DegronMD - O95985(TOP3B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E498K	TCGA-18-3409	LUSC	TCGA	PPDY	ITCH	490:493	Mutation rewiring degron network	0.1944
p.E498K	TCGA-XF-AAML	BLCA	TCGA	PPDY	ITCH	490:493	Mutation rewiring degron network	0.1944
p.A405S	TCGA-44-7661	LUAD	TCGA	PPITPMKS	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.0556
p.T495M	TCGA-B5-A3FC	UCEC	TCGA	PPDY	ITCH	490:493	Mutation rewiring degron network	0.2778
p.E480K	TCGA-CV-7425	HNSC	TCGA	PPDY	ITCH	490:493	Mutation rewiring degron network	0.0556
p.A396G	TCGA-D9-A6EA	SKCM	TCGA	PPITPMKS	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.3056
p.D383G	TCGA-DI-A1BU	UCEC	TCGA	PPITPMKS	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.1944
p.L499F	TCGA-ER-A193	SKCM	TCGA	PPDY	ITCH	490:493	Mutation rewiring degron network	0.1667
p.R379Q	TCGA-GN-A4U7	SKCM	TCGA	PPITPMKS	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.0833
p.E398D	TCGA-L5-A8NM	ESCA	TCGA	PPITPMKS	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.25
p.T488M	SIDM00683	Prostate Carcinoma	GDSC	PPDY	ITCH	490:493	Mutation rewiring degron network	0.2778
p.T488M	ACH-000977	lymph node	CCLE	PPDY	ITCH	490:493	Mutation rewiring degron network	0.2778
p.T488M	LNCaP-Clone-FGC	prostate	COSMIC	PPDY	ITCH	490:493	Mutation rewiring degron network	0.2778
p.A384V	SIDM00781	Colorectal Carcinoma	GDSC	PPITPMKS	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.2222
p.A384V	SIDM00780	Colorectal Carcinoma	GDSC	PPITPMKS	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.2222
p.A384V	ACH-000967	Colon/Colorectal Cancer	CCLE	PPITPMKS	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.2222
p.A384V	ACH-001199	Colon/Colorectal Cancer	CCLE	PPITPMKS	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.2222
p.A384V	SNU-C2B	large intestine	COSMIC	PPITPMKS	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.2222
p.A405V	SIDM00889	Cervical Carcinoma	GDSC	PPITPMKS	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.0556
p.A405V	C-33-A	cervix	COSMIC	PPITPMKS	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.0556
p.P378L	SIDM00333	Endometrial Carcinoma	GDSC	PPITPMKS	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.0556
p.P378L	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPITPMKS	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.0556
p.P378L	MFE-319	endometrium	COSMIC	PPITPMKS	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.0556

Kaplan plot for TOP3B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TOP3B

UniProt ID: O95985

Entrez ID: 8940

Protein name: DNA topoisomerase 3-beta-1 (EC 5.6.2.1) (DNA topoisomerase III beta-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TOP3B in