DegronMD

Uniprot ID: A0AVK6

Source protein: Transcription factor E2F8

Source gene: E2F8

Class: DEG_APCC_KENBOX_2

Location: 4:8

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7413

ASA_SCORE: 94.12

COIL: 0.6744

CONS_SCORE: 0.3187

DSS_SCORE: 0.7353

HELIX: 0.2322

FCONS_SCORE: 1.1156

RIG_SCORE: 0.7511

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K5E	TCGA-17-Z031	LUAD	TCGA	EKENL	DEG_APCC_KENBOX_2	0.7022
p.M18T	TCGA-85-7697	LUSC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.0556
p.M18T	DO27053	LUSC	ICGC	EKENL	DEG_APCC_KENBOX_2	0.0556
p.M18I	TCGA-AX-A2HD	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.0556
p.M18I	TCGA-XF-A9T0	BLCA	TCGA	EKENL	DEG_APCC_KENBOX_2	0.0556
p.M18I	DO51920	BLCA	ICGC	EKENL	DEG_APCC_KENBOX_2	0.0556
p.M18I	DO42608	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	0.0556
p.L8I	TCGA-B5-A0JY	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.6063
p.L8I	TCGA-EY-A1GI	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	0.6063
p.L8I	DO43041	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	0.6063
p.L8I	DO41211	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	0.6063
p.E6K	TCGA-BT-A2LB	BLCA	TCGA	EKENL	DEG_APCC_KENBOX_2	0.7022
p.E6K	DO44098	BLCA	ICGC	EKENL	DEG_APCC_KENBOX_2	0.7022
p.G16E	DO227976	COCA	ICGC	EKENL	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	DEG_APCC_KENBOX_2	4:8	EKENL	APC,CDC20,FZR1	0.7413	More...
P52179	Myomesin-1	DEG_APCC_KENBOX_2	128:132	EKENL	APC,CDC20,FZR1	0.9051	More...
Q3V6T2	Girdin	DEG_APCC_KENBOX_2	381:385	EKENL	APC,CDC20,FZR1	0.5571	More...
Q5VZM2	Ras-related GTP-binding protein B	DEG_APCC_KENBOX_2	11:15	EKENL	APC,CDC20,FZR1	0.8752	More...
Q71F23	Centromere protein U	DEG_APCC_KENBOX_2	196:200	EKENL	APC,CDC20,FZR1	0.9329	More...
Q8NEM0	Microcephalin	DEG_APCC_KENBOX_2	598:602	EKENL	APC,CDC20,FZR1	0.971	More...
Q9H0I2	Enkurin domain-containing protein 1	DEG_APCC_KENBOX_2	101:105	EKENL	APC,CDC20,FZR1	0.9868	More...
Q9UBT2	SUMO-activating enzyme subunit 2	DEG_APCC_KENBOX_2	616:620	EKENL	APC,CDC20,FZR1	0.9466	More...
Q9ULW0	Targeting protein for Xklp2	DEG_APCC_KENBOX_2	86:90	EKENL	APC,CDC20,FZR1	0.9952	More...
A6NNH2	Protein FAM90A27P	DEG_APCC_KENBOX_2	77:81	EKENL	APC,CDC20,FZR1	0.9811	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons