DegronMD - Q9P218(COL20A1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D145Y	TCGA-44-7670	LUAD	TCGA	PEPTPSHT	DEG_SCF_FBW7_1	134:141	Mutation rewiring degron network	0.2222
p.D145Y	DO23555	LUAD	ICGC	PEPTPSHT	DEG_SCF_FBW7_1	134:141	Mutation rewiring degron network	0.2222
p.A608T	TCGA-AA-3510	COAD	TCGA	PLSSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.1389
p.A608T	DO7783	COAD	ICGC	PLSSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.1389
p.V624A	TCGA-AP-A1DV	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.1944
p.V624A	DO43186	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.1944
p.R625C	TCGA-B5-A3FA	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.1667
p.R625C	DO52402	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.1667
p.P128T	TCGA-CD-8536	STAD	TCGA	PEPTPSHT	DEG_SCF_FBW7_1	134:141	Mutation rewiring degron network	0.1667
p.P128T	DO47827	STAD	ICGC	PEPTPSHT	DEG_SCF_FBW7_1	134:141	Mutation rewiring degron network	0.1667
p.T620S	TCGA-EA-A5ZE	CESC	TCGA	PLSSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.3056
p.T620S	DO49010	CESC	ICGC	PLSSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.3056
p.G142R	TCGA-EE-A2MS	SKCM	TCGA	PEPTPSHT	DEG_SCF_FBW7_1	134:141	Mutation rewiring degron network	0.3056
p.G142R	DO37567	SKCM	ICGC	PEPTPSHT	DEG_SCF_FBW7_1	134:141	Mutation rewiring degron network	0.3056
p.A1025V	TCGA-EO-A22R	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.2778
p.A1025V	DO42713	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.2778
p.A1025V	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.2778
p.A1025V	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.2778
p.S1023L	TCGA-JY-A938	ESCA	TCGA	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation altering degron motif	0.7667
p.S1023L	DO36556	READ	ICGC	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation altering degron motif	0.7667
p.S1023L	SIDM01955	Colorectal Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation altering degron motif	0.7667
p.A149V	TCGA-LT-A8JT	BLCA	TCGA	PEPTPSHT	DEG_SCF_FBW7_1	134:141	Mutation rewiring degron network	0.1111
p.A149V	DO51901	BLCA	ICGC	PEPTPSHT	DEG_SCF_FBW7_1	134:141	Mutation rewiring degron network	0.1111
p.T1009M	TCGA-NJ-A4YG	LUAD	TCGA	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.0556
p.T1009M	DO218941	LUAD	ICGC	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.0556
p.T1009M	SIDM02017	Colorectal Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.0556
p.S125R	TCGA-QC-A7B5	SARC	TCGA	PEPTPSHT	DEG_SCF_FBW7_1	134:141	Mutation rewiring degron network	0.0833
p.S125R	DO220239	SARC	ICGC	PEPTPSHT	DEG_SCF_FBW7_1	134:141	Mutation rewiring degron network	0.0833
p.G606E	TCGA-W3-AA1W	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.0833
p.G606E	DO51277	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.0833
p.P134L	DO234285	ESAD	ICGC	PEPTPSHT	DEG_SCF_FBW7_1	134:141	Mutation altering degron motif	0.6471
p.S124I	DO228985	LICA	ICGC	PEPTPSHT	DEG_SCF_FBW7_1	134:141	Mutation rewiring degron network	0.0556
p.C628F	DO229025	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.0833
p.S139Y	DO231830	LINC	ICGC	PEPTPSHT	DEG_SCF_FBW7_1	134:141	Mutation altering degron motif	0.6009
p.G1011E	DO222683	MELA	ICGC	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.1111
p.G614R	DO232445	PBCA	ICGC	PLSSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.3056
p.T1009A	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.0556
p.T1009A	ACH-000914	Lymphoma	CCLE	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.0556
p.T1009A	HT	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.0556
p.T623N	SIDM00761	Small Cell Lung Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.2222
p.T623N	NCI-H196	lung	COSMIC	PLSSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.2222
p.M1030I	SIDM00980	Gastric Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.1389
p.M1030I	23132-87	stomach	COSMIC	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.1389
p.G1018V	SIDM01387	Small Cell Lung Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.3056
p.G1018V	ACH-000921	Lung Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.3056
p.G1013S	ACH-000961	Endometrial/Uterine Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.1667
p.T1016A	HT	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.25
p.A1032V	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	1019:1023	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL20A1

UniProt ID: Q9P218

Entrez ID: 57642

Protein name: Collagen alpha-1(XX) chain

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL20A1 in