DegronMD - Q9NYF8(BCLAF1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R131W	TCGA-05-4405	LUAD	TCGA	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.R130H	TCGA-06-0209	GBM	TCGA	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R130H	TCGA-B5-A0JY	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R130H	HCC2998	large intestine	COSMIC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R131Q	TCGA-14-1829	GBM	TCGA	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.R131Q	DO13821	GBM	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.R131Q	DO49137	PACA	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.R131Q	VM-CUB-1	urinary tract	COSMIC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.P70T	TCGA-22-4596	LUSC	TCGA	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.1111
p.P70T	DO27739	LUSC	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.1111
p.Q419H	TCGA-32-1970	GBM	TCGA	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.0556
p.S147L	TCGA-34-2600	LUSC	TCGA	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2222
p.S147L	DO27081	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2222
p.R69P	TCGA-39-5034	LUSC	TCGA	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.1389
p.R69P	DO26854	LUSC	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.1389
p.S148Y	TCGA-44-6144	LUAD	TCGA	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation blocking phosphorylation signal	0.6389
p.S397L	TCGA-49-AARE	LUAD	TCGA	DYR	CBL_MET	407:409	Mutation blocking phosphorylation signal	0.5
p.R131P	TCGA-51-4079	LUSC	TCGA	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.R131P	DO26437	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.G66R	TCGA-55-7995	LUAD	TCGA	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1111
p.G66R	TCGA-55-7995	LUAD	TCGA	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.2222
p.G66R	DO45323	LUAD	ICGC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1111
p.G66R	DO45323	LUAD	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.2222
p.Q410K	TCGA-56-7582	LUSC	TCGA	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.3056
p.G72W	TCGA-73-4668	LUAD	TCGA	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.0556
p.G72W	DO23961	LUAD	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.0556
p.Y150H	TCGA-77-A5G6	LUSC	TCGA	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation blocking phosphorylation signal	0.5833
p.Y150H	DO50097	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation blocking phosphorylation signal	0.5833
p.Y150H	ACH-001049	Lung Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation blocking phosphorylation signal	0.5833
p.Y150H	CPC-N	lung	COSMIC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation blocking phosphorylation signal	0.5833
p.E398D	TCGA-95-7039	LUAD	TCGA	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.0833
p.R51S	TCGA-A5-A0G2	UCEC	TCGA	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1944
p.R51S	TCGA-A5-A0G2	UCEC	TCGA	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.0833
p.R51S	DO41235	UCEC	ICGC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1944
p.R51S	DO41235	UCEC	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.0833
p.S151N	TCGA-A5-A1OF	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation blocking phosphorylation signal	0.5556
p.D836H	TCGA-AG-3883	READ	TCGA	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.0833
p.D60N	TCGA-AP-A056	UCEC	TCGA	DYR	CBL_MET	60:62	Mutation altering degron motif	0.6932
p.D60N	TCGA-B5-A3FA	UCEC	TCGA	DYR	CBL_MET	60:62	Mutation altering degron motif	0.6932
p.D60N	DO52402	UCEC	ICGC	DYR	CBL_MET	60:62	Mutation altering degron motif	0.6932
p.D60N	DO43971	UCEC	ICGC	DYR	CBL_MET	60:62	Mutation altering degron motif	0.6932
p.R134I	TCGA-AP-A1DV	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1944
p.R134I	DO43186	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1944
p.R51H	TCGA-AX-A1CE	UCEC	TCGA	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1944
p.R51H	TCGA-AX-A1CE	UCEC	TCGA	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.0833
p.R51H	DO42280	UCEC	ICGC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1944
p.R51H	DO42280	UCEC	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.0833
p.S141L	TCGA-BF-AAP7	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.8778
p.S141L	DO219472	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.8778
p.S141L	ACH-000488	Esophageal Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.8778
p.S141L	TE-11	oesophagus	COSMIC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.8778
p.S129A	TCGA-BS-A0TJ	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0556
p.S129A	DO42953	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0556
p.D836N	TCGA-CA-6717	COAD	TCGA	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.0833
p.D851N	TCGA-DF-A2KU	UCEC	TCGA	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation altering degron motif	0.6932
p.D851N	TCGA-EO-A3AV	UCEC	TCGA	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation altering degron motif	0.6932
p.A417T	TCGA-DF-A2KU	UCEC	TCGA	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.1111
p.A417T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.1111
p.S136C	TCGA-DI-A1BU	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation blocking phosphorylation signal	0.6944
p.R145C	TCGA-EE-A2MS	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2778
p.R145C	ACH-000011	Bladder Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2778
p.R145C	ACH-000026	Bladder Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2778
p.K152R	TCGA-EE-A3JI	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation substituting flanking lysine	0.1944
p.K152R	DO47268	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation substituting flanking lysine	0.1944
p.R51C	TCGA-ER-A2NC	SKCM	TCGA	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1944
p.R51C	TCGA-ER-A2NC	SKCM	TCGA	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.0833
p.R51C	DO47318	SKCM	ICGC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1944
p.R51C	DO47318	SKCM	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.0833
p.R51C	SK-GT-2	stomach	COSMIC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1944
p.R51C	SK-GT-2	stomach	COSMIC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.0833
p.D401A	TCGA-FI-A2D0	UCEC	TCGA	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.1667
p.M67I	TCGA-FW-A3R5	SKCM	TCGA	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.0833
p.M67I	TCGA-FW-A3R5	SKCM	TCGA	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.1944
p.R69L	TCGA-G3-A3CG	LIHC	TCGA	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.1389
p.R137M	TCGA-L9-A8F4	LUAD	TCGA	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2778
p.R137M	DO49876	LUAD	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2778
p.R59C	TCGA-VQ-A8P2	STAD	TCGA	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.3056
p.R59C	TCGA-VQ-A8P2	STAD	TCGA	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.3056
p.R59C	DO51761	STAD	ICGC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.3056
p.R59C	DO51761	STAD	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.3056
p.Y858N	TCGA-W3-AA1V	SKCM	TCGA	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation blocking phosphorylation signal	0.5833
p.R131L	TCGA-XK-AAIW	PRAD	TCGA	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.S144A	TCGA-XV-A9W5	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.3056
p.P149L	TCGA-YG-AA3O	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.P149L	DO51299	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.E852K	DO737	BLCA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.3056
p.E852K	ATN-1	haematopoietic and lymphoid tissue	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.3056
p.K419N	DO4092	BRCA	ICGC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.0556
p.T837N	DO222960	BTCA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.1111
p.T837N	DO224668	COCA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.1111
p.T837N	DO224616	COCA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.1111
p.T837N	DO229010	COCA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.1111
p.T837N	DO229013	COCA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.1111
p.T837N	DO229016	COCA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.1111
p.T837N	DO229003	COCA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.1111
p.T837N	DO229005	COCA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.1111
p.L398F	DO10518	COAD	ICGC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.0833
p.E855D	DO9634	COAD	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.2222
p.S135Y	DO227731	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation blocking phosphorylation signal	0.6667
p.G66A	DO224628	COCA	ICGC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1111
p.G66A	DO224628	COCA	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.2222
p.G66A	DO222718	COCA	ICGC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1111
p.G66A	DO222718	COCA	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.2222
p.G66A	DO229010	COCA	ICGC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1111
p.G66A	DO229010	COCA	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.2222
p.G66A	DO229013	COCA	ICGC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1111
p.G66A	DO229013	COCA	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.2222
p.G66A	DO229016	COCA	ICGC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1111
p.G66A	DO229016	COCA	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.2222
p.G66A	DO229003	COCA	ICGC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1111
p.G66A	DO229003	COCA	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.2222
p.G66A	DO229005	COCA	ICGC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1111
p.G66A	DO229005	COCA	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.2222
p.G66A	DO231470	THCA	ICGC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1111
p.G66A	DO231470	THCA	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.2222
p.E411K	DO222884	COCA	ICGC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.2778
p.R69Q	DO223057	ESCA	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.1389
p.S146T	DO233644	GACA	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.25
p.Q417H	DO13144	GBM	ICGC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.1111
p.R130C	DO231991	LICA	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0833
p.R67L	DO22845	LIHC	ICGC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.0833
p.R67L	DO22845	LIHC	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.1944
p.S146Y	DO24190	LUAD	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.25
p.M854V	DO23726	LUAD	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.25
p.E850K	DO23996	LUAD	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation altering degron motif	0.7022
p.E850K	ATN-1	haematopoietic and lymphoid tissue	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation altering degron motif	0.7022
p.R129W	DO24656	LUAD	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0556
p.R56H	DO52361	LUSC	ICGC	DYR	CBL_MET	56:58	Mutation altering degron motif	0.8244
p.Q408K	DO26976	LUSC	ICGC	DYR	CBL_MET	407:409	Mutation altering degron motif	0.6944
p.E411D	DO26504	LUSC	ICGC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.2778
p.K860N	DO27596	LUSC	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.0833
p.S148F	DO220851	MELA	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation blocking phosphorylation signal	0.6389
p.S412L	DO220857	MELA	ICGC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.25
p.D416N	DO220878	MELA	ICGC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.1389
p.G397K	DO220903	MELA	ICGC	DYR	CBL_MET	407:409	Mutation blocking phosphorylation signal	0.5
p.K150N	DO220911	MELA	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation blocking phosphorylation signal	0.5833
p.D405N	DO222753	MELA	ICGC	DYR	CBL_MET	407:409	Mutation blocking phosphorylation signal	0.7222
p.G418I	DO222731	MELA	ICGC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.0833
p.D844N	DO222898	MELA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.3056
p.D844N	DO37471	SKCM	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.3056
p.S146F	DO229137	NKTL	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.25
p.R59H	DO228138	PBCA	ICGC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.3056
p.R59H	DO228138	PBCA	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.3056
p.E402D	DO232224	PBCA	ICGC	DYR	CBL_MET	407:409	Mutation blocking phosphorylation signal	0.6389
p.R129L	DO51407	PRAD	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0556
p.R143C	DO37567	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.8301
p.H404Y	DO37406	SKCM	ICGC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.25
p.H404Y	DO51268	SKCM	ICGC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.25
p.M65I	DO37406	SKCM	ICGC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1389
p.M65I	DO37406	SKCM	ICGC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.25
p.E855V	DO51276	SKCM	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.2222
p.F416V	DO51234	SKCM	ICGC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.1389
p.W836R	DO51234	SKCM	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.0833
p.S142A	DO219491	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.87
p.H838Y	DO38823	STAD	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.1389
p.H404R	DO231262	THCA	ICGC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.25
p.S134C	DO42023	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1944
p.A415T	DO223286	UCEC	ICGC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.1667
p.A415T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.1667
p.D849Y	DO41572	UCEC	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation altering degron motif	0.7325
p.S149N	DO42568	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.D399A	DO43891	UCEC	ICGC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.1111
p.K419T	DO41133	UCEC	ICGC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.0556
p.E411G	DO41488	UCEC	ICGC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.2778
p.P149T	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.P149T	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1667
p.R62K	SIDM00845	Burkitt's Lymphoma	GDSC	DYR	CBL_MET	60:62	Mutation altering degron motif	0.7237
p.M52I	SIDM00845	Burkitt's Lymphoma	GDSC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.2222
p.M52I	SIDM00845	Burkitt's Lymphoma	GDSC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.1111
p.M52I	Daudi	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.2222
p.M52I	Daudi	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.1111
p.G72E	SIDM00217	Colorectal Carcinoma	GDSC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.0556
p.G72E	ACH-000999	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.0556
p.G72E	SNU-1040	large intestine	COSMIC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.0556
p.S129Y	ACH-000371	Lymphoma	CCLE	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0556
p.S129Y	RL	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0556
p.G72R	ACH-000809	Esophageal Cancer	CCLE	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.0556
p.G72R	KYSE-410	oesophagus	COSMIC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.0556
p.S143Y	ACH-001355	Neuroblastoma	CCLE	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.712
p.S143Y	LAN-6	autonomic ganglia	COSMIC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.712
p.K861I	ACH-002235	Bladder Cancer	CCLE	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation substituting flanking lysine	0.1667
p.K861I	DSH1	urinary tract	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation substituting flanking lysine	0.1667
p.K861I	YH-13	central nervous system	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation substituting flanking lysine	0.1667
p.S141Y	LAN-6	autonomic ganglia	COSMIC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.8231
p.H418N	LXF-289	lung	COSMIC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.0833
p.E852D	Daudi	haematopoietic and lymphoid tissue	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.3056
p.R49C	SK-GT-2	stomach	COSMIC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1389
p.D849V	NCI-H740	lung	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation altering degron motif	0.7785
p.Y148H	CPC-N	lung	COSMIC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation blocking phosphorylation signal	0.6389
p.D839E	HOP-92	lung	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation blocking phosphorylation signal	0.6111
p.L397M	NCI-H1568	lung	COSMIC	DYR	CBL_MET	407:409	Mutation blocking phosphorylation signal	0.5
p.G70R	KYSE-410	oesophagus	COSMIC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.1111
p.G397E	SK-CO-1	large intestine	COSMIC	DYR	CBL_MET	407:409	Mutation blocking phosphorylation signal	0.5
p.G397E	OCI-LY-19	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	407:409	Mutation blocking phosphorylation signal	0.5
p.R413Q	SW48	large intestine	COSMIC	DYR	CBL_MET	407:409	Mutation blocking ubiquitination signal	0.6667
p.G399E	SK-CO-1	large intestine	COSMIC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.1111
p.G399E	OCI-LY-19	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	407:409	Mutation rewiring degron network	0.1111
p.G70E	SNU-1040	large intestine	COSMIC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.1111
p.R129Q	VM-CUB-1	urinary tract	COSMIC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0556
p.E850D	Daudi	haematopoietic and lymphoid tissue	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation altering degron motif	0.6758
p.D841E	HOP-92	lung	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.2222
p.S139L	TE-11	oesophagus	COSMIC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.7667
p.K859I	DSH1	urinary tract	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.1111
p.K859I	YH-13	central nervous system	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation rewiring degron network	0.1111
p.P147T	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.2222
p.D851V	NCI-H740	lung	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	845:851	Mutation altering degron motif	0.7785
p.M50I	Daudi	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	56:58	Mutation rewiring degron network	0.1667
p.M50I	Daudi	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	60:62	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BCLAF1

UniProt ID: Q9NYF8

Entrez ID: 9774

Protein name: Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BCLAF1 in