DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PASTT
Uniprot ID:
O75151
Source protein:
Lysine-specific demethylase PHF2
Source gene:
PHF2
Class:
DEG_SPOP_SBC_1
Location:
983:987
E3 ligase:
SPOP
DEGRON score:
0.9313
ASA_SCORE:
89.32
COIL:
0.9662
CONS_SCORE:
0.2044
DSS_SCORE:
0.6675
HELIX:
0.0148
FCONS_SCORE:
1.0086
RIG_SCORE:
0.6015
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PHF2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PASTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75151
Lysine-specific demethylase PHF2
DEG_SPOP_SBC_1
983:987
PASTT
SPOP
0.9313
More...
O75151
Lysine-specific demethylase PHF2
DEG_SPOP_SBC_1
988:992
PASTT
SPOP
0.889
More...
P11161
E3 SUMO-protein ligase EGR2
DEG_SPOP_SBC_1
127:131
PASTT
SPOP
0.9571
More...
P20810
Calpastatin
DEG_SPOP_SBC_1
547:551
PASTT
SPOP
0.9976
More...
P54727
UV excision repair protein RAD23 homolog B
DEG_SPOP_SBC_1
93:97
PASTT
SPOP
0.9667
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
2297:2301
PASTT
SPOP
0.6997
More...
P98171
Rho GTPase-activating protein 4
DEG_SPOP_SBC_1
894:898
PASTT
SPOP
0.9571
More...
Q02817
Mucin-2
DEG_SPOP_SBC_1
1511:1515
PASTT
SPOP
0.6572
More...
Q08999
Retinoblastoma-like protein 2
DEG_SPOP_SBC_1
674:678
PASTT
SPOP
0.9981
More...
Q5THR3
EF-hand calcium-binding domain-containing protein 6
DEG_SPOP_SBC_1
1295:1299
PASTT
SPOP
0.9774
More...
Q6BAA4
Fc receptor-like B
DEG_SPOP_SBC_1
294:298
PASTT
SPOP
0.9844
More...
Q92954
Proteoglycan 4
DEG_SPOP_SBC_1
358:362
PASTT
SPOP
0.974
More...
Q99607
ETS-related transcription factor Elf-4
DEG_SPOP_SBC_1
433:437
PASTT
SPOP
0.7975
More...
Q9BR76
Coronin-1B
DEG_SPOP_SBC_1
429:433
PASTT
SPOP
0.9688
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
1644:1648
PASTT
SPOP
0.9635
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
4925:4929
PASTT
SPOP
0.9738
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
4981:4985
PASTT
SPOP
0.7062
More...
Q9Y692
Glucocorticoid modulatory element-binding protein 1
DEG_SPOP_SBC_1
385:389
PASTT
SPOP
0.947
More...
A6NMD0
Interferon-induced transmembrane protein 10
DEG_SPOP_SBC_1
42:46
PASTT
SPOP
0.9896
More...