DegronMD

Uniprot ID: Q8NEM0

Source protein: Microcephalin

Source gene: MCPH1

Class: DEG_APCC_KENBOX_2

Location: 598:602

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.971

ASA_SCORE: 98.58

COIL: 0.6866

CONS_SCORE: 0.3968

DSS_SCORE: 0.598

HELIX: 0.299

FCONS_SCORE: 1.0037

RIG_SCORE: 0.7005

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T594M	TCGA-AA-3864	COAD	TCGA	EKENL	DEG_APCC_KENBOX_2	0.2222
p.T594M	SIDM01112	Osteosarcoma	GDSC	EKENL	DEG_APCC_KENBOX_2	0.2222
p.N612S	DO222478	ESCA	ICGC	EKENL	DEG_APCC_KENBOX_2	0.0556
p.L602F	SIDM01439	Hepatocellular Carcinoma	GDSC	EKENL	DEG_APCC_KENBOX_2	0.587

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	DEG_APCC_KENBOX_2	4:8	EKENL	APC,CDC20,FZR1	0.7413	More...
P52179	Myomesin-1	DEG_APCC_KENBOX_2	128:132	EKENL	APC,CDC20,FZR1	0.9051	More...
Q3V6T2	Girdin	DEG_APCC_KENBOX_2	381:385	EKENL	APC,CDC20,FZR1	0.5571	More...
Q5VZM2	Ras-related GTP-binding protein B	DEG_APCC_KENBOX_2	11:15	EKENL	APC,CDC20,FZR1	0.8752	More...
Q71F23	Centromere protein U	DEG_APCC_KENBOX_2	196:200	EKENL	APC,CDC20,FZR1	0.9329	More...
Q8NEM0	Microcephalin	DEG_APCC_KENBOX_2	598:602	EKENL	APC,CDC20,FZR1	0.971	More...
Q9H0I2	Enkurin domain-containing protein 1	DEG_APCC_KENBOX_2	101:105	EKENL	APC,CDC20,FZR1	0.9868	More...
Q9UBT2	SUMO-activating enzyme subunit 2	DEG_APCC_KENBOX_2	616:620	EKENL	APC,CDC20,FZR1	0.9466	More...
Q9ULW0	Targeting protein for Xklp2	DEG_APCC_KENBOX_2	86:90	EKENL	APC,CDC20,FZR1	0.9952	More...
A6NNH2	Protein FAM90A27P	DEG_APCC_KENBOX_2	77:81	EKENL	APC,CDC20,FZR1	0.9811	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons