DegronMD - Q96KP6(TNIP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S293L	TCGA-66-2782	LUSC	TCGA	PPDY	ITCH	295:298	Mutation rewiring degron network	0.2778
p.F288V	TCGA-AG-3892	READ	TCGA	PPDY	ITCH	295:298	Mutation rewiring degron network	0.1389
p.F288V	DO36394	READ	ICGC	PPDY	ITCH	295:298	Mutation rewiring degron network	0.1389
p.E285K	TCGA-CA-6717	COAD	TCGA	PPDY	ITCH	295:298	Mutation rewiring degron network	0.0556
p.E285K	TCGA-D9-A6EC	SKCM	TCGA	PPDY	ITCH	295:298	Mutation rewiring degron network	0.0556
p.E285K	TCGA-EE-A29M	SKCM	TCGA	PPDY	ITCH	295:298	Mutation rewiring degron network	0.0556
p.E285K	TCGA-EI-6917	READ	TCGA	PPDY	ITCH	295:298	Mutation rewiring degron network	0.0556
p.E285K	TCGA-FR-A726	SKCM	TCGA	PPDY	ITCH	295:298	Mutation rewiring degron network	0.0556
p.Q300R	TCGA-DU-6392	LGG	TCGA	PPDY	ITCH	295:298	Mutation rewiring degron network	0.2778
p.Q300R	DO22237	LGG	ICGC	PPDY	ITCH	295:298	Mutation rewiring degron network	0.2778
p.R297G	TCGA-DX-A6YU	SARC	TCGA	PPDY	ITCH	295:298	Mutation altering degron motif	0.7568
p.R297G	DO220009	SARC	ICGC	PPDY	ITCH	295:298	Mutation altering degron motif	0.7568
p.R295Q	TCGA-EB-A6QY	SKCM	TCGA	PPDY	ITCH	295:298	Mutation altering degron motif	0.7329
p.R295Q	TCGA-EE-A3JB	SKCM	TCGA	PPDY	ITCH	295:298	Mutation altering degron motif	0.7329
p.R295Q	DO48702	SKCM	ICGC	PPDY	ITCH	295:298	Mutation altering degron motif	0.7329
p.R295Q	DO51250	SKCM	ICGC	PPDY	ITCH	295:298	Mutation altering degron motif	0.7329
p.P307S	DO44111	BRCA	ICGC	PPDY	ITCH	295:298	Mutation rewiring degron network	0.0833
p.N299H	DO231007	LUSC	ICGC	PPDY	ITCH	295:298	Mutation rewiring degron network	0.3056
p.W300L	DO45490	LUSC	ICGC	PPDY	ITCH	295:298	Mutation rewiring degron network	0.2778
p.W300L	DO37831	SKCM	ICGC	PPDY	ITCH	295:298	Mutation rewiring degron network	0.2778
p.D297Y	DO41361	UCEC	ICGC	PPDY	ITCH	295:298	Mutation altering degron motif	0.6214
p.D297Y	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PPDY	ITCH	295:298	Mutation altering degron motif	0.6214
p.D297Y	ACH-000983	Leukemia	CCLE	PPDY	ITCH	295:298	Mutation altering degron motif	0.6214
p.D297Y	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PPDY	ITCH	295:298	Mutation altering degron motif	0.6214

Kaplan plot for TNIP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNIP3

UniProt ID: Q96KP6

Entrez ID: 79931

Protein name: TNFAIP3-interacting protein 3 (A20-binding inhibitor of NF-kappa-B activation 3) (ABIN-3) (Listeria-induced gene protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNIP3 in