DegronMD

Uniprot ID: A0AVK6

Source protein: Transcription factor E2F8

Source gene: E2F8

Class: DEG_SIAH_1

Location: 672:680

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.5559

ASA_SCORE: 66.7667

COIL: 0.7698

CONS_SCORE: 0.3099

DSS_SCORE: 0.2039

HELIX: 0.0209

FCONS_SCORE: 1.0852

RIG_SCORE: 0.7317

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V677G	TCGA-AP-A059	UCEC	TCGA	SPIAGVIPV	DEG_SIAH_1	0.7532
p.V677G	DO41361	UCEC	ICGC	SPIAGVIPV	DEG_SIAH_1	0.7532
p.A662V	TCGA-BK-A6W3	UCEC	TCGA	SPIAGVIPV	DEG_SIAH_1	0.0556
p.A662V	DO50076	UCEC	ICGC	SPIAGVIPV	DEG_SIAH_1	0.0556
p.R668K	TCGA-D3-A8GC	SKCM	TCGA	SPIAGVIPV	DEG_SIAH_1	0.2222
p.R668K	TCGA-EE-A181	SKCM	TCGA	SPIAGVIPV	DEG_SIAH_1	0.2222
p.R668K	TCGA-RP-A695	SKCM	TCGA	SPIAGVIPV	DEG_SIAH_1	0.2222
p.R668K	DO37444	SKCM	ICGC	SPIAGVIPV	DEG_SIAH_1	0.2222
p.R668K	DO50281	SKCM	ICGC	SPIAGVIPV	DEG_SIAH_1	0.2222
p.R668K	DO51270	SKCM	ICGC	SPIAGVIPV	DEG_SIAH_1	0.2222
p.A687V	TCGA-DF-A2KU	UCEC	TCGA	SPIAGVIPV	DEG_SIAH_1	0.1389
p.A687V	DO223286	UCEC	ICGC	SPIAGVIPV	DEG_SIAH_1	0.1389
p.A687V	SIDM01608	Endometrial Carcinoma	GDSC	SPIAGVIPV	DEG_SIAH_1	0.1389
p.A687V	ACH-000990	Endometrial/Uterine Cancer	CCLE	SPIAGVIPV	DEG_SIAH_1	0.1389
p.P679T	TCGA-EO-A3B0	UCEC	TCGA	SPIAGVIPV	DEG_SIAH_1	0.7031
p.P679T	DO219773	UCEC	ICGC	SPIAGVIPV	DEG_SIAH_1	0.7031
p.P679Q	DO229015	LICA	ICGC	SPIAGVIPV	DEG_SIAH_1	0.7035
p.A662D	DO229028	LICA	ICGC	SPIAGVIPV	DEG_SIAH_1	0.0556
p.N666K	DO229006	LICA	ICGC	SPIAGVIPV	DEG_SIAH_1	0.1667
p.I674V	SIDM01265	Plasma Cell Myeloma	GDSC	SPIAGVIPV	DEG_SIAH_1	0.5965
p.I674V	SIDM00529	Breast Carcinoma	GDSC	SPIAGVIPV	DEG_SIAH_1	0.5965
p.I674V	SIDM00673	Breast Carcinoma	GDSC	SPIAGVIPV	DEG_SIAH_1	0.5965
p.I674V	SIDM00760	Small Cell Lung Carcinoma	GDSC	SPIAGVIPV	DEG_SIAH_1	0.5965
p.I674V	SIDM00785	Acute Myeloid Leukemia	GDSC	SPIAGVIPV	DEG_SIAH_1	0.5965
p.P673R	SIDM00261	Ewing's Sarcoma	GDSC	SPIAGVIPV	DEG_SIAH_1	0.7512
p.I678V	SIDM00500	Colorectal Carcinoma	GDSC	SPIAGVIPV	DEG_SIAH_1	0.5965
p.I678V	ACH-000959	Colon/Colorectal Cancer	CCLE	SPIAGVIPV	DEG_SIAH_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	DEG_SIAH_1	672:680	SPIAGVIPV	SIAH1,SIAH2,SIAH3	0.5559	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SPIAGVIPV

Degron related mutations and impact score

Drug responses associated with E2F8 mutations

All proteins holding degron of SPIAGVIPV