DegronMD - A0AVK6(E2F8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K5E	TCGA-17-Z031	LUAD	TCGA	EKENL	DEG_APCC_KENBOX_2	4:8	Mutation altering degron motif	0.7022
p.K5E	TCGA-17-Z031	LUAD	TCGA	KENLFCE	LIG_APCC_ABBAyCdc20_2	5:11	Mutation altering degron motif	0.7022
p.Q817K	TCGA-37-4130	LUSC	TCGA	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.3056
p.Q817K	DO26490	LUSC	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.3056
p.M18T	TCGA-85-7697	LUSC	TCGA	EKENL	DEG_APCC_KENBOX_2	4:8	Mutation rewiring degron network	0.0556
p.M18T	TCGA-85-7697	LUSC	TCGA	KENLFCE	LIG_APCC_ABBAyCdc20_2	5:11	Mutation rewiring degron network	0.1389
p.M18T	DO27053	LUSC	ICGC	EKENL	DEG_APCC_KENBOX_2	4:8	Mutation rewiring degron network	0.0556
p.M18T	DO27053	LUSC	ICGC	KENLFCE	LIG_APCC_ABBAyCdc20_2	5:11	Mutation rewiring degron network	0.1389
p.N381H	TCGA-A6-3808	COAD	TCGA	SKENC	DEG_APCC_KENBOX_2	374:378	Mutation rewiring degron network	0.25
p.N381H	DO8408	COAD	ICGC	SKENC	DEG_APCC_KENBOX_2	374:378	Mutation rewiring degron network	0.25
p.S835R	TCGA-A6-6780	COAD	TCGA	PTSSS	DEG_SPOP_SBC_1	833:837	Mutation altering degron motif	0.7427
p.S835R	DO10244	COAD	ICGC	PTSSS	DEG_SPOP_SBC_1	833:837	Mutation altering degron motif	0.7427
p.R372L	TCGA-A8-A09Z	BRCA	TCGA	SKENC	DEG_APCC_KENBOX_2	374:378	Mutation rewiring degron network	0.2778
p.R372L	DO5521	BRCA	ICGC	SKENC	DEG_APCC_KENBOX_2	374:378	Mutation rewiring degron network	0.2778
p.R372L	DO233261	GACA	ICGC	SKENC	DEG_APCC_KENBOX_2	374:378	Mutation rewiring degron network	0.2778
p.R825C	TCGA-AA-3821	COAD	TCGA	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.0833
p.R825C	TCGA-AA-3821	COAD	TCGA	PTSSS	DEG_SPOP_SBC_1	833:837	Mutation rewiring degron network	0.1111
p.R825C	TCGA-D1-A1NY	UCEC	TCGA	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.0833
p.R825C	TCGA-D1-A1NY	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	833:837	Mutation rewiring degron network	0.1111
p.R825C	DO9314	COAD	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.0833
p.R825C	DO9314	COAD	ICGC	PTSSS	DEG_SPOP_SBC_1	833:837	Mutation rewiring degron network	0.1111
p.R825C	DO229467	SKCA	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.0833
p.R825C	DO229467	SKCA	ICGC	PTSSS	DEG_SPOP_SBC_1	833:837	Mutation rewiring degron network	0.1111
p.R825C	DO42512	UCEC	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.0833
p.R825C	DO42512	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	833:837	Mutation rewiring degron network	0.1111
p.C838Y	TCGA-AB-2826	LAML	TCGA	PTSSS	DEG_SPOP_SBC_1	833:837	Mutation rewiring degron network	0.3056
p.C838Y	DO21833	LAML	ICGC	PTSSS	DEG_SPOP_SBC_1	833:837	Mutation rewiring degron network	0.3056
p.P808H	TCGA-AP-A051	UCEC	TCGA	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.3056
p.P808H	DO42673	UCEC	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.3056
p.S683A	TCGA-AP-A051	UCEC	TCGA	PVTSS	DEG_SPOP_SBC_1	679:683	Mutation altering degron motif	0.7588
p.S683A	DO42673	UCEC	ICGC	PVTSS	DEG_SPOP_SBC_1	679:683	Mutation altering degron motif	0.7588
p.V677G	TCGA-AP-A059	UCEC	TCGA	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation altering degron motif	0.7532
p.V677G	DO41361	UCEC	ICGC	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation altering degron motif	0.7532
p.R386C	TCGA-AX-A1CE	UCEC	TCGA	SKENC	DEG_APCC_KENBOX_2	374:378	Mutation rewiring degron network	0.1111
p.R386C	DO42280	UCEC	ICGC	SKENC	DEG_APCC_KENBOX_2	374:378	Mutation rewiring degron network	0.1111
p.R386C	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	SKENC	DEG_APCC_KENBOX_2	374:378	Mutation rewiring degron network	0.1111
p.M18I	TCGA-AX-A2HD	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	4:8	Mutation rewiring degron network	0.0556
p.M18I	TCGA-AX-A2HD	UCEC	TCGA	KENLFCE	LIG_APCC_ABBAyCdc20_2	5:11	Mutation rewiring degron network	0.1389
p.M18I	TCGA-XF-A9T0	BLCA	TCGA	EKENL	DEG_APCC_KENBOX_2	4:8	Mutation rewiring degron network	0.0556
p.M18I	TCGA-XF-A9T0	BLCA	TCGA	KENLFCE	LIG_APCC_ABBAyCdc20_2	5:11	Mutation rewiring degron network	0.1389
p.M18I	DO51920	BLCA	ICGC	EKENL	DEG_APCC_KENBOX_2	4:8	Mutation rewiring degron network	0.0556
p.M18I	DO51920	BLCA	ICGC	KENLFCE	LIG_APCC_ABBAyCdc20_2	5:11	Mutation rewiring degron network	0.1389
p.M18I	DO42608	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	4:8	Mutation rewiring degron network	0.0556
p.M18I	DO42608	UCEC	ICGC	KENLFCE	LIG_APCC_ABBAyCdc20_2	5:11	Mutation rewiring degron network	0.1389
p.L8I	TCGA-B5-A0JY	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	4:8	Mutation altering degron motif	0.6063
p.L8I	TCGA-B5-A0JY	UCEC	TCGA	KENLFCE	LIG_APCC_ABBAyCdc20_2	5:11	Mutation altering degron motif	0.6063
p.L8I	TCGA-EY-A1GI	UCEC	TCGA	EKENL	DEG_APCC_KENBOX_2	4:8	Mutation altering degron motif	0.6063
p.L8I	TCGA-EY-A1GI	UCEC	TCGA	KENLFCE	LIG_APCC_ABBAyCdc20_2	5:11	Mutation altering degron motif	0.6063
p.L8I	DO43041	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	4:8	Mutation altering degron motif	0.6063
p.L8I	DO43041	UCEC	ICGC	KENLFCE	LIG_APCC_ABBAyCdc20_2	5:11	Mutation altering degron motif	0.6063
p.L8I	DO41211	UCEC	ICGC	EKENL	DEG_APCC_KENBOX_2	4:8	Mutation altering degron motif	0.6063
p.L8I	DO41211	UCEC	ICGC	KENLFCE	LIG_APCC_ABBAyCdc20_2	5:11	Mutation altering degron motif	0.6063
p.A662V	TCGA-BK-A6W3	UCEC	TCGA	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation rewiring degron network	0.0556
p.A662V	DO50076	UCEC	ICGC	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation rewiring degron network	0.0556
p.E6K	TCGA-BT-A2LB	BLCA	TCGA	EKENL	DEG_APCC_KENBOX_2	4:8	Mutation altering degron motif	0.7022
p.E6K	TCGA-BT-A2LB	BLCA	TCGA	KENLFCE	LIG_APCC_ABBAyCdc20_2	5:11	Mutation altering degron motif	0.591
p.E6K	DO44098	BLCA	ICGC	EKENL	DEG_APCC_KENBOX_2	4:8	Mutation altering degron motif	0.7022
p.E6K	DO44098	BLCA	ICGC	KENLFCE	LIG_APCC_ABBAyCdc20_2	5:11	Mutation altering degron motif	0.591
p.R668K	TCGA-D3-A8GC	SKCM	TCGA	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation rewiring degron network	0.2222
p.R668K	TCGA-EE-A181	SKCM	TCGA	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation rewiring degron network	0.2222
p.R668K	TCGA-RP-A695	SKCM	TCGA	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation rewiring degron network	0.2222
p.R668K	DO37444	SKCM	ICGC	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation rewiring degron network	0.2222
p.R668K	DO50281	SKCM	ICGC	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation rewiring degron network	0.2222
p.R668K	DO51270	SKCM	ICGC	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation rewiring degron network	0.2222
p.K814N	TCGA-D8-A1XK	BRCA	TCGA	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation altering degron motif	0.5806
p.K814N	DO4749	BRCA	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation altering degron motif	0.5806
p.G387W	TCGA-D9-A1JX	SKCM	TCGA	SKENC	DEG_APCC_KENBOX_2	374:378	Mutation rewiring degron network	0.0833
p.G387W	DO37711	SKCM	ICGC	SKENC	DEG_APCC_KENBOX_2	374:378	Mutation rewiring degron network	0.0833
p.S682L	TCGA-DA-A1I7	SKCM	TCGA	PVTSS	DEG_SPOP_SBC_1	679:683	Mutation altering degron motif	0.7667
p.S682L	DO37951	SKCM	ICGC	PVTSS	DEG_SPOP_SBC_1	679:683	Mutation altering degron motif	0.7667
p.A687V	TCGA-DF-A2KU	UCEC	TCGA	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation rewiring degron network	0.1389
p.A687V	TCGA-DF-A2KU	UCEC	TCGA	PVTSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.2222
p.A687V	DO223286	UCEC	ICGC	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation rewiring degron network	0.1389
p.A687V	DO223286	UCEC	ICGC	PVTSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.2222
p.A687V	SIDM01608	Endometrial Carcinoma	GDSC	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation rewiring degron network	0.1389
p.A687V	SIDM01608	Endometrial Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.2222
p.A687V	ACH-000990	Endometrial/Uterine Cancer	CCLE	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation rewiring degron network	0.1389
p.A687V	ACH-000990	Endometrial/Uterine Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.2222
p.T834I	TCGA-DU-6392	LGG	TCGA	PTSSS	DEG_SPOP_SBC_1	833:837	Mutation altering degron motif	0.5966
p.T834I	DO22237	LGG	ICGC	PTSSS	DEG_SPOP_SBC_1	833:837	Mutation altering degron motif	0.5966
p.P691S	TCGA-EE-A3JD	SKCM	TCGA	PVTSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.1111
p.P691S	TCGA-ER-A19M	SKCM	TCGA	PVTSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.1111
p.P691S	DO37798	SKCM	ICGC	PVTSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.1111
p.P691S	DO50299	SKCM	ICGC	PVTSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.1111
p.F9V	TCGA-EO-A22U	UCEC	TCGA	KENLFCE	LIG_APCC_ABBAyCdc20_2	5:11	Mutation altering degron motif	0.7068
p.F9V	DO43755	UCEC	ICGC	KENLFCE	LIG_APCC_ABBAyCdc20_2	5:11	Mutation altering degron motif	0.7068
p.P679T	TCGA-EO-A3B0	UCEC	TCGA	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation altering degron motif	0.7031
p.P679T	TCGA-EO-A3B0	UCEC	TCGA	PVTSS	DEG_SPOP_SBC_1	679:683	Mutation altering degron motif	0.7031
p.P679T	DO219773	UCEC	ICGC	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation altering degron motif	0.7031
p.P679T	DO219773	UCEC	ICGC	PVTSS	DEG_SPOP_SBC_1	679:683	Mutation altering degron motif	0.7031
p.P808S	TCGA-FI-A2D0	UCEC	TCGA	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.3056
p.P808S	DO43891	UCEC	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.3056
p.S384F	TCGA-FS-A4F0	SKCM	TCGA	SKENC	DEG_APCC_KENBOX_2	374:378	Mutation rewiring degron network	0.1667
p.S384F	DO37891	SKCM	ICGC	SKENC	DEG_APCC_KENBOX_2	374:378	Mutation rewiring degron network	0.1667
p.G804W	TCGA-WR-A838	OV	TCGA	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.1944
p.G804W	DO50088	OV	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.1944
p.P691H	DO225370	BRCA	ICGC	PVTSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.1111
p.T847A	DO227709	COCA	ICGC	PTSSS	DEG_SPOP_SBC_1	833:837	Mutation rewiring degron network	0.0556
p.G16E	DO227976	COCA	ICGC	EKENL	DEG_APCC_KENBOX_2	4:8	Mutation rewiring degron network	0.1111
p.G16E	DO227976	COCA	ICGC	KENLFCE	LIG_APCC_ABBAyCdc20_2	5:11	Mutation rewiring degron network	0.1944
p.Q807H	DO227979	COCA	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.2778
p.T385A	DO222492	COCA	ICGC	SKENC	DEG_APCC_KENBOX_2	374:378	Mutation rewiring degron network	0.1389
p.P679Q	DO229015	LICA	ICGC	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation altering degron motif	0.7035
p.P679Q	DO229015	LICA	ICGC	PVTSS	DEG_SPOP_SBC_1	679:683	Mutation altering degron motif	0.7035
p.A662D	DO229028	LICA	ICGC	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation rewiring degron network	0.0556
p.A805E	DO229038	LICA	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.2222
p.N666K	DO229006	LICA	ICGC	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation rewiring degron network	0.1667
p.K380N	DO50904	LICA	ICGC	SKENC	DEG_APCC_KENBOX_2	374:378	Mutation rewiring degron network	0.2778
p.P810L	DO220911	MELA	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation altering degron motif	0.6471
p.T803I	DO229229	THCA	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.1667
p.I674V	SIDM01265	Plasma Cell Myeloma	GDSC	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation altering degron motif	0.5965
p.I674V	SIDM00529	Breast Carcinoma	GDSC	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation altering degron motif	0.5965
p.I674V	SIDM00673	Breast Carcinoma	GDSC	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation altering degron motif	0.5965
p.I674V	SIDM00760	Small Cell Lung Carcinoma	GDSC	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation altering degron motif	0.5965
p.I674V	SIDM00785	Acute Myeloid Leukemia	GDSC	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation altering degron motif	0.5965
p.P21L	SIDM00596	Endometrial Carcinoma	GDSC	KENLFCE	LIG_APCC_ABBAyCdc20_2	5:11	Mutation rewiring degron network	0.0556
p.P21L	ACH-001517	Endometrial/Uterine Cancer	CCLE	KENLFCE	LIG_APCC_ABBAyCdc20_2	5:11	Mutation rewiring degron network	0.0556
p.P21L	HEC-1	endometrium	COSMIC	KENLFCE	LIG_APCC_ABBAyCdc20_2	5:11	Mutation rewiring degron network	0.0556
p.P673R	SIDM00261	Ewing's Sarcoma	GDSC	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation altering degron motif	0.7512
p.I678V	SIDM00500	Colorectal Carcinoma	GDSC	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation altering degron motif	0.5965
p.I678V	ACH-000959	Colon/Colorectal Cancer	CCLE	SPIAGVIPV	DEG_SIAH_1	672:680	Mutation altering degron motif	0.5965
p.A805T	ACH-000278	Ovarian Cancer	CCLE	VPVTPKGS	DEG_SCF_FBW7_1	809:816	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

E2F8

UniProt ID: A0AVK6

Entrez ID: 79733

Protein name: Transcription factor E2F8 (E2F-8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for E2F8 in