DegronMD - Q9UQB8(BAIAP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R476Q	TCGA-55-7907	LUAD	TCGA	PPDY	ITCH	468:471	Mutation rewiring degron network	0.1944
p.R476Q	DO25396	LUAD	ICGC	PPDY	ITCH	468:471	Mutation rewiring degron network	0.1944
p.P342H	TCGA-AB-2883	LAML	TCGA	VTPKNS	DEG_SCF_FBW7_1	347:352	Mutation rewiring degron network	0.1944
p.R373C	TCGA-AX-A0J0	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.1389
p.S366F	TCGA-BF-AAP2	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	362:366	Mutation altering degron motif	0.9093
p.L371P	TCGA-BR-6852	STAD	TCGA	PRSSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.1944
p.D470N	TCGA-CM-4752	COAD	TCGA	PPDY	ITCH	468:471	Mutation altering degron motif	0.5821
p.D470N	DO9322	COAD	ICGC	PPDY	ITCH	468:471	Mutation altering degron motif	0.5821
p.P342L	TCGA-DD-AACP	LIHC	TCGA	VTPKNS	DEG_SCF_FBW7_1	347:352	Mutation rewiring degron network	0.1944
p.L459M	TCGA-DU-6392	LGG	TCGA	PPDY	ITCH	468:471	Mutation rewiring degron network	0.0833
p.L459M	DO22237	LGG	ICGC	PPDY	ITCH	468:471	Mutation rewiring degron network	0.0833
p.P479S	TCGA-EE-A182	SKCM	TCGA	PPDY	ITCH	468:471	Mutation rewiring degron network	0.1111
p.P479S	DO37814	SKCM	ICGC	PPDY	ITCH	468:471	Mutation rewiring degron network	0.1111
p.R376C	TCGA-FI-A2F4	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.0556
p.R376C	SIDM01409	Bladder Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.0556
p.P467Q	TCGA-FS-A1ZN	SKCM	TCGA	PPDY	ITCH	468:471	Mutation rewiring degron network	0.3056
p.P467Q	DO38165	SKCM	ICGC	PPDY	ITCH	468:471	Mutation rewiring degron network	0.3056
p.K344N	DO3110	BRCA	ICGC	VTPKNS	DEG_SCF_FBW7_1	347:352	Mutation rewiring degron network	0.25
p.G472S	DO3110	BRCA	ICGC	PPDY	ITCH	468:471	Mutation rewiring degron network	0.3056
p.A465S	DO229027	LICA	ICGC	PPDY	ITCH	468:471	Mutation rewiring degron network	0.25
p.A480S	DO229038	LICA	ICGC	PPDY	ITCH	468:471	Mutation rewiring degron network	0.0833
p.K344T	DO43186	UCEC	ICGC	VTPKNS	DEG_SCF_FBW7_1	347:352	Mutation rewiring degron network	0.25
p.K359R	SIDM00698	Small Cell Lung Carcinoma	GDSC	VTPKNS	DEG_SCF_FBW7_1	347:352	Mutation blocking ubiquitination signal	0.5833
p.K359R	SIDM00698	Small Cell Lung Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	362:366	Mutation blocking ubiquitination signal	0.6944
p.K359R	NCI-H146	lung	COSMIC	VTPKNS	DEG_SCF_FBW7_1	347:352	Mutation blocking ubiquitination signal	0.5833
p.K359R	NCI-H146	lung	COSMIC	PRSSS	DEG_SPOP_SBC_1	362:366	Mutation blocking ubiquitination signal	0.6944
p.R344G	SIDM00789	Colorectal Carcinoma	GDSC	VTPKNS	DEG_SCF_FBW7_1	347:352	Mutation rewiring degron network	0.25
p.R344G	HCT-15	large intestine	COSMIC	VTPKNS	DEG_SCF_FBW7_1	347:352	Mutation rewiring degron network	0.25
p.S352G	SIDM01045	Endometrial Carcinoma	GDSC	VTPKNS	DEG_SCF_FBW7_1	347:352	Mutation altering degron motif	0.8104
p.S352G	EN	endometrium	COSMIC	VTPKNS	DEG_SCF_FBW7_1	347:352	Mutation altering degron motif	0.8104
p.T356I	SIDM00217	Colorectal Carcinoma	GDSC	VTPKNS	DEG_SCF_FBW7_1	347:352	Mutation blocking phosphorylation signal	0.6667
p.T356I	SIDM00217	Colorectal Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	362:366	Mutation blocking phosphorylation signal	0.6111
p.T356I	SNU-1040	large intestine	COSMIC	VTPKNS	DEG_SCF_FBW7_1	347:352	Mutation blocking phosphorylation signal	0.6667
p.T356I	SNU-1040	large intestine	COSMIC	PRSSS	DEG_SPOP_SBC_1	362:366	Mutation blocking phosphorylation signal	0.6111
p.L361M	ACH-000669	Lung Cancer	CCLE	VTPKNS	DEG_SCF_FBW7_1	347:352	Mutation rewiring degron network	0.0833
p.L361M	ACH-000669	Lung Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.3056
p.S355G	ACH-000988	Endometrial/Uterine Cancer	CCLE	VTPKNS	DEG_SCF_FBW7_1	347:352	Mutation rewiring degron network	0.25
p.S355G	ACH-000988	Endometrial/Uterine Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.1389
p.S355G	MFE-319	endometrium	COSMIC	VTPKNS	DEG_SCF_FBW7_1	347:352	Mutation rewiring degron network	0.25
p.S355G	MFE-319	endometrium	COSMIC	PRSSS	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.1389
p.S352R	NCI-H630	large intestine	COSMIC	VTPKNS	DEG_SCF_FBW7_1	347:352	Mutation altering degron motif	0.8538
p.Y343F	HMV-II	skin	COSMIC	VTPKNS	DEG_SCF_FBW7_1	347:352	Mutation rewiring degron network	0.2222
p.S364N	NCI-H2085	lung	COSMIC	PRSSS	DEG_SPOP_SBC_1	362:366	Mutation altering degron motif	0.818
p.P360L	MONO-MAC-6	haematopoietic and lymphoid tissue	COSMIC	VTPKNS	DEG_SCF_FBW7_1	347:352	Mutation blocking phosphorylation signal	0.5556
p.P360L	MONO-MAC-6	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	362:366	Mutation blocking phosphorylation signal	0.7222

Kaplan plot for BAIAP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BAIAP2

UniProt ID: Q9UQB8

Entrez ID: 10458

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BAIAP2 in