DegronMD

Uniprot ID: Q9NYF8

Source protein: Bcl-2-associated transcription factor 1

Source gene: BCLAF1

Class: LIG_APCC_ABBAyCdc20_2

Location: 845:851

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.912

ASA_SCORE: 69.8429

COIL: 0.54

CONS_SCORE: 0.6918

DSS_SCORE: 0.421

HELIX: 0.1406

FCONS_SCORE: 0.9838

RIG_SCORE: 0.7801

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D836H	TCGA-AG-3883	READ	TCGA	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D836N	TCGA-CA-6717	COAD	TCGA	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D851N	TCGA-DF-A2KU	UCEC	TCGA	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D851N	TCGA-EO-A3AV	UCEC	TCGA	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.6932
p.Y858N	TCGA-W3-AA1V	SKCM	TCGA	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.5833
p.E852K	DO737	BLCA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E852K	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.T837N	DO222960	BTCA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T837N	DO224668	COCA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T837N	DO224616	COCA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T837N	DO229010	COCA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T837N	DO229013	COCA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T837N	DO229016	COCA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T837N	DO229003	COCA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T837N	DO229005	COCA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E855D	DO9634	COAD	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.2222
p.M854V	DO23726	LUAD	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.25
p.E850K	DO23996	LUAD	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.7022
p.E850K	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.7022
p.K860N	DO27596	LUSC	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D844N	DO222898	MELA	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D844N	DO37471	SKCM	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E855V	DO51276	SKCM	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.2222
p.W836R	DO51234	SKCM	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.0833
p.H838Y	DO38823	STAD	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.1389
p.D849Y	DO41572	UCEC	ICGC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.7325
p.K861I	ACH-002235	Bladder Cancer	CCLE	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.K861I	DSH1	urinary_tract	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.K861I	YH-13	central_nervous_system	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.E852D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D849V	NCI-H740	lung	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.7785
p.D839E	HOP-92	lung	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.6111
p.E850D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.6758
p.D841E	HOP-92	lung	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.2222
p.K859I	DSH1	urinary_tract	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.K859I	YH-13	central_nervous_system	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.D851V	NCI-H740	lung	COSMIC	KYFLHDD	LIG_APCC_ABBAyCdc20_2	0.7785

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KYFLHDD

Degron related mutations and impact score

Drug responses associated with BCLAF1 mutations

All proteins holding degron of KYFLHDD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYF8	Bcl-2-associated transcription factor 1	LIG_APCC_ABBAyCdc20_2	845:851	KYFLHDD	APC,CDC20,FZR1	0.912	More...