DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PRSSS
Uniprot ID:
Q9UQB8
Source protein:
Brain-specific angiogenesis inhibitor 1-associated protein 2
Source gene:
BAIAP2
Class:
DEG_SPOP_SBC_1
Location:
362:366
E3 ligase:
SPOP
DEGRON score:
0.9997
ASA_SCORE:
72.48
COIL:
0.7778
CONS_SCORE:
0.408
DSS_SCORE:
0.5642
HELIX:
0.1518
FCONS_SCORE:
1.0513
RIG_SCORE:
0.72
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R373C
TCGA-AX-A0J0
UCEC
TCGA
PRSSS
DEG_SPOP_SBC_1
0.1389
p.S366F
TCGA-BF-AAP2
SKCM
TCGA
PRSSS
DEG_SPOP_SBC_1
0.9093
p.L371P
TCGA-BR-6852
STAD
TCGA
PRSSS
DEG_SPOP_SBC_1
0.1944
p.R376C
TCGA-FI-A2F4
UCEC
TCGA
PRSSS
DEG_SPOP_SBC_1
0.0556
p.R376C
SIDM01409
Bladder Carcinoma
GDSC
PRSSS
DEG_SPOP_SBC_1
0.0556
p.K359R
SIDM00698
Small Cell Lung Carcinoma
GDSC
PRSSS
DEG_SPOP_SBC_1
0.6944
p.K359R
NCI-H146
lung
COSMIC
PRSSS
DEG_SPOP_SBC_1
0.6944
p.T356I
SIDM00217
Colorectal Carcinoma
GDSC
PRSSS
DEG_SPOP_SBC_1
0.6111
p.T356I
SNU-1040
large_intestine
COSMIC
PRSSS
DEG_SPOP_SBC_1
0.6111
p.L361M
ACH-000669
Lung Cancer
CCLE
PRSSS
DEG_SPOP_SBC_1
0.3056
p.S355G
ACH-000988
Endometrial/Uterine Cancer
CCLE
PRSSS
DEG_SPOP_SBC_1
0.1389
p.S355G
MFE-319
endometrium
COSMIC
PRSSS
DEG_SPOP_SBC_1
0.1389
p.S364N
NCI-H2085
lung
COSMIC
PRSSS
DEG_SPOP_SBC_1
0.818
p.P360L
MONO-MAC-6
haematopoietic_and_lymphoid_tissue
COSMIC
PRSSS
DEG_SPOP_SBC_1
0.7222
Drug responses associated with BAIAP2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PRSSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A7KAX9
Rho GTPase-activating protein 32
DEG_SPOP_SBC_1
728:732
PRSSS
SPOP
0.9943
More...
O75069
Transmembrane and coiled-coil domains protein 2
DEG_SPOP_SBC_1
218:222
PRSSS
SPOP
0.6944
More...
O75081
Protein CBFA2T3
DEG_SPOP_SBC_1
455:459
PRSSS
SPOP
0.6229
More...
O75592
E3 ubiquitin-protein ligase MYCBP2
DEG_SPOP_SBC_1
2840:2844
PRSSS
SPOP
0.9962
More...
O94876
Transmembrane and coiled-coil domains protein 1
DEG_SPOP_SBC_1
154:158
PRSSS
SPOP
0.9256
More...
O94964
Protein SOGA1
DEG_SPOP_SBC_1
1168:1172
PRSSS
SPOP
0.9994
More...
P41182
B-cell lymphoma 6 protein
DEG_SPOP_SBC_1
458:462
PRSSS
SPOP
0.5537
More...
P49619
Diacylglycerol kinase gamma
DEG_SPOP_SBC_1
149:153
PRSSS
SPOP
0.5556
More...
P55201
Peregrin
DEG_SPOP_SBC_1
995:999
PRSSS
SPOP
0.9038
More...
P78386
Keratin, type II cuticular Hb5
DEG_SPOP_SBC_1
491:495
PRSSS
SPOP
0.8473
More...
P98177
Forkhead box protein O4
DEG_SPOP_SBC_1
258:262
PRSSS
SPOP
0.9997
More...
Q13478
Interleukin-18 receptor 1
DEG_SPOP_SBC_1
70:74
PRSSS
SPOP
0.7325
More...
Q13515
Phakinin
DEG_SPOP_SBC_1
30:34
PRSSS
SPOP
0.9701
More...
Q15431
Synaptonemal complex protein 1
DEG_SPOP_SBC_1
13:17
PRSSS
SPOP
0.9396
More...
Q5CZC0
Fibrous sheath-interacting protein 2
DEG_SPOP_SBC_1
4128:4132
PRSSS
SPOP
0.709
More...
Q5SQI0
Alpha-tubulin N-acetyltransferase 1
DEG_SPOP_SBC_1
268:272
PRSSS
SPOP
0.9882
More...
Q6GYQ0
Ral GTPase-activating protein subunit alpha-1
DEG_SPOP_SBC_1
793:797
PRSSS
SPOP
0.9994
More...
Q6IQ55
Tau-tubulin kinase 2
DEG_SPOP_SBC_1
1155:1159
PRSSS
SPOP
0.8733
More...
Q86TC9
Myopalladin
DEG_SPOP_SBC_1
588:592
PRSSS
SPOP
0.7566
More...
Q86UU0
B-cell CLL/lymphoma 9-like protein
DEG_SPOP_SBC_1
1049:1053
PRSSS
SPOP
0.9955
More...
Q8N2C7
Protein unc-80 homolog
DEG_SPOP_SBC_1
381:385
PRSSS
SPOP
0.9941
More...
Q8NE31
Protein FAM13C
DEG_SPOP_SBC_1
269:273
PRSSS
SPOP
0.9952
More...
Q8NEM0
Microcephalin
DEG_SPOP_SBC_1
349:353
PRSSS
SPOP
0.9918
More...
Q8TDI7
Transmembrane channel-like protein 2
DEG_SPOP_SBC_1
133:137
PRSSS
SPOP
0.9412
More...
Q8WXI9
Transcriptional repressor p66-beta
DEG_SPOP_SBC_1
136:140
PRSSS
SPOP
0.9922
More...
Q92794
Histone acetyltransferase KAT6A
DEG_SPOP_SBC_1
997:1001
PRSSS
SPOP
0.8724
More...
Q9H2D6
TRIO and F-actin-binding protein
DEG_SPOP_SBC_1
824:828
PRSSS
SPOP
0.9957
More...
Q9H992
E3 ubiquitin-protein ligase MARCHF7
DEG_SPOP_SBC_1
125:129
PRSSS
SPOP
0.8611
More...
Q9HCK8
Chromodomain-helicase-DNA-binding protein 8
DEG_SPOP_SBC_1
2216:2220
PRSSS
SPOP
0.9419
More...
Q9NYF8
Bcl-2-associated transcription factor 1
DEG_SPOP_SBC_1
139:143
PRSSS
SPOP
0.9945
More...
Q9P218
Collagen alpha-1
DEG_SPOP_SBC_1
1019:1023
PRSSS
SPOP
0.8033
More...
Q9UK33
Zinc finger protein 580
DEG_SPOP_SBC_1
11:15
PRSSS
SPOP
0.9779
More...
Q9UQB8
Brain-specific angiogenesis inhibitor 1-associated protein 2
DEG_SPOP_SBC_1
362:366
PRSSS
SPOP
0.9997
More...
Q9UQD0
Sodium channel protein type 8 subunit alpha
DEG_SPOP_SBC_1
474:478
PRSSS
SPOP
0.9727
More...
Q9Y2K6
Ubiquitin carboxyl-terminal hydrolase 20
DEG_SPOP_SBC_1
369:373
PRSSS
SPOP
0.9939
More...
Q5JSZ5
Protein PRRC2B
DEG_SPOP_SBC_1
922:926
PRSSS
SPOP
0.8891
More...
Q9Y4E6
WD repeat-containing protein 7
DEG_SPOP_SBC_1
1150:1154
PRSSS
SPOP
0.6871
More...
Q17RH7
Putative protein TPRXL
DEG_SPOP_SBC_1
203:207
PRSSS
SPOP
0.7838
More...