DegronMD - Q8NEM0(MCPH1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S174T	TCGA-55-8620	LUAD	TCGA	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.1389
p.S174T	DO24547	LUAD	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.1389
p.T163I	TCGA-A5-A0G2	UCEC	TCGA	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation altering degron motif	0.7078
p.T163I	DO41235	UCEC	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation altering degron motif	0.7078
p.P646Q	TCGA-A8-A097	BRCA	TCGA	IKPHEE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.0556
p.P646Q	DO6240	BRCA	ICGC	IKPHEE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.0556
p.P646S	TCGA-A8-A09Z	BRCA	TCGA	IKPHEE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.0556
p.P646S	DO5521	BRCA	ICGC	IKPHEE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.0556
p.T594M	TCGA-AA-3864	COAD	TCGA	EKENL	DEG_APCC_KENBOX_2	598:602	Mutation rewiring degron network	0.2222
p.T594M	SIDM01112	Osteosarcoma	GDSC	EKENL	DEG_APCC_KENBOX_2	598:602	Mutation rewiring degron network	0.2222
p.R358I	TCGA-AA-3977	COAD	TCGA	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1944
p.N169H	TCGA-AA-3984	COAD	TCGA	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.2778
p.N169H	DO9002	COAD	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.2778
p.L630V	TCGA-AH-6644	READ	TCGA	IKPHEE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.3056
p.L630V	DO37237	READ	ICGC	IKPHEE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.3056
p.L637F	TCGA-CF-A1HS	BLCA	TCGA	IKPHEE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.3056
p.L637F	TCGA-D7-6525	STAD	TCGA	IKPHEE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.3056
p.L637F	DO486	BLCA	ICGC	IKPHEE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.3056
p.L637F	DO38783	STAD	ICGC	IKPHEE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.3056
p.F154I	TCGA-D1-A16X	UCEC	TCGA	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.1667
p.F154I	DO41799	UCEC	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.1667
p.L343I	TCGA-FI-A2D5	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1667
p.S352F	TCGA-GF-A6C9	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation altering degron motif	0.7982
p.R350M	TCGA-IB-7651	PAAD	TCGA	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation altering degron motif	0.7521
p.D625E	TCGA-KK-A6E3	PRAD	TCGA	IKPHEE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.1667
p.D625E	DO51357	PRAD	ICGC	IKPHEE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.1667
p.L166F	DO225307	BRCA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation altering degron motif	0.6981
p.A350V	DO229378	BTCA	ICGC	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation altering degron motif	0.6936
p.R170H	DO49095	COAD	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.25
p.R170H	DO51761	STAD	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.25
p.R171S	DO229010	COCA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.2222
p.R171S	DO229013	COCA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.2222
p.R171S	DO229016	COCA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.2222
p.R171S	DO229003	COCA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.2222
p.R171S	DO229005	COCA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.2222
p.D344G	DO229010	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1944
p.D344G	DO229013	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1944
p.D344G	DO229016	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1944
p.D344G	DO229003	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1944
p.D344G	DO229005	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1944
p.N612S	DO222478	ESCA	ICGC	EKENL	DEG_APCC_KENBOX_2	598:602	Mutation rewiring degron network	0.0556
p.T165A	DO233930	GACA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation altering degron motif	0.6028
p.D176G	DO44443	HNSC	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.0833
p.I168T	DO229480	LAML	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.3056
p.M176I	DO229038	LICA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.0833
p.C359F	DO45069	LINC	ICGC	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1667
p.D171N	DO230961	LUSC	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.2222
p.D171N	DO224594	LUSC	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.2222
p.N156H	DO26434	LUSC	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.2222
p.Q151R	DO223719	LUSC	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.0833
p.Q151R	DO47981	STAD	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.0833
p.Q151R	ROS-50	haematopoietic and lymphoid tissue	COSMIC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.0833
p.G351R	DO223723	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation altering degron motif	0.7568
p.P165L	DO222363	MELA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation altering degron motif	0.7582
p.P165S	DO222875	MELA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation altering degron motif	0.6752
p.Y162N	DO233292	NACA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation altering degron motif	0.5948
p.P150L	DO46396	OV	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.0556
p.D176A	DO35242	PACA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.0833
p.P157Q	DO37631	SKCM	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.25
p.L357F	DO47268	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation substituting flanking lysine	0.3333
p.R341W	DO50301	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1111
p.D176Y	DO37921	SKCM	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.0833
p.H154N	DO47636	SKCM	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.1667
p.S174R	DO229240	THCA	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.1389
p.L357I	DO42568	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation substituting flanking lysine	0.3333
p.I168S	DO41235	UCEC	ICGC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.3056
p.G626S	SIDM00860	Head and Neck Carcinoma	GDSC	IKPHEE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.1944
p.G626S	FADU	upper aerodigestive tract	COSMIC	IKPHEE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.1944
p.G641R	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	IKPHEE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.1944
p.G641R	ACH-002214	Lymphoma	CCLE	IKPHEE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.1944
p.G641R	BC-1	haematopoietic and lymphoid tissue	COSMIC	IKPHEE	LIG_APCC_ABBA_1	631:636	Mutation rewiring degron network	0.1944
p.K340E	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation substituting flanking lysine	0.1944
p.K340E	ACH-000233	Lymphoma	CCLE	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation substituting flanking lysine	0.1944
p.K340E	DEL	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation substituting flanking lysine	0.1944
p.L602F	SIDM01439	Hepatocellular Carcinoma	GDSC	EKENL	DEG_APCC_KENBOX_2	598:602	Mutation altering degron motif	0.587
p.H634R	ACH-001850	Gallbladder Cancer	CCLE	IKPHEE	LIG_APCC_ABBA_1	631:636	Mutation altering degron motif	0.8244
p.I168V	ACH-002014	Eye Cancer	CCLE	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.3056
p.I168V	ACH-002018	Eye Cancer	CCLE	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.3056
p.S342L	SK-UT-1	soft tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1389
p.L357P	KMS-11	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation substituting flanking lysine	0.3333
p.L357P	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation substituting flanking lysine	0.3333
p.T172A	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.1944
p.C340F	A427	lung	COSMIC	PRSSS	DEG_SPOP_SBC_1	349:353	Mutation substituting flanking lysine	0.1944
p.T172I	NCI-H1155	lung	COSMIC	LIYTPTIE	DEG_SCF_FBW7_2	160:167	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MCPH1

UniProt ID: Q8NEM0

Entrez ID: 79648

Protein name: Microcephalin

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MCPH1 in