DegronMD

Uniprot ID: Q6BAA4

Source protein: Fc receptor-like B

Source gene: FCRLB

Class: DEG_SCF_FBW7_1

Location: 416:422

E3 ligase: FBXW7

DEGRON score: 0.8345

ASA_SCORE: 82.9286

COIL: 0.8911

CONS_SCORE: 0.8237

DSS_SCORE: 0.8377

HELIX: 0.013

FCONS_SCORE: 1.2199

RIG_SCORE: 0.5896

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A413T	TCGA-DD-A4NQ	LIHC	TCGA	PGTPETT	DEG_SCF_FBW7_1	0.25
p.A413T	DO44887	LIHC	ICGC	PGTPETT	DEG_SCF_FBW7_1	0.25
p.P416L	DO233814	GACA	ICGC	PGTPETT	DEG_SCF_FBW7_1	0.6471
p.P419L	DO23238	LINC	ICGC	PGTPETT	DEG_SCF_FBW7_1	0.7582
p.T409S	DO23332	LINC	ICGC	PGTPETT	DEG_SCF_FBW7_1	0.1389
p.E406K	SIDM00881	Breast Carcinoma	GDSC	PGTPETT	DEG_SCF_FBW7_1	0.0556
p.E406K	ACH-000352	Breast Cancer	CCLE	PGTPETT	DEG_SCF_FBW7_1	0.0556
p.E406K	HCC1428	breast	COSMIC	PGTPETT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6BAA4	Fc receptor-like B	DEG_SCF_FBW7_1	416:422	PGTPETT	FBXW7	0.8345	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons