306

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	983:987	PASTT	SPOP	0.9313	More...
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	988:992	PASTT	SPOP	0.889	More...
P11161	E3 SUMO-protein ligase EGR2	DEG_SPOP_SBC_1	127:131	PASTT	SPOP	0.9571	More...
P20810	Calpastatin	DEG_SPOP_SBC_1	547:551	PASTT	SPOP	0.9976	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	93:97	PASTT	SPOP	0.9667	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2297:2301	PASTT	SPOP	0.6997	More...
P98171	Rho GTPase-activating protein 4	DEG_SPOP_SBC_1	894:898	PASTT	SPOP	0.9571	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1511:1515	PASTT	SPOP	0.6572	More...
Q08999	Retinoblastoma-like protein 2	DEG_SPOP_SBC_1	674:678	PASTT	SPOP	0.9981	More...
Q5THR3	EF-hand calcium-binding domain-containing protein 6	DEG_SPOP_SBC_1	1295:1299	PASTT	SPOP	0.9774	More...
Q6BAA4	Fc receptor-like B	DEG_SPOP_SBC_1	294:298	PASTT	SPOP	0.9844	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	358:362	PASTT	SPOP	0.974	More...
Q99607	ETS-related transcription factor Elf-4	DEG_SPOP_SBC_1	433:437	PASTT	SPOP	0.7975	More...
Q9BR76	Coronin-1B	DEG_SPOP_SBC_1	429:433	PASTT	SPOP	0.9688	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1644:1648	PASTT	SPOP	0.9635	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4925:4929	PASTT	SPOP	0.9738	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4981:4985	PASTT	SPOP	0.7062	More...
Q9Y692	Glucocorticoid modulatory element-binding protein 1	DEG_SPOP_SBC_1	385:389	PASTT	SPOP	0.947	More...
A6NMD0	Interferon-induced transmembrane protein 10	DEG_SPOP_SBC_1	42:46	PASTT	SPOP	0.9896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PASTT

Degron related mutations and impact score

Drug responses associated with ARHGAP4 mutations

All proteins holding degron of PASTT