DegronMD

Uniprot ID: Q96KP6

Source protein: TNFAIP3-interacting protein 3

Source gene: TNIP3

Class: ITCH

Location: 295:298

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9842

ASA_SCORE: 62

COIL: 0.854

CONS_SCORE: 0.6991

DSS_SCORE: 0.5204

HELIX: 0.1175

FCONS_SCORE: 1.1736

RIG_SCORE: 0.7509

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R297G	TCGA-DX-A6YU	SARC	TCGA	PPDY	ITCH	0.7568
p.R297G	DO220009	SARC	ICGC	PPDY	ITCH	0.7568
p.R295Q	TCGA-EB-A6QY	SKCM	TCGA	PPDY	ITCH	0.7329
p.R295Q	TCGA-EE-A3JB	SKCM	TCGA	PPDY	ITCH	0.7329
p.R295Q	DO48702	SKCM	ICGC	PPDY	ITCH	0.7329
p.R295Q	DO51250	SKCM	ICGC	PPDY	ITCH	0.7329
p.D297Y	DO41361	UCEC	ICGC	PPDY	ITCH	0.6214
p.D297Y	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PPDY	ITCH	0.6214
p.D297Y	ACH-000983	Leukemia	CCLE	PPDY	ITCH	0.6214
p.D297Y	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PPDY	ITCH	0.6214
p.N299H	DO231007	LUSC	ICGC	PPDY	ITCH	0.3056
p.S293L	TCGA-66-2782	LUSC	TCGA	PPDY	ITCH	0.2778
p.Q300R	TCGA-DU-6392	LGG	TCGA	PPDY	ITCH	0.2778
p.Q300R	DO22237	LGG	ICGC	PPDY	ITCH	0.2778
p.W300L	DO45490	LUSC	ICGC	PPDY	ITCH	0.2778
p.W300L	DO37831	SKCM	ICGC	PPDY	ITCH	0.2778
p.F288V	TCGA-AG-3892	READ	TCGA	PPDY	ITCH	0.1389
p.F288V	DO36394	READ	ICGC	PPDY	ITCH	0.1389
p.P307S	DO44111	BRCA	ICGC	PPDY	ITCH	0.0833
p.E285K	TCGA-CA-6717	COAD	TCGA	PPDY	ITCH	0.0556
p.E285K	TCGA-D9-A6EC	SKCM	TCGA	PPDY	ITCH	0.0556
p.E285K	TCGA-EE-A29M	SKCM	TCGA	PPDY	ITCH	0.0556
p.E285K	TCGA-EI-6917	READ	TCGA	PPDY	ITCH	0.0556
p.E285K	TCGA-FR-A726	SKCM	TCGA	PPDY	ITCH	0.0556

Showing 1 to 24 of 24 entries

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Drug responses associated with TNIP3 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPDY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13405	39S ribosomal protein L49, mitochondrial	ITCH	32:35	PPDY	ITCH,NEDD4	0.9394	More...
Q8IZP9	Adhesion G-protein coupled receptor G2	ITCH	282:285	PPDY	ITCH,NEDD4	0.8863	More...
Q9UQB8	Brain-specific angiogenesis inhibitor 1-associated protein 2	ITCH	468:471	PPDY	ITCH,NEDD4	0.9965	More...
Q9UHR4	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1	ITCH	436:439	PPDY	ITCH,NEDD4	0.9989	More...
P20810	Calpastatin	ITCH	478:481	PPDY	ITCH,NEDD4	0.9995	More...
O95985	DNA topoisomerase 3-beta-1	ITCH	490:493	PPDY	ITCH,NEDD4	0.8044	More...
Q6ZR08	Dynein axonemal heavy chain 12	ITCH	78:81	PPDY	ITCH,NEDD4	0.9568	More...
Q8TE73	Dynein axonemal heavy chain 5	ITCH	4368:4371	PPDY	ITCH,NEDD4	0.9769	More...
Q96JB1	Dynein axonemal heavy chain 8	ITCH	4233:4236	PPDY	ITCH,NEDD4	0.9067	More...
Q8N7E2	E3 ubiquitin-protein ligase CBLL2	ITCH	256:259	PPDY	ITCH,NEDD4	0.9915	More...
Q9UBS8	E3 ubiquitin-protein ligase RNF14	ITCH	80:83	PPDY	ITCH,NEDD4	0.791	More...
Q96I24	Far upstream element-binding protein 3	ITCH	540:543	PPDY	ITCH,NEDD4	0.995	More...
Q4L180	Filamin A-interacting protein 1-like	ITCH	809:812	PPDY	ITCH,NEDD4	0.861	More...
Q5T442	Gap junction gamma-2 protein	ITCH	330:333	PPDY	ITCH,NEDD4	0.9661	More...
Q8IUY3	GRAM domain-containing protein 2A	ITCH	41:44	PPDY	ITCH,NEDD4	0.9404	More...
P61296	Heart- and neural crest derivatives-expressed protein 2	ITCH	55:58	PPDY	ITCH,NEDD4	0.829	More...
O43390	Heterogeneous nuclear ribonucleoprotein R	ITCH	461:464	PPDY	ITCH,NEDD4	0.6735	More...
Q6UWN5	Ly6/PLAUR domain-containing protein 5	ITCH	94:97	PPDY	ITCH,NEDD4	0.7174	More...
Q8IZL2	Mastermind-like protein 2	ITCH	127:130	PPDY	ITCH,NEDD4	0.9403	More...
Q8IZL2	Mastermind-like protein 2	ITCH	798:801	PPDY	ITCH,NEDD4	0.8792	More...
P17568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	ITCH	26:29	PPDY	ITCH,NEDD4	0.9726	More...
Q8WY41	Nanos homolog 1	ITCH	102:105	PPDY	ITCH,NEDD4	0.9214	More...
Q8N2Q7	Neuroligin-1	ITCH	799:802	PPDY	ITCH,NEDD4	0.9681	More...
Q8NFZ4	Neuroligin-2	ITCH	766:769	PPDY	ITCH,NEDD4	0.9784	More...
Q8N0W4	Neuroligin-4, X-linked	ITCH	757:760	PPDY	ITCH,NEDD4	0.9948	More...

Showing 1 to 25 of 48 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPDY

Degron related mutations and impact score

Drug responses associated with TNIP3 mutations

All proteins holding degron of PPDY