DegronMD

Uniprot ID: Q9NYF8

Source protein: Bcl-2-associated transcription factor 1

Source gene: BCLAF1

Class: DEG_SPOP_SBC_1

Location: 139:143

E3 ligase: SPOP

DEGRON score: 0.9945

ASA_SCORE: 105.74

COIL: 0.9634

CONS_SCORE: 0.8591

DSS_SCORE: 0.7313

HELIX: 0.025

FCONS_SCORE: 1.0568

RIG_SCORE: 0.4319

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R131W	TCGA-05-4405	LUAD	TCGA	PRSSS	DEG_SPOP_SBC_1	0.1111
p.R130H	TCGA-06-0209	GBM	TCGA	PRSSS	DEG_SPOP_SBC_1	0.0833
p.R130H	TCGA-B5-A0JY	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	0.0833
p.R130H	HCC2998	large_intestine	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.0833
p.R131Q	TCGA-14-1829	GBM	TCGA	PRSSS	DEG_SPOP_SBC_1	0.1111
p.R131Q	DO13821	GBM	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1111
p.R131Q	DO49137	PACA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1111
p.R131Q	VM-CUB-1	urinary_tract	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.1111
p.S147L	TCGA-34-2600	LUSC	TCGA	PRSSS	DEG_SPOP_SBC_1	0.2222
p.S147L	DO27081	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	0.2222
p.S148Y	TCGA-44-6144	LUAD	TCGA	PRSSS	DEG_SPOP_SBC_1	0.6389
p.R131P	TCGA-51-4079	LUSC	TCGA	PRSSS	DEG_SPOP_SBC_1	0.1111
p.R131P	DO26437	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1111
p.Y150H	TCGA-77-A5G6	LUSC	TCGA	PRSSS	DEG_SPOP_SBC_1	0.5833
p.Y150H	DO50097	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	0.5833
p.Y150H	ACH-001049	Lung Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	0.5833
p.Y150H	CPC-N	lung	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.5833
p.S151N	TCGA-A5-A1OF	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	0.5556
p.R134I	TCGA-AP-A1DV	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	0.1944
p.R134I	DO43186	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1944
p.S141L	TCGA-BF-AAP7	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	0.8778
p.S141L	DO219472	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	0.8778
p.S141L	ACH-000488	Esophageal Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	0.8778
p.S141L	TE-11	oesophagus	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.8778
p.S129A	TCGA-BS-A0TJ	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	0.0556
p.S129A	DO42953	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	0.0556
p.S136C	TCGA-DI-A1BU	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	0.6944
p.R145C	TCGA-EE-A2MS	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	0.2778
p.R145C	ACH-000011	Bladder Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	0.2778
p.R145C	ACH-000026	Bladder Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	0.2778
p.K152R	TCGA-EE-A3JI	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	0.1944
p.K152R	DO47268	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1944
p.R137M	TCGA-L9-A8F4	LUAD	TCGA	PRSSS	DEG_SPOP_SBC_1	0.2778
p.R137M	DO49876	LUAD	ICGC	PRSSS	DEG_SPOP_SBC_1	0.2778
p.R131L	TCGA-XK-AAIW	PRAD	TCGA	PRSSS	DEG_SPOP_SBC_1	0.1111
p.S144A	TCGA-XV-A9W5	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	0.3056
p.P149L	TCGA-YG-AA3O	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	0.1667
p.P149L	DO51299	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1667
p.S135Y	DO227731	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.6667
p.S146T	DO233644	GACA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.25
p.R130C	DO231991	LICA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.0833
p.S146Y	DO24190	LUAD	ICGC	PRSSS	DEG_SPOP_SBC_1	0.25
p.R129W	DO24656	LUAD	ICGC	PRSSS	DEG_SPOP_SBC_1	0.0556
p.S148F	DO220851	MELA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.6389
p.K150N	DO220911	MELA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.5833
p.S146F	DO229137	NKTL	ICGC	PRSSS	DEG_SPOP_SBC_1	0.25
p.R129L	DO51407	PRAD	ICGC	PRSSS	DEG_SPOP_SBC_1	0.0556
p.R143C	DO37567	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	0.8301
p.S142A	DO219491	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	0.87
p.S134C	DO42023	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1944
p.S149N	DO42568	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1667
p.P149T	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	0.1667
p.P149T	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.1667
p.S129Y	ACH-000371	Lymphoma	CCLE	PRSSS	DEG_SPOP_SBC_1	0.0556
p.S129Y	RL	haematopoietic_and_lymphoid_tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.0556
p.S143Y	ACH-001355	Neuroblastoma	CCLE	PRSSS	DEG_SPOP_SBC_1	0.712
p.S143Y	LAN-6	autonomic_ganglia	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.712
p.S141Y	LAN-6	autonomic_ganglia	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.8231
p.Y148H	CPC-N	lung	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.6389
p.R129Q	VM-CUB-1	urinary_tract	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.0556
p.S139L	TE-11	oesophagus	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.7667
p.P147T	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7KAX9	Rho GTPase-activating protein 32	DEG_SPOP_SBC_1	728:732	PRSSS	SPOP	0.9943	More...
O75069	Transmembrane and coiled-coil domains protein 2	DEG_SPOP_SBC_1	218:222	PRSSS	SPOP	0.6944	More...
O75081	Protein CBFA2T3	DEG_SPOP_SBC_1	455:459	PRSSS	SPOP	0.6229	More...
O75592	E3 ubiquitin-protein ligase MYCBP2	DEG_SPOP_SBC_1	2840:2844	PRSSS	SPOP	0.9962	More...
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	154:158	PRSSS	SPOP	0.9256	More...
O94964	Protein SOGA1	DEG_SPOP_SBC_1	1168:1172	PRSSS	SPOP	0.9994	More...
P41182	B-cell lymphoma 6 protein	DEG_SPOP_SBC_1	458:462	PRSSS	SPOP	0.5537	More...
P49619	Diacylglycerol kinase gamma	DEG_SPOP_SBC_1	149:153	PRSSS	SPOP	0.5556	More...
P55201	Peregrin	DEG_SPOP_SBC_1	995:999	PRSSS	SPOP	0.9038	More...
P78386	Keratin, type II cuticular Hb5	DEG_SPOP_SBC_1	491:495	PRSSS	SPOP	0.8473	More...
P98177	Forkhead box protein O4	DEG_SPOP_SBC_1	258:262	PRSSS	SPOP	0.9997	More...
Q13478	Interleukin-18 receptor 1	DEG_SPOP_SBC_1	70:74	PRSSS	SPOP	0.7325	More...
Q13515	Phakinin	DEG_SPOP_SBC_1	30:34	PRSSS	SPOP	0.9701	More...
Q15431	Synaptonemal complex protein 1	DEG_SPOP_SBC_1	13:17	PRSSS	SPOP	0.9396	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	4128:4132	PRSSS	SPOP	0.709	More...
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	268:272	PRSSS	SPOP	0.9882	More...
Q6GYQ0	Ral GTPase-activating protein subunit alpha-1	DEG_SPOP_SBC_1	793:797	PRSSS	SPOP	0.9994	More...
Q6IQ55	Tau-tubulin kinase 2	DEG_SPOP_SBC_1	1155:1159	PRSSS	SPOP	0.8733	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	588:592	PRSSS	SPOP	0.7566	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_SPOP_SBC_1	1049:1053	PRSSS	SPOP	0.9955	More...
Q8N2C7	Protein unc-80 homolog	DEG_SPOP_SBC_1	381:385	PRSSS	SPOP	0.9941	More...
Q8NE31	Protein FAM13C	DEG_SPOP_SBC_1	269:273	PRSSS	SPOP	0.9952	More...
Q8NEM0	Microcephalin	DEG_SPOP_SBC_1	349:353	PRSSS	SPOP	0.9918	More...
Q8TDI7	Transmembrane channel-like protein 2	DEG_SPOP_SBC_1	133:137	PRSSS	SPOP	0.9412	More...
Q8WXI9	Transcriptional repressor p66-beta	DEG_SPOP_SBC_1	136:140	PRSSS	SPOP	0.9922	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	997:1001	PRSSS	SPOP	0.8724	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	824:828	PRSSS	SPOP	0.9957	More...
Q9H992	E3 ubiquitin-protein ligase MARCHF7	DEG_SPOP_SBC_1	125:129	PRSSS	SPOP	0.8611	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	2216:2220	PRSSS	SPOP	0.9419	More...
Q9NYF8	Bcl-2-associated transcription factor 1	DEG_SPOP_SBC_1	139:143	PRSSS	SPOP	0.9945	More...
Q9P218	Collagen alpha-1	DEG_SPOP_SBC_1	1019:1023	PRSSS	SPOP	0.8033	More...
Q9UK33	Zinc finger protein 580	DEG_SPOP_SBC_1	11:15	PRSSS	SPOP	0.9779	More...
Q9UQB8	Brain-specific angiogenesis inhibitor 1-associated protein 2	DEG_SPOP_SBC_1	362:366	PRSSS	SPOP	0.9997	More...
Q9UQD0	Sodium channel protein type 8 subunit alpha	DEG_SPOP_SBC_1	474:478	PRSSS	SPOP	0.9727	More...
Q9Y2K6	Ubiquitin carboxyl-terminal hydrolase 20	DEG_SPOP_SBC_1	369:373	PRSSS	SPOP	0.9939	More...
Q5JSZ5	Protein PRRC2B	DEG_SPOP_SBC_1	922:926	PRSSS	SPOP	0.8891	More...
Q9Y4E6	WD repeat-containing protein 7	DEG_SPOP_SBC_1	1150:1154	PRSSS	SPOP	0.6871	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	203:207	PRSSS	SPOP	0.7838	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRSSS

Degron related mutations and impact score

Drug responses associated with BCLAF1 mutations

All proteins holding degron of PRSSS