DegronMD

Uniprot ID: O95985

Source protein: DNA topoisomerase 3-beta-1

Source gene: TOP3B

Class: DEG_SCF_FBW7_1

Location: 388:395

E3 ligase: FBXW7

DEGRON score: 0.8141

ASA_SCORE: 63.0875

COIL: 0.8229

CONS_SCORE: 0.5608

DSS_SCORE: 0.6366

HELIX: 0.0318

FCONS_SCORE: 1.3826

RIG_SCORE: 0.6871

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A405S	TCGA-44-7661	LUAD	TCGA	PPITPMKS	DEG_SCF_FBW7_1	0.0556
p.A396G	TCGA-D9-A6EA	SKCM	TCGA	PPITPMKS	DEG_SCF_FBW7_1	0.3056
p.D383G	TCGA-DI-A1BU	UCEC	TCGA	PPITPMKS	DEG_SCF_FBW7_1	0.1944
p.R379Q	TCGA-GN-A4U7	SKCM	TCGA	PPITPMKS	DEG_SCF_FBW7_1	0.0833
p.E398D	TCGA-L5-A8NM	ESCA	TCGA	PPITPMKS	DEG_SCF_FBW7_1	0.25
p.A384V	SIDM00781	Colorectal Carcinoma	GDSC	PPITPMKS	DEG_SCF_FBW7_1	0.2222
p.A384V	SIDM00780	Colorectal Carcinoma	GDSC	PPITPMKS	DEG_SCF_FBW7_1	0.2222
p.A384V	ACH-000967	Colon/Colorectal Cancer	CCLE	PPITPMKS	DEG_SCF_FBW7_1	0.2222
p.A384V	ACH-001199	Colon/Colorectal Cancer	CCLE	PPITPMKS	DEG_SCF_FBW7_1	0.2222
p.A384V	SNU-C2B	large_intestine	COSMIC	PPITPMKS	DEG_SCF_FBW7_1	0.2222
p.A405V	SIDM00889	Cervical Carcinoma	GDSC	PPITPMKS	DEG_SCF_FBW7_1	0.0556
p.A405V	C-33-A	cervix	COSMIC	PPITPMKS	DEG_SCF_FBW7_1	0.0556
p.P378L	SIDM00333	Endometrial Carcinoma	GDSC	PPITPMKS	DEG_SCF_FBW7_1	0.0556
p.P378L	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPITPMKS	DEG_SCF_FBW7_1	0.0556
p.P378L	MFE-319	endometrium	COSMIC	PPITPMKS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95985	DNA topoisomerase 3-beta-1	DEG_SCF_FBW7_1	388:395	PPITPMKS	FBXW7	0.8141	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons