DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPDY
Uniprot ID:
P20810
Source protein:
Calpastatin
Source gene:
CAST
Class:
ITCH
Location:
478:481
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.9995
ASA_SCORE:
80.775
COIL:
0.9285
CONS_SCORE:
0.8045
DSS_SCORE:
0.6032
HELIX:
0.045
FCONS_SCORE:
1.0787
RIG_SCORE:
0.7144
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A479S
HMV-II
skin
COSMIC
PPDY
ITCH
0.7588
p.D481Y
DO224968
BRCA
ICGC
PPDY
ITCH
0.7325
p.D481Y
DO227838
BRCA
ICGC
PPDY
ITCH
0.7325
p.A480V
DO233697
GACA
ICGC
PPDY
ITCH
0.6936
p.D473Y
TCGA-GM-A2DB
BRCA
TCGA
PPDY
ITCH
0.3056
p.D473Y
DO5179
BRCA
ICGC
PPDY
ITCH
0.3056
p.E487D
TCGA-A5-A0GB
UCEC
TCGA
PPDY
ITCH
0.2778
p.E487D
DO41434
UCEC
ICGC
PPDY
ITCH
0.2778
p.E484V
HUH-6-clone5
liver
COSMIC
PPDY
ITCH
0.25
p.P485S
DO737
BLCA
ICGC
PPDY
ITCH
0.2222
p.R486C
ALL-SIL
haematopoietic_and_lymphoid_tissue
COSMIC
PPDY
ITCH
0.1944
p.E471V
HUH-6-clone5
liver
COSMIC
PPDY
ITCH
0.1389
p.E470V
HUH-6-clone5
liver
COSMIC
PPDY
ITCH
0.1111
p.P490Q
TCGA-FS-A1ZU
SKCM
TCGA
PPDY
ITCH
0.0833
p.P490Q
DO37723
SKCM
ICGC
PPDY
ITCH
0.0833
Showing 1 to 15 of 15 entries
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Drug responses associated with CAST mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PPDY
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q13405
39S ribosomal protein L49, mitochondrial
ITCH
32:35
PPDY
ITCH,NEDD4
0.9394
More...
Q8IZP9
Adhesion G-protein coupled receptor G2
ITCH
282:285
PPDY
ITCH,NEDD4
0.8863
More...
Q9UQB8
Brain-specific angiogenesis inhibitor 1-associated protein 2
ITCH
468:471
PPDY
ITCH,NEDD4
0.9965
More...
Q9UHR4
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
ITCH
436:439
PPDY
ITCH,NEDD4
0.9989
More...
P20810
Calpastatin
ITCH
478:481
PPDY
ITCH,NEDD4
0.9995
More...
O95985
DNA topoisomerase 3-beta-1
ITCH
490:493
PPDY
ITCH,NEDD4
0.8044
More...
Q6ZR08
Dynein axonemal heavy chain 12
ITCH
78:81
PPDY
ITCH,NEDD4
0.9568
More...
Q8TE73
Dynein axonemal heavy chain 5
ITCH
4368:4371
PPDY
ITCH,NEDD4
0.9769
More...
Q96JB1
Dynein axonemal heavy chain 8
ITCH
4233:4236
PPDY
ITCH,NEDD4
0.9067
More...
Q8N7E2
E3 ubiquitin-protein ligase CBLL2
ITCH
256:259
PPDY
ITCH,NEDD4
0.9915
More...
Q9UBS8
E3 ubiquitin-protein ligase RNF14
ITCH
80:83
PPDY
ITCH,NEDD4
0.791
More...
Q96I24
Far upstream element-binding protein 3
ITCH
540:543
PPDY
ITCH,NEDD4
0.995
More...
Q4L180
Filamin A-interacting protein 1-like
ITCH
809:812
PPDY
ITCH,NEDD4
0.861
More...
Q5T442
Gap junction gamma-2 protein
ITCH
330:333
PPDY
ITCH,NEDD4
0.9661
More...
Q8IUY3
GRAM domain-containing protein 2A
ITCH
41:44
PPDY
ITCH,NEDD4
0.9404
More...
P61296
Heart- and neural crest derivatives-expressed protein 2
ITCH
55:58
PPDY
ITCH,NEDD4
0.829
More...
O43390
Heterogeneous nuclear ribonucleoprotein R
ITCH
461:464
PPDY
ITCH,NEDD4
0.6735
More...
Q6UWN5
Ly6/PLAUR domain-containing protein 5
ITCH
94:97
PPDY
ITCH,NEDD4
0.7174
More...
Q8IZL2
Mastermind-like protein 2
ITCH
127:130
PPDY
ITCH,NEDD4
0.9403
More...
Q8IZL2
Mastermind-like protein 2
ITCH
798:801
PPDY
ITCH,NEDD4
0.8792
More...
P17568
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
ITCH
26:29
PPDY
ITCH,NEDD4
0.9726
More...
Q8WY41
Nanos homolog 1
ITCH
102:105
PPDY
ITCH,NEDD4
0.9214
More...
Q8N2Q7
Neuroligin-1
ITCH
799:802
PPDY
ITCH,NEDD4
0.9681
More...
Q8NFZ4
Neuroligin-2
ITCH
766:769
PPDY
ITCH,NEDD4
0.9784
More...
Q8N0W4
Neuroligin-4, X-linked
ITCH
757:760
PPDY
ITCH,NEDD4
0.9948
More...
Showing 1 to 25 of 48 entries
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