DegronMD

Uniprot ID: A0AVK6

Source protein: Transcription factor E2F8

Source gene: E2F8

Class: DEG_SCF_FBW7_1

Location: 809:816

E3 ligase: FBXW7

DEGRON score: 0.9823

ASA_SCORE: 79.95

COIL: 0.8914

CONS_SCORE: 0.3102

DSS_SCORE: 0.5469

HELIX: 0.0174

FCONS_SCORE: 1.0369

RIG_SCORE: 0.6903

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q817K	TCGA-37-4130	LUSC	TCGA	VPVTPKGS	DEG_SCF_FBW7_1	0.3056
p.Q817K	DO26490	LUSC	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	0.3056
p.R825C	TCGA-AA-3821	COAD	TCGA	VPVTPKGS	DEG_SCF_FBW7_1	0.0833
p.R825C	TCGA-D1-A1NY	UCEC	TCGA	VPVTPKGS	DEG_SCF_FBW7_1	0.0833
p.R825C	DO9314	COAD	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	0.0833
p.R825C	DO229467	SKCA	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	0.0833
p.R825C	DO42512	UCEC	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	0.0833
p.P808H	TCGA-AP-A051	UCEC	TCGA	VPVTPKGS	DEG_SCF_FBW7_1	0.3056
p.P808H	DO42673	UCEC	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	0.3056
p.K814N	TCGA-D8-A1XK	BRCA	TCGA	VPVTPKGS	DEG_SCF_FBW7_1	0.5806
p.K814N	DO4749	BRCA	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	0.5806
p.P808S	TCGA-FI-A2D0	UCEC	TCGA	VPVTPKGS	DEG_SCF_FBW7_1	0.3056
p.P808S	DO43891	UCEC	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	0.3056
p.G804W	TCGA-WR-A838	OV	TCGA	VPVTPKGS	DEG_SCF_FBW7_1	0.1944
p.G804W	DO50088	OV	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	0.1944
p.Q807H	DO227979	COCA	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	0.2778
p.A805E	DO229038	LICA	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	0.2222
p.P810L	DO220911	MELA	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	0.6471
p.T803I	DO229229	THCA	ICGC	VPVTPKGS	DEG_SCF_FBW7_1	0.1667
p.A805T	ACH-000278	Ovarian Cancer	CCLE	VPVTPKGS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	DEG_SCF_FBW7_1	809:816	VPVTPKGS	FBXW7	0.9823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons