DegronMD

Uniprot ID: P20810

Source protein: Calpastatin

Source gene: CAST

Class: DEG_SCF_FBW7_1

Location: 543:550

E3 ligase: FBXW7

DEGRON score: 0.9841

ASA_SCORE: 84.9

COIL: 0.8951

CONS_SCORE: 0.6372

DSS_SCORE: 0.5714

HELIX: 0.0371

FCONS_SCORE: 1.1686

RIG_SCORE: 0.668

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E559K	TCGA-78-7539	LUAD	TCGA	VSQTPAST	DEG_SCF_FBW7_1	0.0833
p.E559K	DO26210	LUAD	ICGC	VSQTPAST	DEG_SCF_FBW7_1	0.0833
p.A556V	TCGA-AP-A059	UCEC	TCGA	VSQTPAST	DEG_SCF_FBW7_1	0.1667
p.A556V	DO41361	UCEC	ICGC	VSQTPAST	DEG_SCF_FBW7_1	0.1667
p.L545P	TCGA-AX-A2HJ	UCEC	TCGA	VSQTPAST	DEG_SCF_FBW7_1	0.7582
p.L553I	TCGA-VQ-A8P2	STAD	TCGA	VSQTPAST	DEG_SCF_FBW7_1	0.25
p.L553I	DO51761	STAD	ICGC	VSQTPAST	DEG_SCF_FBW7_1	0.25
p.D549H	DO44242	BRCA	ICGC	VSQTPAST	DEG_SCF_FBW7_1	0.7688
p.A556S	DO229032	LICA	ICGC	VSQTPAST	DEG_SCF_FBW7_1	0.1667
p.A556S	HMV-II	skin	COSMIC	VSQTPAST	DEG_SCF_FBW7_1	0.1667
p.M538V	DO229156	NKTL	ICGC	VSQTPAST	DEG_SCF_FBW7_1	0.1944
p.E545V	SIDM01257	Hepatocellular Carcinoma	GDSC	VSQTPAST	DEG_SCF_FBW7_1	0.7693
p.E545V	SIDM00062	Hepatocellular Carcinoma	GDSC	VSQTPAST	DEG_SCF_FBW7_1	0.7693
p.E545V	HUH-6-clone5	liver	COSMIC	VSQTPAST	DEG_SCF_FBW7_1	0.7693
p.P558R	HCC-366	lung	COSMIC	VSQTPAST	DEG_SCF_FBW7_1	0.1111
p.R544C	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	VSQTPAST	DEG_SCF_FBW7_1	0.8301
p.R558C	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	VSQTPAST	DEG_SCF_FBW7_1	0.1111
p.R545C	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	VSQTPAST	DEG_SCF_FBW7_1	0.8301
p.A560S	HMV-II	skin	COSMIC	VSQTPAST	DEG_SCF_FBW7_1	0.5
p.K542N	FTC-133	thyroid	COSMIC	VSQTPAST	DEG_SCF_FBW7_1	0.3056
p.R536C	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	VSQTPAST	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20810	Calpastatin	DEG_SCF_FBW7_1	543:550	VSQTPAST	FBXW7	0.9841	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons