DegronMD

Uniprot ID: Q9UK33

Source protein: Zinc finger protein 580

Source gene: ZNF580

Class: DEG_SPOP_SBC_1

Location: 11:15

E3 ligase: SPOP

DEGRON score: 0.9779

ASA_SCORE: 75.08

COIL: 0.8918

CONS_SCORE: 0.95

DSS_SCORE: 0.8203

HELIX: 0.0212

FCONS_SCORE: 0.9796

RIG_SCORE: 0.4537

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S13F	TCGA-XF-A9T5	BLCA	TCGA	PRSSS	DEG_SPOP_SBC_1	0.9093
p.S13F	DO51925	BLCA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.9093
p.S14F	TCGA-EE-A29D	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	0.7982
p.S14F	DO38123	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	0.7982
p.R12G	SIDM00693	Bladder Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	0.6457
p.R12G	ACH-000396	Bladder Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	0.6457
p.R12G	J82	urinary_tract	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.6457
p.P5L	TCGA-4Z-AA7Y	BLCA	TCGA	PRSSS	DEG_SPOP_SBC_1	0.6111
p.P5L	DO51867	BLCA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.6111
p.A18V	SIDM00845	Burkitt's Lymphoma	GDSC	PRSSS	DEG_SPOP_SBC_1	0.25
p.A18V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	0.25
p.A18V	ACH-000786	Lymphoma	CCLE	PRSSS	DEG_SPOP_SBC_1	0.25
p.A18V	ACH-000992	Head and Neck Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	0.25
p.P6L	DO218333	BRCA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1944
p.P6S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	0.1944
p.P6S	SIDM00223	Small Cell Lung Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	0.1944
p.P21Q	TCGA-G7-6790	KIRP	TCGA	PRSSS	DEG_SPOP_SBC_1	0.1667
p.P21Q	DO20888	KIRP	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1667
p.L4P	SIDM00537	Colorectal Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	0.1389
p.L4P	ACH-000982	Colon/Colorectal Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	0.1389
p.L4P	ACH-001345	Colon/Colorectal Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	0.1389
p.L4P	GP5d	large_intestine	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.1389
p.P24T	TCGA-EE-A182	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	0.0833
p.P24T	DO37814	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 24 of 24 entries

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Drug responses associated with ZNF580 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PRSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	268:272	PRSSS	SPOP	0.9882	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_SPOP_SBC_1	1049:1053	PRSSS	SPOP	0.9955	More...
P41182	B-cell lymphoma 6 protein	DEG_SPOP_SBC_1	458:462	PRSSS	SPOP	0.5537	More...
Q9NYF8	Bcl-2-associated transcription factor 1	DEG_SPOP_SBC_1	139:143	PRSSS	SPOP	0.9945	More...
Q9UQB8	Brain-specific angiogenesis inhibitor 1-associated protein 2	DEG_SPOP_SBC_1	362:366	PRSSS	SPOP	0.9997	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	2216:2220	PRSSS	SPOP	0.9419	More...
Q9P218	Collagen alpha-1	DEG_SPOP_SBC_1	1019:1023	PRSSS	SPOP	0.8033	More...
P49619	Diacylglycerol kinase gamma	DEG_SPOP_SBC_1	149:153	PRSSS	SPOP	0.5556	More...
Q9H992	E3 ubiquitin-protein ligase MARCHF7	DEG_SPOP_SBC_1	125:129	PRSSS	SPOP	0.8611	More...
O75592	E3 ubiquitin-protein ligase MYCBP2	DEG_SPOP_SBC_1	2840:2844	PRSSS	SPOP	0.9962	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	4128:4132	PRSSS	SPOP	0.709	More...
P98177	Forkhead box protein O4	DEG_SPOP_SBC_1	258:262	PRSSS	SPOP	0.9997	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	997:1001	PRSSS	SPOP	0.8724	More...
Q13478	Interleukin-18 receptor 1	DEG_SPOP_SBC_1	70:74	PRSSS	SPOP	0.7325	More...
P78386	Keratin, type II cuticular Hb5	DEG_SPOP_SBC_1	491:495	PRSSS	SPOP	0.8473	More...
Q8NEM0	Microcephalin	DEG_SPOP_SBC_1	349:353	PRSSS	SPOP	0.9918	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	588:592	PRSSS	SPOP	0.7566	More...
P55201	Peregrin	DEG_SPOP_SBC_1	995:999	PRSSS	SPOP	0.9038	More...
Q13515	Phakinin	DEG_SPOP_SBC_1	30:34	PRSSS	SPOP	0.9701	More...
O75081	Protein CBFA2T3	DEG_SPOP_SBC_1	455:459	PRSSS	SPOP	0.6229	More...
Q8NE31	Protein FAM13C	DEG_SPOP_SBC_1	269:273	PRSSS	SPOP	0.9952	More...
Q5JSZ5	Protein PRRC2B	DEG_SPOP_SBC_1	922:926	PRSSS	SPOP	0.8891	More...
O94964	Protein SOGA1	DEG_SPOP_SBC_1	1168:1172	PRSSS	SPOP	0.9994	More...
Q8N2C7	Protein unc-80 homolog	DEG_SPOP_SBC_1	381:385	PRSSS	SPOP	0.9941	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	203:207	PRSSS	SPOP	0.7838	More...

Showing 1 to 25 of 38 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRSSS

Degron related mutations and impact score

Drug responses associated with ZNF580 mutations

All proteins holding degron of PRSSS