DegronMD

Uniprot ID: A0AVK6

Source protein: Transcription factor E2F8

Source gene: E2F8

Class: LIG_APCC_ABBAyCdc20_2

Location: 5:11

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9469

ASA_SCORE: 84.7143

COIL: 0.6887

CONS_SCORE: 0.3074

DSS_SCORE: 0.6345

HELIX: 0.22

FCONS_SCORE: 1.0659

RIG_SCORE: 0.7734

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K5E	TCGA-17-Z031	LUAD	TCGA	KENLFCE	LIG_APCC_ABBAyCdc20_2	0.7022
p.M18T	TCGA-85-7697	LUSC	TCGA	KENLFCE	LIG_APCC_ABBAyCdc20_2	0.1389
p.M18T	DO27053	LUSC	ICGC	KENLFCE	LIG_APCC_ABBAyCdc20_2	0.1389
p.M18I	TCGA-AX-A2HD	UCEC	TCGA	KENLFCE	LIG_APCC_ABBAyCdc20_2	0.1389
p.M18I	TCGA-XF-A9T0	BLCA	TCGA	KENLFCE	LIG_APCC_ABBAyCdc20_2	0.1389
p.M18I	DO51920	BLCA	ICGC	KENLFCE	LIG_APCC_ABBAyCdc20_2	0.1389
p.M18I	DO42608	UCEC	ICGC	KENLFCE	LIG_APCC_ABBAyCdc20_2	0.1389
p.L8I	TCGA-B5-A0JY	UCEC	TCGA	KENLFCE	LIG_APCC_ABBAyCdc20_2	0.6063
p.L8I	TCGA-EY-A1GI	UCEC	TCGA	KENLFCE	LIG_APCC_ABBAyCdc20_2	0.6063
p.L8I	DO43041	UCEC	ICGC	KENLFCE	LIG_APCC_ABBAyCdc20_2	0.6063
p.L8I	DO41211	UCEC	ICGC	KENLFCE	LIG_APCC_ABBAyCdc20_2	0.6063
p.E6K	TCGA-BT-A2LB	BLCA	TCGA	KENLFCE	LIG_APCC_ABBAyCdc20_2	0.591
p.E6K	DO44098	BLCA	ICGC	KENLFCE	LIG_APCC_ABBAyCdc20_2	0.591
p.F9V	TCGA-EO-A22U	UCEC	TCGA	KENLFCE	LIG_APCC_ABBAyCdc20_2	0.7068
p.F9V	DO43755	UCEC	ICGC	KENLFCE	LIG_APCC_ABBAyCdc20_2	0.7068
p.G16E	DO227976	COCA	ICGC	KENLFCE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P21L	SIDM00596	Endometrial Carcinoma	GDSC	KENLFCE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P21L	ACH-001517	Endometrial/Uterine Cancer	CCLE	KENLFCE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P21L	HEC-1	endometrium	COSMIC	KENLFCE	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	LIG_APCC_ABBAyCdc20_2	5:11	KENLFCE	APC,CDC20,FZR1	0.9469	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons