DegronMD

Uniprot ID: Q9P218

Source protein: Collagen alpha-1

Source gene: COL20A1

Class: DEG_SCF_FBW7_1

Location: 134:141

E3 ligase: FBXW7

DEGRON score: 0.9897

ASA_SCORE: 72.6125

COIL: 0.8543

CONS_SCORE: 0.4949

DSS_SCORE: 0.904

HELIX: 0.0343

FCONS_SCORE: 1.1587

RIG_SCORE: 0.4479

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D145Y	TCGA-44-7670	LUAD	TCGA	PEPTPSHT	DEG_SCF_FBW7_1	0.2222
p.D145Y	DO23555	LUAD	ICGC	PEPTPSHT	DEG_SCF_FBW7_1	0.2222
p.P128T	TCGA-CD-8536	STAD	TCGA	PEPTPSHT	DEG_SCF_FBW7_1	0.1667
p.P128T	DO47827	STAD	ICGC	PEPTPSHT	DEG_SCF_FBW7_1	0.1667
p.G142R	TCGA-EE-A2MS	SKCM	TCGA	PEPTPSHT	DEG_SCF_FBW7_1	0.3056
p.G142R	DO37567	SKCM	ICGC	PEPTPSHT	DEG_SCF_FBW7_1	0.3056
p.A149V	TCGA-LT-A8JT	BLCA	TCGA	PEPTPSHT	DEG_SCF_FBW7_1	0.1111
p.A149V	DO51901	BLCA	ICGC	PEPTPSHT	DEG_SCF_FBW7_1	0.1111
p.S125R	TCGA-QC-A7B5	SARC	TCGA	PEPTPSHT	DEG_SCF_FBW7_1	0.0833
p.S125R	DO220239	SARC	ICGC	PEPTPSHT	DEG_SCF_FBW7_1	0.0833
p.P134L	DO234285	ESAD	ICGC	PEPTPSHT	DEG_SCF_FBW7_1	0.6471
p.S124I	DO228985	LICA	ICGC	PEPTPSHT	DEG_SCF_FBW7_1	0.0556
p.S139Y	DO231830	LINC	ICGC	PEPTPSHT	DEG_SCF_FBW7_1	0.6009

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P218	Collagen alpha-1	DEG_SCF_FBW7_1	134:141	PEPTPSHT	FBXW7	0.9897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons