DegronMD

Uniprot ID: Q8NEM0

Source protein: Microcephalin

Source gene: MCPH1

Class: LIG_APCC_ABBA_1

Location: 631:636

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8234

ASA_SCORE: 108.6167

COIL: 0.7035

CONS_SCORE: 0.3836

DSS_SCORE: 0.5217

HELIX: 0.249

FCONS_SCORE: 0.9584

RIG_SCORE: 0.7507

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P646Q	TCGA-A8-A097	BRCA	TCGA	IKPHEE	LIG_APCC_ABBA_1	0.0556
p.P646Q	DO6240	BRCA	ICGC	IKPHEE	LIG_APCC_ABBA_1	0.0556
p.P646S	TCGA-A8-A09Z	BRCA	TCGA	IKPHEE	LIG_APCC_ABBA_1	0.0556
p.P646S	DO5521	BRCA	ICGC	IKPHEE	LIG_APCC_ABBA_1	0.0556
p.L630V	TCGA-AH-6644	READ	TCGA	IKPHEE	LIG_APCC_ABBA_1	0.3056
p.L630V	DO37237	READ	ICGC	IKPHEE	LIG_APCC_ABBA_1	0.3056
p.L637F	TCGA-CF-A1HS	BLCA	TCGA	IKPHEE	LIG_APCC_ABBA_1	0.3056
p.L637F	TCGA-D7-6525	STAD	TCGA	IKPHEE	LIG_APCC_ABBA_1	0.3056
p.L637F	DO486	BLCA	ICGC	IKPHEE	LIG_APCC_ABBA_1	0.3056
p.L637F	DO38783	STAD	ICGC	IKPHEE	LIG_APCC_ABBA_1	0.3056
p.D625E	TCGA-KK-A6E3	PRAD	TCGA	IKPHEE	LIG_APCC_ABBA_1	0.1667
p.D625E	DO51357	PRAD	ICGC	IKPHEE	LIG_APCC_ABBA_1	0.1667
p.G626S	SIDM00860	Head and Neck Carcinoma	GDSC	IKPHEE	LIG_APCC_ABBA_1	0.1944
p.G626S	FADU	upper_aerodigestive_tract	COSMIC	IKPHEE	LIG_APCC_ABBA_1	0.1944
p.G641R	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	IKPHEE	LIG_APCC_ABBA_1	0.1944
p.G641R	ACH-002214	Lymphoma	CCLE	IKPHEE	LIG_APCC_ABBA_1	0.1944
p.G641R	BC-1	haematopoietic_and_lymphoid_tissue	COSMIC	IKPHEE	LIG_APCC_ABBA_1	0.1944
p.H634R	ACH-001850	Gallbladder Cancer	CCLE	IKPHEE	LIG_APCC_ABBA_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEM0	Microcephalin	LIG_APCC_ABBA_1	631:636	IKPHEE	APC,CDC20,FZR1	0.8234	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons