DegronMD

Uniprot ID: Q9Y692

Source protein: Glucocorticoid modulatory element-binding protein 1

Source gene: GMEB1

Class: DEG_SPOP_SBC_1

Location: 385:389

E3 ligase: SPOP

DEGRON score: 0.947

ASA_SCORE: 99.56

COIL: 0.9434

CONS_SCORE: 0.3726

DSS_SCORE: 0.7157

HELIX: 0.0202

FCONS_SCORE: 0.8316

RIG_SCORE: 0.6504

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P395S	TCGA-17-Z049	LUAD	TCGA	PASTT	DEG_SPOP_SBC_1	0.1667
p.R379W	TCGA-53-A4EZ	LUAD	TCGA	PASTT	DEG_SPOP_SBC_1	0.1667
p.R384W	TCGA-A6-6781	COAD	TCGA	PASTT	DEG_SPOP_SBC_1	0.3056
p.K375M	TCGA-AG-3896	READ	TCGA	PASTT	DEG_SPOP_SBC_1	0.1667
p.A386S	TCGA-AZ-6603	COAD	TCGA	PASTT	DEG_SPOP_SBC_1	0.6477
p.P396L	TCGA-D3-A2JF	SKCM	TCGA	PASTT	DEG_SPOP_SBC_1	0.1389
p.P396L	SIDM00936	Bladder Carcinoma	GDSC	PASTT	DEG_SPOP_SBC_1	0.1389
p.P396L	CAL-29	urinary_tract	COSMIC	PASTT	DEG_SPOP_SBC_1	0.1389
p.S394P	TCGA-RC-A7SK	LIHC	TCGA	PASTT	DEG_SPOP_SBC_1	0.1944
p.P385T	DO224847	BRCA	ICGC	PASTT	DEG_SPOP_SBC_1	0.7031
p.P385T	DO227473	BRCA	ICGC	PASTT	DEG_SPOP_SBC_1	0.7031
p.A376S	DO10188	COAD	ICGC	PASTT	DEG_SPOP_SBC_1	0.0833
p.S384P	DO52314	LIHC	ICGC	PASTT	DEG_SPOP_SBC_1	0.3056
p.P386L	DO38153	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	0.7582
p.P386L	ACH-000142	Bladder Cancer	CCLE	PASTT	DEG_SPOP_SBC_1	0.7582
p.P386L	CAL-29	urinary_tract	COSMIC	PASTT	DEG_SPOP_SBC_1	0.7582
p.P390T	DO42673	UCEC	ICGC	PASTT	DEG_SPOP_SBC_1	0.3056
p.R381Q	SIDM00217	Colorectal Carcinoma	GDSC	PASTT	DEG_SPOP_SBC_1	0.2222
p.R381Q	SIDM00220	Ovarian Carcinoma	GDSC	PASTT	DEG_SPOP_SBC_1	0.2222
p.R381Q	OC-314	ovary	COSMIC	PASTT	DEG_SPOP_SBC_1	0.2222
p.R381Q	SNU-1040	large_intestine	COSMIC	PASTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	983:987	PASTT	SPOP	0.9313	More...
O75151	Lysine-specific demethylase PHF2	DEG_SPOP_SBC_1	988:992	PASTT	SPOP	0.889	More...
P11161	E3 SUMO-protein ligase EGR2	DEG_SPOP_SBC_1	127:131	PASTT	SPOP	0.9571	More...
P20810	Calpastatin	DEG_SPOP_SBC_1	547:551	PASTT	SPOP	0.9976	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	93:97	PASTT	SPOP	0.9667	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2297:2301	PASTT	SPOP	0.6997	More...
P98171	Rho GTPase-activating protein 4	DEG_SPOP_SBC_1	894:898	PASTT	SPOP	0.9571	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1511:1515	PASTT	SPOP	0.6572	More...
Q08999	Retinoblastoma-like protein 2	DEG_SPOP_SBC_1	674:678	PASTT	SPOP	0.9981	More...
Q5THR3	EF-hand calcium-binding domain-containing protein 6	DEG_SPOP_SBC_1	1295:1299	PASTT	SPOP	0.9774	More...
Q6BAA4	Fc receptor-like B	DEG_SPOP_SBC_1	294:298	PASTT	SPOP	0.9844	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	358:362	PASTT	SPOP	0.974	More...
Q99607	ETS-related transcription factor Elf-4	DEG_SPOP_SBC_1	433:437	PASTT	SPOP	0.7975	More...
Q9BR76	Coronin-1B	DEG_SPOP_SBC_1	429:433	PASTT	SPOP	0.9688	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1644:1648	PASTT	SPOP	0.9635	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4925:4929	PASTT	SPOP	0.9738	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4981:4985	PASTT	SPOP	0.7062	More...
Q9Y692	Glucocorticoid modulatory element-binding protein 1	DEG_SPOP_SBC_1	385:389	PASTT	SPOP	0.947	More...
A6NMD0	Interferon-induced transmembrane protein 10	DEG_SPOP_SBC_1	42:46	PASTT	SPOP	0.9896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PASTT

Degron related mutations and impact score

Drug responses associated with GMEB1 mutations

All proteins holding degron of PASTT