DegronMD - Q6BAA4(FCRLB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P291L	TCGA-55-8097	LUAD	TCGA	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.P291L	DO25699	LUAD	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.S296C	TCGA-CN-5358	HNSC	TCGA	PASTT	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.7541
p.S296C	DO14878	HNSC	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.7541
p.P302T	TCGA-CV-5976	HNSC	TCGA	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.2222
p.P302T	DO15751	HNSC	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.2222
p.A413T	TCGA-DD-A4NQ	LIHC	TCGA	PGTPETT	DEG_SCF_FBW7_1	416:422	Mutation rewiring degron network	0.25
p.A413T	DO44887	LIHC	ICGC	PGTPETT	DEG_SCF_FBW7_1	416:422	Mutation rewiring degron network	0.25
p.P291T	TCGA-Q1-A5R2	CESC	TCGA	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.P291T	DO49003	CESC	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.A301P	DO48442	BLCA	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.A301P	DO230334	COCA	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.A301P	DO229010	COCA	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.A301P	DO229013	COCA	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.A301P	DO229016	COCA	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.A301P	DO229003	COCA	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.A301P	DO229005	COCA	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.A301P	DO229480	LAML	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.A301P	DO231031	LUSC	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.R294Q	DO8842	COAD	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.7329
p.R301H	DO233259	GACA	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.P416L	DO233814	GACA	ICGC	PGTPETT	DEG_SCF_FBW7_1	416:422	Mutation altering degron motif	0.6471
p.R301L	DO229015	LICA	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.P419L	DO23238	LINC	ICGC	PGTPETT	DEG_SCF_FBW7_1	416:422	Mutation altering degron motif	0.7582
p.T409S	DO23332	LINC	ICGC	PGTPETT	DEG_SCF_FBW7_1	416:422	Mutation rewiring degron network	0.1389
p.P302S	DO230961	LUSC	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.2222
p.P302S	DO224594	LUSC	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.2222
p.P291H	DO233298	NACA	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.25
p.P297Q	DO37651	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.7035
p.R308Q	DO47981	STAD	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.0556
p.G287W	DO229195	THCA	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1389
p.C284Y	DO41584	UCEC	ICGC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.0556
p.E406K	SIDM00881	Breast Carcinoma	GDSC	PGTPETT	DEG_SCF_FBW7_1	416:422	Mutation rewiring degron network	0.0556
p.E406K	ACH-000352	Breast Cancer	CCLE	PGTPETT	DEG_SCF_FBW7_1	416:422	Mutation rewiring degron network	0.0556
p.E406K	HCC1428	breast	COSMIC	PGTPETT	DEG_SCF_FBW7_1	416:422	Mutation rewiring degron network	0.0556
p.T285I	LU-165	lung	COSMIC	PASTT	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FCRLB

UniProt ID: Q6BAA4

Entrez ID: 127943

Protein name: Fc receptor-like B (Fc receptor homolog expressed in B-cells protein 2) (FREB-2) (Fc receptor-like and mucin-like protein 2) (Fc receptor-like protein 2) (Fc receptor-related protein Y) (FcRY)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FCRLB in