DegronMD - P20810(CAST)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P675S	TCGA-55-A490	LUAD	TCGA	AASSS	DEG_SPOP_SBC_1	679:683	Mutation substituting flanking lysine	0.3333
p.P675S	DO24596	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	679:683	Mutation substituting flanking lysine	0.3333
p.D187Y	TCGA-62-A46O	LUAD	TCGA	PMSST	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.7325
p.E559K	TCGA-78-7539	LUAD	TCGA	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation rewiring degron network	0.0833
p.E559K	TCGA-78-7539	LUAD	TCGA	PASTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1111
p.E559K	DO26210	LUAD	ICGC	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation rewiring degron network	0.0833
p.E559K	DO26210	LUAD	ICGC	PASTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1111
p.S193L	TCGA-99-8025	LUAD	TCGA	PMSST	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2222
p.S193L	TCGA-99-8025	LUAD	TCGA	PPKY	ITCH	202:205	Mutation rewiring degron network	0.0833
p.E487D	TCGA-A5-A0GB	UCEC	TCGA	DYR	CBL_MET	480:482	Mutation substituting flanking lysine	0.3056
p.E487D	TCGA-A5-A0GB	UCEC	TCGA	PPDY	ITCH	478:481	Mutation substituting flanking lysine	0.2778
p.E487D	DO41434	UCEC	ICGC	DYR	CBL_MET	480:482	Mutation substituting flanking lysine	0.3056
p.E487D	DO41434	UCEC	ICGC	PPDY	ITCH	478:481	Mutation substituting flanking lysine	0.2778
p.A556V	TCGA-AP-A059	UCEC	TCGA	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation rewiring degron network	0.1667
p.A556V	TCGA-AP-A059	UCEC	TCGA	PASTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1944
p.A556V	DO41361	UCEC	ICGC	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation rewiring degron network	0.1667
p.A556V	DO41361	UCEC	ICGC	PASTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1944
p.T205N	TCGA-AX-A0J0	UCEC	TCGA	PPKY	ITCH	202:205	Mutation altering degron motif	0.7055
p.L545P	TCGA-AX-A2HJ	UCEC	TCGA	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation altering degron motif	0.7582
p.F561L	TCGA-B5-A11N	UCEC	TCGA	PASTT	DEG_SPOP_SBC_1	547:551	Mutation blocking phosphorylation signal	0.5
p.F561L	DO41458	UCEC	ICGC	PASTT	DEG_SPOP_SBC_1	547:551	Mutation blocking phosphorylation signal	0.5
p.S184Y	TCGA-B5-A1MR	UCEC	TCGA	PMSST	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.3056
p.S619N	TCGA-CC-A9FW	LIHC	TCGA	PPEY	ITCH	615:618	Mutation rewiring degron network	0.3056
p.S619N	TCGA-DF-A2KU	UCEC	TCGA	PPEY	ITCH	615:618	Mutation rewiring degron network	0.3056
p.P178T	TCGA-DA-A1I1	SKCM	TCGA	PMSST	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1389
p.L609I	TCGA-E5-A2PC	BLCA	TCGA	PPEY	ITCH	615:618	Mutation rewiring degron network	0.1667
p.D670G	TCGA-E6-A1LX	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.0833
p.P692T	TCGA-EE-A2MP	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.0833
p.K678N	TCGA-EO-A22X	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	679:683	Mutation blocking ubiquitination signal	0.75
p.K678N	DO43907	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	679:683	Mutation blocking ubiquitination signal	0.75
p.T177N	TCGA-EY-A1G8	UCEC	TCGA	PMSST	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.P676S	TCGA-FI-A2D5	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.25
p.P676S	DO41331	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.25
p.L609F	TCGA-FR-A726	SKCM	TCGA	PPEY	ITCH	615:618	Mutation rewiring degron network	0.1667
p.L609F	DO48665	SKCM	ICGC	PPEY	ITCH	615:618	Mutation rewiring degron network	0.1667
p.P490Q	TCGA-FS-A1ZU	SKCM	TCGA	DYR	CBL_MET	480:482	Mutation rewiring degron network	0.1111
p.P490Q	TCGA-FS-A1ZU	SKCM	TCGA	PPDY	ITCH	478:481	Mutation rewiring degron network	0.0833
p.P490Q	DO37723	SKCM	ICGC	DYR	CBL_MET	480:482	Mutation rewiring degron network	0.1111
p.P490Q	DO37723	SKCM	ICGC	PPDY	ITCH	478:481	Mutation rewiring degron network	0.0833
p.D473Y	TCGA-GM-A2DB	BRCA	TCGA	DYR	CBL_MET	480:482	Mutation substituting flanking lysine	0.25
p.D473Y	TCGA-GM-A2DB	BRCA	TCGA	PPDY	ITCH	478:481	Mutation substituting flanking lysine	0.3056
p.D473Y	DO5179	BRCA	ICGC	DYR	CBL_MET	480:482	Mutation substituting flanking lysine	0.25
p.D473Y	DO5179	BRCA	ICGC	PPDY	ITCH	478:481	Mutation substituting flanking lysine	0.3056
p.L553I	TCGA-VQ-A8P2	STAD	TCGA	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation rewiring degron network	0.25
p.L553I	TCGA-VQ-A8P2	STAD	TCGA	PASTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2778
p.L553I	DO51761	STAD	ICGC	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation rewiring degron network	0.25
p.L553I	DO51761	STAD	ICGC	PASTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.2778
p.P485S	DO737	BLCA	ICGC	DYR	CBL_MET	480:482	Mutation rewiring degron network	0.25
p.P485S	DO737	BLCA	ICGC	PPDY	ITCH	478:481	Mutation rewiring degron network	0.2222
p.G205R	DO224700	BRCA	ICGC	PPKY	ITCH	202:205	Mutation altering degron motif	0.7568
p.D481Y	DO224968	BRCA	ICGC	DYR	CBL_MET	480:482	Mutation altering degron motif	0.7325
p.D481Y	DO224968	BRCA	ICGC	PPDY	ITCH	478:481	Mutation altering degron motif	0.7325
p.D481Y	DO227838	BRCA	ICGC	DYR	CBL_MET	480:482	Mutation altering degron motif	0.7325
p.D481Y	DO227838	BRCA	ICGC	PPDY	ITCH	478:481	Mutation altering degron motif	0.7325
p.D549H	DO44242	BRCA	ICGC	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation altering degron motif	0.7688
p.D549H	DO44242	BRCA	ICGC	PASTT	DEG_SPOP_SBC_1	547:551	Mutation altering degron motif	0.7688
p.S204F	DO49962	CESC	ICGC	PPKY	ITCH	202:205	Mutation altering degron motif	0.7982
p.S204F	DO47997	STAD	ICGC	PPKY	ITCH	202:205	Mutation altering degron motif	0.7982
p.E177D	DO223732	CESC	ICGC	PMSST	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.E177D	DO36556	READ	ICGC	PMSST	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.K214N	DO7801	COAD	ICGC	PPKY	ITCH	202:205	Mutation rewiring degron network	0.0833
p.K214N	DO52412	UCEC	ICGC	PPKY	ITCH	202:205	Mutation rewiring degron network	0.0833
p.A480V	DO233697	GACA	ICGC	DYR	CBL_MET	480:482	Mutation altering degron motif	0.6936
p.A480V	DO233697	GACA	ICGC	PPDY	ITCH	478:481	Mutation altering degron motif	0.6936
p.E213K	DO228963	LICA	ICGC	PPKY	ITCH	202:205	Mutation rewiring degron network	0.1111
p.V197F	DO228971	LICA	ICGC	PMSST	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.V197F	DO228971	LICA	ICGC	PPKY	ITCH	202:205	Mutation rewiring degron network	0.1944
p.A556S	DO229032	LICA	ICGC	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation rewiring degron network	0.1667
p.A556S	DO229032	LICA	ICGC	PASTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1944
p.A556S	HMV-II	skin	COSMIC	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation rewiring degron network	0.1667
p.A556S	HMV-II	skin	COSMIC	PASTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1944
p.M538V	DO229156	NKTL	ICGC	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation rewiring degron network	0.1944
p.M538V	DO229156	NKTL	ICGC	PASTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.0833
p.P186Q	DO37738	SKCM	ICGC	PMSST	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.7035
p.L690F	DO43306	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.1389
p.P207L	DO42568	UCEC	ICGC	PPKY	ITCH	202:205	Mutation rewiring degron network	0.2778
p.P691R	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	679:683	Mutation substituting flanking lysine	0.2222
p.P691R	HCC-366	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	679:683	Mutation substituting flanking lysine	0.2222
p.S624N	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	PPEY	ITCH	615:618	Mutation rewiring degron network	0.1667
p.S624N	SIDM00301	Pancreatic Carcinoma	GDSC	PPEY	ITCH	615:618	Mutation rewiring degron network	0.1667
p.S624N	SIDM00576	Acute Myeloid Leukemia	GDSC	PPEY	ITCH	615:618	Mutation rewiring degron network	0.1667
p.E202D	SIDM00899	Pancreatic Carcinoma	GDSC	PPKY	ITCH	202:205	Mutation altering degron motif	0.6758
p.E545V	SIDM01257	Hepatocellular Carcinoma	GDSC	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation altering degron motif	0.7693
p.E545V	SIDM00062	Hepatocellular Carcinoma	GDSC	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation altering degron motif	0.7693
p.E545V	HUH-6-clone5	liver	COSMIC	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation altering degron motif	0.7693
p.M186V	ACH-000047	Gastric Cancer	CCLE	PMSST	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.6097
p.M186V	GCIY	stomach	COSMIC	PMSST	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.6097
p.E199V	ACH-000671	Liver Cancer	CCLE	PMSST	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.E199V	ACH-000671	Liver Cancer	CCLE	PPKY	ITCH	202:205	Mutation rewiring degron network	0.25
p.E199V	ACH-002395	Liver Cancer	CCLE	PMSST	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.E199V	ACH-002395	Liver Cancer	CCLE	PPKY	ITCH	202:205	Mutation rewiring degron network	0.25
p.E199V	HUH-6-clone5	liver	COSMIC	PMSST	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.E199V	HUH-6-clone5	liver	COSMIC	PPKY	ITCH	202:205	Mutation rewiring degron network	0.25
p.R182L	ACH-000994	Endometrial/Uterine Cancer	CCLE	PMSST	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.25
p.R197K	ACH-002300	Lymphoma	CCLE	PMSST	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.R197K	ACH-002300	Lymphoma	CCLE	PPKY	ITCH	202:205	Mutation rewiring degron network	0.1944
p.R197K	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	PMSST	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.1111
p.R197K	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	PPKY	ITCH	202:205	Mutation rewiring degron network	0.1944
p.A671S	Jurkat	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	679:683	Mutation blocking phosphorylation signal	0.5556
p.A196V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PMSST	DEG_SPOP_SBC_1	185:189	Mutation substituting flanking lysine	0.25
p.A196V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPKY	ITCH	202:205	Mutation substituting flanking lysine	0.2778
p.A492S	HMV-II	skin	COSMIC	DYR	CBL_MET	480:482	Mutation blocking ubiquitination signal	0.5
p.R183K	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	PMSST	DEG_SPOP_SBC_1	185:189	Mutation blocking phosphorylation signal	0.7222
p.K692N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.0833
p.P558R	HCC-366	lung	COSMIC	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation rewiring degron network	0.1111
p.P558R	HCC-366	lung	COSMIC	PASTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.K671N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	679:683	Mutation blocking phosphorylation signal	0.5556
p.R544C	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation altering degron motif	0.8301
p.E470V	HUH-6-clone5	liver	COSMIC	DYR	CBL_MET	480:482	Mutation rewiring degron network	0.0556
p.E470V	HUH-6-clone5	liver	COSMIC	PPDY	ITCH	478:481	Mutation rewiring degron network	0.1111
p.P608R	HCC-366	lung	COSMIC	PPEY	ITCH	615:618	Mutation rewiring degron network	0.1389
p.R558C	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation rewiring degron network	0.1111
p.R558C	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	PASTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1389
p.A685S	Jurkat	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.2778
p.K206N	HCC2998	large intestine	COSMIC	PPKY	ITCH	202:205	Mutation rewiring degron network	0.3056
p.A672S	Jurkat	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.1389
p.A613S	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPEY	ITCH	615:618	Mutation blocking phosphorylation signal	0.7222
p.A670S	Jurkat	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.0833
p.P676R	HCC-366	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.25
p.A188V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PMSST	DEG_SPOP_SBC_1	185:189	Mutation altering degron motif	0.6936
p.E471V	HUH-6-clone5	liver	COSMIC	DYR	CBL_MET	480:482	Mutation rewiring degron network	0.0833
p.E471V	HUH-6-clone5	liver	COSMIC	PPDY	ITCH	478:481	Mutation rewiring degron network	0.1389
p.E207V	HUH-6-clone5	liver	COSMIC	PPKY	ITCH	202:205	Mutation rewiring degron network	0.2778
p.E484V	HUH-6-clone5	liver	COSMIC	DYR	CBL_MET	480:482	Mutation rewiring degron network	0.2778
p.E484V	HUH-6-clone5	liver	COSMIC	PPDY	ITCH	478:481	Mutation rewiring degron network	0.25
p.A479S	HMV-II	skin	COSMIC	PPDY	ITCH	478:481	Mutation altering degron motif	0.7588
p.S196I	NB5	autonomic ganglia	COSMIC	PMSST	DEG_SPOP_SBC_1	185:189	Mutation substituting flanking lysine	0.25
p.S196I	NB5	autonomic ganglia	COSMIC	PPKY	ITCH	202:205	Mutation substituting flanking lysine	0.2778
p.P617R	HCC-366	lung	COSMIC	PPEY	ITCH	615:618	Mutation altering degron motif	0.7512
p.P616R	HCC-366	lung	COSMIC	PPEY	ITCH	615:618	Mutation altering degron motif	0.7512
p.A210V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPKY	ITCH	202:205	Mutation rewiring degron network	0.1944
p.R545C	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation altering degron motif	0.8301
p.A193T	SNU-1040	large intestine	COSMIC	PMSST	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.2222
p.A193T	SNU-1040	large intestine	COSMIC	PPKY	ITCH	202:205	Mutation rewiring degron network	0.0833
p.R175K	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	PMSST	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.0556
p.K182N	FTC-133	thyroid	COSMIC	PMSST	DEG_SPOP_SBC_1	185:189	Mutation rewiring degron network	0.25
p.R486C	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	480:482	Mutation rewiring degron network	0.2222
p.R486C	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	PPDY	ITCH	478:481	Mutation rewiring degron network	0.1944
p.A560S	HMV-II	skin	COSMIC	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation blocking phosphorylation signal	0.5
p.A560S	HMV-II	skin	COSMIC	PASTT	DEG_SPOP_SBC_1	547:551	Mutation blocking phosphorylation signal	0.5278
p.P615R	HCC-366	lung	COSMIC	PPEY	ITCH	615:618	Mutation altering degron motif	0.7512
p.P672R	HCC-366	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.1389
p.K684N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.3056
p.K691N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	679:683	Mutation substituting flanking lysine	0.2222
p.R619C	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	PPEY	ITCH	615:618	Mutation rewiring degron network	0.3056
p.K542N	FTC-133	thyroid	COSMIC	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation rewiring degron network	0.3056
p.K542N	FTC-133	thyroid	COSMIC	PASTT	DEG_SPOP_SBC_1	547:551	Mutation rewiring degron network	0.1944
p.R536C	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	VSQTPAST	DEG_SCF_FBW7_1	543:550	Mutation rewiring degron network	0.1389
p.K693N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	679:683	Mutation substituting flanking lysine	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CAST

UniProt ID: P20810

Entrez ID: 831

Protein name: Calpastatin (Calpain inhibitor) (Sperm BS-17 component)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CAST in